ID S5ZKF8_HBV Unreviewed; 820 AA.
AC S5ZKF8;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE RecName: Full=Protein P {ECO:0000256|ARBA:ARBA00021149};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:AGT38651.1};
OS Hepatitis B virus (HBV).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX NCBI_TaxID=10407 {ECO:0000313|EMBL:AGT38651.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN [1] {ECO:0000313|EMBL:AGT38651.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=EP0159 {ECO:0000313|EMBL:AGT38651.1};
RX PubMed=23936156;
RA Huang C.J., Wu C.F., Lan C.Y., Sung F.Y., Lin C.L., Liu C.J., Liu H.F.,
RA Yu M.W.;
RT "Impact of genetic heterogeneity in polymerase of hepatitis B virus on
RT dynamics of viral load and hepatitis B progression.";
RL PLoS ONE 8:E70169-E70169(2013).
RN [2] {ECO:0000313|EMBL:AGT38651.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=EP0159 {ECO:0000313|EMBL:AGT38651.1};
RA Huang C.-J., Wu C.-F., Lan C.-Y., Sung F.-Y., Lin C.-L., Liu C.-J.,
RA Liu H.-F., Yu M.-W.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000077};
CC -!- SIMILARITY: Belongs to the hepadnaviridae P protein family.
CC {ECO:0000256|ARBA:ARBA00007994}.
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DR EMBL; KC792806; AGT38651.1; -; Genomic_DNA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0039503; P:suppression by virus of host innate immune response; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 1.
DR HAMAP; MF_04073; HBV_DPOL; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001462; DNApol_viral_C.
DR InterPro; IPR000201; DNApol_viral_N.
DR InterPro; IPR037531; HBV_DPOL.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR Pfam; PF00336; DNA_pol_viral_C; 1.
DR Pfam; PF00242; DNA_pol_viral_N; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022632};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Inhibition of host innate immune response by virus
KW {ECO:0000256|ARBA:ARBA00022632};
KW Inhibition of host RLR pathway by virus {ECO:0000256|ARBA:ARBA00022482};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280}.
FT DOMAIN 334..577
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT REGION 180..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..225
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..246
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AGT38651.1"
SQ SEQUENCE 820 AA; 91630 MW; 8221D04D0372C146 CRC64;
LLLDDEAGPL EEELPRLADE GLNRRVAEDL NLGNINVSIP WTHKVGNFTG LYSSTVPVFN
PDWQTPSFPH IHLKEDIINR CQQYVGPLTS NEKRRLKLIM PARFYPNLTK YLPLEKGIKP
YYPEHAVNHY FKTMHYLHTL WEAGILYKRE TTRSASFCGS PYSWEQELQH GRLVFQTSTR
HGDESFRSQS SGILSRSSVG PGVRSQLKQS RLGLQPQQGS LARGKSGRSG SIRARVHSTT
RRSFGVEPSG SGHIDHSASS PSSCLHQSAV RKTAYSHLST SKRQSSSGHA VELHDIPTGC
WWLQFRNSKP CSDYCLSHIV NLLEDWGPCT EHGEHSIRIP RTPARVTGGV FLVDKNPHNA
TEARLVVDFS QFSRGSTQVS WPRFAVPNLQ SLTNLLSSNL SWLSLDVSAA FYHIPLHPAA
MPHLLVGSSG LPGYVARLSS TSRNINYQHG TMQDLHDSCS RNLFVSLLLL YKTFGRKLHL
YSHPIILGFR KIPMGVGLSP FLLAQFTSAI CSVVRRAFPH CLAFSYMDDI VLGAKSVQHL
ESLFTSITNF LMSLGIHLNP HKTKRWGYSL NFMGYVIGSW GTLPQEHIVL KIKQCFRKLP
VNRPIDWKVC QRIVGLLGFA APFTQCGYPA LKPLYACIQA KQAFTFSPTY KAFLCQQYLN
LYPVARQRSG LCQVFADATP TGWGLAIGHR RMRGTFVAPL PIHTAELLAA CFARSRSGAK
LIGTDNSVVL SRKYTSFPWL LGCAANWILR GTSFVYVPSA LNPADDPSRG RLGLYRPLLH
LPFRPTTGRT SLYAVSPSVP SHLPVRVHFA SPLHVAWRPP
//
