ID S5Q800_9PRIM Unreviewed; 1040 AA.
AC S5Q800;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Toll-like receptor 8 {ECO:0000313|EMBL:AGR83543.1};
DE Flags: Fragment;
GN Name=TLR8 {ECO:0000313|EMBL:AGR83543.1};
OS Gorilla gorilla (western gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9593 {ECO:0000313|EMBL:AGR83543.1};
RN [1] {ECO:0000313|EMBL:AGR83543.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=A07 {ECO:0000313|EMBL:AGR83531.1}, B06
RC {ECO:0000313|EMBL:AGR83533.1}, B07 {ECO:0000313|EMBL:AGR83535.1}, C06
RC {ECO:0000313|EMBL:AGR83536.1}, C07 {ECO:0000313|EMBL:AGR83537.1}, D06
RC {ECO:0000313|EMBL:AGR83538.1}, D07 {ECO:0000313|EMBL:AGR83539.1}, E06
RC {ECO:0000313|EMBL:AGR83541.1}, E07 {ECO:0000313|EMBL:AGR83542.1}, F06
RC {ECO:0000313|EMBL:AGR83543.1}, F07 {ECO:0000313|EMBL:AGR83544.1}, G06
RC {ECO:0000313|EMBL:AGR83547.1}, G07 {ECO:0000313|EMBL:AGR83548.1}, H06
RC {ECO:0000313|EMBL:AGR83551.1}, and H07 {ECO:0000313|EMBL:AGR83552.1};
RX PubMed=23851028; DOI=10.1093/hmg/ddt335;
RA Quach H., Wilson D., Laval G., Patin E., Manry J., Guibert J.,
RA Barreiro L.B., Nerrienet E., Verschoor E., Gessain A., Przeworski M.,
RA Quintana-Murci L.;
RT "Different selective pressures shape the evolution of Toll-like receptors
RT in human and African great ape populations.";
RL Hum. Mol. Genet. 22:4829-4840(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; KF321257; AGR83531.1; -; Genomic_DNA.
DR EMBL; KF321258; AGR83532.1; -; Genomic_DNA.
DR EMBL; KF321259; AGR83533.1; -; Genomic_DNA.
DR EMBL; KF321260; AGR83534.1; -; Genomic_DNA.
DR EMBL; KF321261; AGR83535.1; -; Genomic_DNA.
DR EMBL; KF321262; AGR83536.1; -; Genomic_DNA.
DR EMBL; KF321263; AGR83537.1; -; Genomic_DNA.
DR EMBL; KF321264; AGR83538.1; -; Genomic_DNA.
DR EMBL; KF321265; AGR83539.1; -; Genomic_DNA.
DR EMBL; KF321267; AGR83541.1; -; Genomic_DNA.
DR EMBL; KF321268; AGR83542.1; -; Genomic_DNA.
DR EMBL; KF321269; AGR83543.1; -; Genomic_DNA.
DR EMBL; KF321270; AGR83544.1; -; Genomic_DNA.
DR EMBL; KF321271; AGR83545.1; -; Genomic_DNA.
DR EMBL; KF321273; AGR83547.1; -; Genomic_DNA.
DR EMBL; KF321274; AGR83548.1; -; Genomic_DNA.
DR EMBL; KF321275; AGR83549.1; -; Genomic_DNA.
DR EMBL; KF321277; AGR83551.1; -; Genomic_DNA.
DR EMBL; KF321278; AGR83552.1; -; Genomic_DNA.
DR AlphaFoldDB; S5Q800; -.
DR OMA; LSWNCYF; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0060255; P:regulation of macromolecule metabolic process; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR47410; TOLL-LIKE RECEPTOR 7-RELATED; 1.
DR PANTHER; PTHR47410:SF1; TOLL-LIKE RECEPTOR 8; 1.
DR Pfam; PF13855; LRR_8; 5.
DR Pfam; PF01582; TIR; 1.
DR SMART; SM00365; LRR_SD22; 9.
DR SMART; SM00369; LRR_TYP; 15.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 5.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:AGR83543.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..1040
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007727118"
FT TRANSMEM 825..847
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 877..1021
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AGR83543.1"
SQ SEQUENCE 1040 AA; 119612 MW; 61910D9A8A1F7930 CRC64;
ENMFLQSSML TCIFLLISGS CELCAEENFS RSYPCDEKKQ NDSVIAECSN RRLQEVPQTV
GKYVTELDLS DNFITHITNE SFQGLQNLTK INLNHNPNVQ HQNGNPGIQS NGLNITDGAF
LNLKNLRELL LEDNQLPQIP SGLPESLTEL SLIQNNIYNI TKEGISRLIN LKNLYLAWNC
YFNKVCEKTN VEDGVFETLT NLELLSLSFN SLSHVPPKLP SSLRKLFLSN TQIKYISEED
FKGLINLTLL DLSGNCPRCF NAPFPCVPCD GGASINIDRF AFQNLTQLRY LNLSSTSLRK
INAAWFKNMP HLKVLDLEFN YLVGEIASGA FLTMLPRLEI LDLSFNYIKG SYPQHINISK
NFSKLLSLRA LHLRGYVFQE LREDDFQPLM QLPNLSTINL GINFIKQIDF KLFQNFSNLE
IIYLSENRIS PLVKDTRQSY ANSSSFQRHI LKRRSTDFEF DPHSNFYHFT RPLIKPQCAA
YGKALDLSLN SIFFIGPNQF ENLPDIACLN LSANSNAQVL SGTEFSAIPH VKYLDLTNNR
LDFDNASALT ELSDLEVLDL SYNSHYFRIA GVTHHLEFIQ NFTNLKVLNL SHNNIYTLTD
KYNLESKSLV ELVFSGNRLD ILWNDDDNRY ISIFKGLKNL TRLDLSLNRL KHIPNEAFLN
LPASLTELHI NDNMLKFFNW TLLQQFPRLE LLDLRGNKLL FLTDSLSDFT SSLRTLLLSH
NRISHLPSGF LSEVSSLKHL DLSSNLLKTI NKSALETKTT TKLSMLELHG NPFECTCDIG
DFRRWMDEHL NVKIPRLVDV ICASPGDQRG KSIVSLELTT CVSDVTAVIL FFFTFFITTM
VMLAALAHHL FYWDVWFIYN VCLAKVKGYR SLSTSQTFYD AYISYDTKDA SVTDWVINEL
RYHLEESRDK NVLLCLEERD WDPGLAIIDN LMQSINQSKK TVFVLTKKYA KSWNFKTAFY
LALQRLMDEN MDVIIFILLE PVLQHSQYLR LRQRICKSSI LQWPDNPKAE GLFWQTLRNV
VLTENDSRYN NMYVDSIKQY
//
