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Database: UniProt
Entry: S5SY68_9PROT
LinkDB: S5SY68_9PROT
Original site: S5SY68_9PROT 
ID   S5SY68_9PROT            Unreviewed;       703 AA.
AC   S5SY68;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   24-JAN-2024, entry version 52.
DE   RecName: Full=leucine--tRNA ligase {ECO:0000256|ARBA:ARBA00013164};
DE            EC=6.1.1.4 {ECO:0000256|ARBA:ARBA00013164};
GN   Name=leuS {ECO:0000313|EMBL:AGS33235.1};
GN   ORFNames=NASALF_087 {ECO:0000313|EMBL:AGS33235.1};
OS   Candidatus Nasuia deltocephalinicola str. NAS-ALF.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Candidatus Nasuia.
OX   NCBI_TaxID=1343077 {ECO:0000313|EMBL:AGS33235.1, ECO:0000313|Proteomes:UP000015382};
RN   [1] {ECO:0000313|EMBL:AGS33235.1, ECO:0000313|Proteomes:UP000015382}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NAS-ALF {ECO:0000313|Proteomes:UP000015382};
RX   PubMed=23918810; DOI=10.1093/gbe/evt118;
RA   Bennett G.M., Moran N.A.;
RT   "Small, smaller, smallest: the origins and evolution of ancient dual
RT   symbioses in a Phloem-feeding insect.";
RL   Genome Biol. Evol. 5:1675-1688(2013).
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC       {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363035}.
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DR   EMBL; CP006059; AGS33235.1; -; Genomic_DNA.
DR   AlphaFoldDB; S5SY68; -.
DR   KEGG; ndl:NASALF_087; -.
DR   HOGENOM; CLU_432575_0_0_4; -.
DR   OrthoDB; 9810365at2; -.
DR   Proteomes; UP000015382; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004823; F:leucine-tRNA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006429; P:leucyl-tRNA aminoacylation; IEA:InterPro.
DR   Gene3D; 3.40.50.620; HUPs; 2.
DR   InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR   InterPro; IPR002300; aa-tRNA-synth_Ia.
DR   InterPro; IPR002302; Leu-tRNA-ligase.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   PANTHER; PTHR43740:SF2; LEUCINE--TRNA LIGASE, MITOCHONDRIAL-RELATED; 1.
DR   PANTHER; PTHR43740; LEUCYL-TRNA SYNTHETASE; 1.
DR   Pfam; PF00133; tRNA-synt_1; 1.
DR   PRINTS; PR00985; TRNASYNTHLEU.
DR   SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR   PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW   ECO:0000256|RuleBase:RU363035};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363035};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363035};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU363035};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW   ECO:0000256|RuleBase:RU363035};
KW   Reference proteome {ECO:0000313|Proteomes:UP000015382}.
FT   DOMAIN          13..509
FT                   /note="Aminoacyl-tRNA synthetase class Ia"
FT                   /evidence="ECO:0000259|Pfam:PF00133"
SQ   SEQUENCE   703 AA;  86531 MW;  D7D9CF87E248983C CRC64;
     MFFKTNNNIP MIPYPSGRIH IGHFRNYMIN DIYNRFLFLI NYKSKMLISW DAFGTPAENA
     SLKNNMFPIN YLKNNIFFMK KQLKSSYLSI LWQKEFKTSD VNYYLFNQML IFKLIKNNLL
     YISNKKINWD ECDKTVLSNE QVIKGLGWRS SCIVYKKNIL TYYFKINYAI NEIYKEIENL
     DWPDRVKIMQ KNWIFNINFY YYFYFNFFRK KMKKIFFLKN FFSFFHFFSK KLIFLNRINK
     LLNSGNFISN IYLNMKVEFW FFKKKKFYFL NYKNISLKYF YLKKLYINIR YKFKALTILE
     FLILFKIKKF IILKIKLKIK DWGISRQRYW GFPIPIYYCE KCKRFYNSFK HFPILISKNL
     KNNINYFKTL NNLIECEFCG SKSFKENSTG DTFIDSSWYF LKYFKKNYEY NLVFPIDLYV
     GGIEHAILHL LYSRYIFKIL RNLKYLNFGE PVKKLFSQGI ILNKVLKFKK SKIEKMSKSK
     NNIVTPDEIS KNYSIDSLRI SILKNPFKKN FIWREYVIKN SNSFFKNIFK KLNLILKEKF
     FKTYFFFYKY KIIYKFIINN LKNFLYLIKK IYYDRIIILL FKIFKIINFK KIFNVFIIKD
     IYFKILKNFF VFFPSIIIKF WKLLKFKNIL KINFKEFYFK ILLKNSYKLK KIIILINNKM
     IGIFALSKLK KKKIFNFIFF KKKIFKKNIY KIIFINNSIE IIA
//
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