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Database: UniProt
Entry: S5VJA1_STRC3
LinkDB: S5VJA1_STRC3
Original site: S5VJA1_STRC3 
ID   S5VJA1_STRC3            Unreviewed;       665 AA.
AC   S5VJA1;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   05-JUL-2017, entry version 34.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:AGS70647.1};
GN   ORFNames=B446_19165 {ECO:0000313|EMBL:AGS70647.1};
OS   Streptomyces collinus (strain DSM 40733 / Tu 365).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1214242 {ECO:0000313|EMBL:AGS70647.1, ECO:0000313|Proteomes:UP000015423};
RN   [1] {ECO:0000313|Proteomes:UP000015423}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 40733 / Tu 365 {ECO:0000313|Proteomes:UP000015423};
RA   Ruckert C., Szczepanowski R., Goesmann A., Pross E.K., Musiol E.M.,
RA   Blin K., Wohlleben W., Puhler A., Weber T., Kalinowski J.;
RT   "The complete genome sequence of Streptomyces collinus Tu 365.";
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP006259; AGS70647.1; -; Genomic_DNA.
DR   EnsemblBacteria; AGS70647; AGS70647; B446_19165.
DR   KEGG; sci:B446_19165; -.
DR   PATRIC; fig|1214242.5.peg.3924; -.
DR   KO; K02313; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000015423; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000015423};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000015423}.
FT   DOMAIN      358    486       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      572    641       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     366    373       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   665 AA;  74006 MW;  7F20299856B1A7B3 CRC64;
     MWPRVLDQLL GEGRGQGVEA KDEHWIRRCQ PLALVADTAL LAVPNEFAKN VLEGRLAPVV
     SETLSRECGR PIRIAITVDD SAGEPPAPQP SPGQPQRYEE PEPPSAYEGY GRHRAPEPPP
     GGEPGPRGEQ MPTARPAYPS EYQRPEPGAW PRSGQDDYGW QQQRLGFPER DPYASPSQES
     YGSSGQDSYG APSQDYRPQS VDRPSYEPKR GDYDAPHPDY DRPERSDYRR QDRSDYDRQE
     RPDYDRPDRS DYDRPDRSDY SVPRAEYDQR DPVRRELPDA PGGAGPAHRG GPGRPDLPPA
     GGSGAPGPLA AKPAPASGPG EPTARLNPKY LFDTFVIGAS NRFAHAAAVA VAEAPAKAYN
     PLFIYGESGL GKTHLLHAIG HYARSLYPGT RVRYVSSEEF TNEFINSIRD GKGDSFRKRY
     REMDILLVDD IQFLADKEST QEEFFHTFNT LHNANKQIVL SSDRPPKQLV TLEDRLRNRF
     EWGLITDVQP PELETRIAIL RKKAVQEQLN APPEVLEFIA SRISRNIREL EGALIRVTAF
     ASLNRQPVDL GLTEIVLKDL IPGGEDSAPE ITATAIMGAT ADYFGLTVED LCGTSRGRAL
     VTARQIAMYL CRELTDLSLP KIGAQFGGRD HTTVMHADRK IRALMAERRS IYNQVTELTN
     RIKNG
//
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