ID S5VJ42_STRC3 Unreviewed; 644 AA.
AC S5VJ42;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Integral membrane protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=B446_18790 {ECO:0000313|EMBL:AGS70572.1};
OS Streptomyces collinus (strain DSM 40733 / Tue 365).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1214242 {ECO:0000313|EMBL:AGS70572.1, ECO:0000313|Proteomes:UP000015423};
RN [1] {ECO:0000313|Proteomes:UP000015423}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40733 / Tue 365 {ECO:0000313|Proteomes:UP000015423};
RA Ruckert C., Szczepanowski R., Goesmann A., Pross E.K., Musiol E.M.,
RA Blin K., Wohlleben W., Puhler A., Weber T., Kalinowski J.;
RT "The complete genome sequence of Streptomyces collinus Tu 365.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AGS70572.1, ECO:0000313|Proteomes:UP000015423}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40733 / Tue 365 {ECO:0000313|Proteomes:UP000015423};
RX PubMed=24140291; DOI=10.1016/j.jbiotec.2013.10.004;
RA Ruckert C., Szczepanowski R., Albersmeier A., Goesmann A., Iftime D.,
RA Musiol E.M., Blin K., Wohlleben W., Puhler A., Kalinowski J., Weber T.;
RT "Complete genome sequence of the kirromycin producer Streptomyces collinus
RT Tu 365 consisting of a linear chromosome and two linear plasmids.";
RL J. Biotechnol. 168:739-740(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP006259; AGS70572.1; -; Genomic_DNA.
DR RefSeq; WP_020941034.1; NC_021985.1.
DR AlphaFoldDB; S5VJ42; -.
DR STRING; 1214242.B446_18790; -.
DR KEGG; sci:B446_18790; -.
DR PATRIC; fig|1214242.5.peg.3851; -.
DR eggNOG; COG1276; Bacteria.
DR eggNOG; COG2372; Bacteria.
DR HOGENOM; CLU_023176_0_0_11; -.
DR Proteomes; UP000015423; Chromosome.
DR GO; GO:0042597; C:periplasmic space; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR GO; GO:0006825; P:copper ion transport; IEA:InterPro.
DR GO; GO:0046688; P:response to copper ion; IEA:InterPro.
DR Gene3D; 2.60.40.1220; -; 1.
DR InterPro; IPR032694; CopC/D.
DR InterPro; IPR007348; CopC_dom.
DR InterPro; IPR008457; Cu-R_CopD_dom.
DR InterPro; IPR014755; Cu-Rt/internalin_Ig-like.
DR InterPro; IPR014756; Ig_E-set.
DR PANTHER; PTHR34820; INNER MEMBRANE PROTEIN YEBZ; 1.
DR PANTHER; PTHR34820:SF4; INNER MEMBRANE PROTEIN YEBZ; 1.
DR Pfam; PF04234; CopC; 1.
DR Pfam; PF05425; CopD; 1.
DR SUPFAM; SSF81296; E set domains; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Copper {ECO:0000256|ARBA:ARBA00023008};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000015423};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..34
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 35..644
FT /note="Integral membrane protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004541970"
FT TRANSMEM 156..176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 188..206
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 237..258
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 270..289
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 309..330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 342..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 380..400
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 483..501
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 33..127
FT /note="CopC"
FT /evidence="ECO:0000259|Pfam:PF04234"
FT DOMAIN 341..421
FT /note="Copper resistance protein D"
FT /evidence="ECO:0000259|Pfam:PF05425"
FT REGION 419..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 507..545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 507..532
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 644 AA; 66856 MW; C6266958F39CBB87 CRC64;
MTRTIAPRLR TLVLLLLTVT GALLAGAAPA SAHAALTGSD PAQGVVVDKA PTQVSLTFSE
KVAMNDDSLQ VLDPKGKDVA VGAPVNPGGT TYAVKLKGNL PKGTYTVAYQ VVSEDSHPVS
GAYTFSIGAP SQTVVSGVGT AAGGGVVGGL YAAGRYVSYA GFIVLAGGAA FVLACWQRGS
GVRAVQRLVV GGWLALTAAT LWLLLLRGSY TSSGKFGDVF DLNLLGQVLQ TKTGAALVSR
LLLLAAAALF IAVLFGAYNR REEPAEKRDL TFGLAVGGVV VAAGLAASWA MAEHASTGLQ
PGIAMPVDVL HLLAVAAWLG GLAALLVALY RAPAETPVGS AAVHRFSRVA FGSVVVLVAT
GTYQSWRQLG SWSAFTETRY GQLLLVKIAL VALLVGIAWI SRRWTGRLLE TAGARTAEKA
QREKEREKEQ VGSAAGKPSG RKTASGADAR AAQLARQRAA VDAARQKRLR DADPNRFGLR
RSVLAEAGVA VVLLAVTTWL TQTEPGRTEL DAKASTSSTS PSSSSSPADS SGALTLDMPF
DTGGTDGKGL VRIDLDPARV GGNEMHVYVQ RPNGRAFDVP EVKVAFTLEA KKLGPLPVTP
DHITTGHWSA SGVQIPMAGD WKIAVTVRTS DIDQVTVSKN AQIG
//
