ID S5ZS64_HBV Unreviewed; 824 AA.
AC S5ZS64;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE RecName: Full=Protein P {ECO:0000256|ARBA:ARBA00021149};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:AGT38529.1};
OS Hepatitis B virus (HBV).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX NCBI_TaxID=10407 {ECO:0000313|EMBL:AGT38529.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN [1] {ECO:0000313|EMBL:AGT38529.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=EP0036 {ECO:0000313|EMBL:AGT38529.1};
RX PubMed=23936156;
RA Huang C.J., Wu C.F., Lan C.Y., Sung F.Y., Lin C.L., Liu C.J., Liu H.F.,
RA Yu M.W.;
RT "Impact of genetic heterogeneity in polymerase of hepatitis B virus on
RT dynamics of viral load and hepatitis B progression.";
RL PLoS ONE 8:E70169-E70169(2013).
RN [2] {ECO:0000313|EMBL:AGT38529.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=EP0036 {ECO:0000313|EMBL:AGT38529.1};
RA Huang C.-J., Wu C.-F., Lan C.-Y., Sung F.-Y., Lin C.-L., Liu C.-J.,
RA Liu H.-F., Yu M.-W.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000077};
CC -!- SIMILARITY: Belongs to the hepadnaviridae P protein family.
CC {ECO:0000256|ARBA:ARBA00007994}.
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DR EMBL; KC792683; AGT38529.1; -; Genomic_DNA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0039503; P:suppression by virus of host innate immune response; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 1.
DR HAMAP; MF_04073; HBV_DPOL; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001462; DNApol_viral_C.
DR InterPro; IPR000201; DNApol_viral_N.
DR InterPro; IPR037531; HBV_DPOL.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR Pfam; PF00336; DNA_pol_viral_C; 1.
DR Pfam; PF00242; DNA_pol_viral_N; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022632};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Inhibition of host innate immune response by virus
KW {ECO:0000256|ARBA:ARBA00022632};
KW Inhibition of host RLR pathway by virus {ECO:0000256|ARBA:ARBA00022482};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280}.
FT DOMAIN 338..581
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT REGION 174..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 191..219
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT UNSURE 39
FT /note="D or N"
FT /evidence="ECO:0000313|EMBL:AGT38529.1"
FT UNSURE 54
FT /note="D or N"
FT /evidence="ECO:0000313|EMBL:AGT38529.1"
FT UNSURE 380
FT /note="D or N"
FT /evidence="ECO:0000313|EMBL:AGT38529.1"
FT UNSURE 596
FT /note="I or L"
FT /evidence="ECO:0000313|EMBL:AGT38529.1"
FT UNSURE 725
FT /note="I or L"
FT /evidence="ECO:0000313|EMBL:AGT38529.1"
FT UNSURE 778
FT /note="I or L"
FT /evidence="ECO:0000313|EMBL:AGT38529.1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AGT38529.1"
SQ SEQUENCE 824 AA; 92212 MW; E5FA78FD9DCFBC71 CRC64;
PLEEELPRLA DEXLNRRVAE DLNLGNPNVS IPWTHKVGDF TGLYSSTVPC FNPDWQTPSF
PDIHLXEDIV DRCKQFVGPL TVNENRRLKL IMPARFYPNA TKYXPLDKGI KPYYPEHVVN
HYFKTRHYLH TLWKAGILYK RESTRSASFC GSPYSWEQDL QHGRLVFQTS KRHGDKSFCP
QSPGILPRSS VGPCIQSQLR KSRLGPQPSQ GQLAGXQQGG SGSFRARVHP SPWGTVGVEP
SGSGHTHNCA SSSSSCLHQS AVRKAAYSLL STSEGHSSSG RXVELHHFPP NSSRSQSQGP
XXSCWWLQFR NSEPCSXYCL YHIVNLIXDW GPCTEHGEHR IRTPRTPARV TGGVFLVDKN
PHNTTESRLV VDFSQFSRGD TRVSWPKFAV PNLQSLTNLL SSNLSWLSLD VSAAFYHLPL
HPAAMPHLLV GSSGLSRYVA RLSSNSRIID HQHGTMQNLH NSCSRNLYVS LMLLYKTYGR
KLHLYSHPII LGFRKIPMGV GLSPFLLAQF TSAICSVVRR AFPHCLAFSY MDDVVLGAKS
VQHLESLYAA VTNFLXSLGI HLNPHKTKRW GYSLNFMGYV IGXWGTLPQE HIVQKLKMCF
RKLPVNRPID WKVCQRIVGL LGFAAPFTQC GYPALMPLYA CIQAKQAFTF SPTYKAFLXX
QYLNLYPVAR QRSGLCQVFA DATPTGWGLA IGHQRMRGTF VSPLPIHTAE LLAACFARSR
SGANLIGTDN SVVLSRKYTS FPWLLGCAAN WILRGTSFVY VPSALNPADD PSRGRLGLYR
PLLRLXYRPT TGRXSLYADS PSVPXHLPDR VHFASPLHVA WRPP
//