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Database: UniProt
Entry: S5ZS64_HBV
LinkDB: S5ZS64_HBV
Original site: S5ZS64_HBV 
ID   S5ZS64_HBV              Unreviewed;       824 AA.
AC   S5ZS64;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   24-JAN-2024, entry version 46.
DE   RecName: Full=Protein P {ECO:0000256|ARBA:ARBA00021149};
DE            EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE   Flags: Fragment;
GN   Name=pol {ECO:0000313|EMBL:AGT38529.1};
OS   Hepatitis B virus (HBV).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX   NCBI_TaxID=10407 {ECO:0000313|EMBL:AGT38529.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN   [1] {ECO:0000313|EMBL:AGT38529.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=EP0036 {ECO:0000313|EMBL:AGT38529.1};
RX   PubMed=23936156;
RA   Huang C.J., Wu C.F., Lan C.Y., Sung F.Y., Lin C.L., Liu C.J., Liu H.F.,
RA   Yu M.W.;
RT   "Impact of genetic heterogeneity in polymerase of hepatitis B virus on
RT   dynamics of viral load and hepatitis B progression.";
RL   PLoS ONE 8:E70169-E70169(2013).
RN   [2] {ECO:0000313|EMBL:AGT38529.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=EP0036 {ECO:0000313|EMBL:AGT38529.1};
RA   Huang C.-J., Wu C.-F., Lan C.-Y., Sung F.-Y., Lin C.-L., Liu C.-J.,
RA   Liu H.-F., Yu M.-W.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00000077};
CC   -!- SIMILARITY: Belongs to the hepadnaviridae P protein family.
CC       {ECO:0000256|ARBA:ARBA00007994}.
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DR   EMBL; KC792683; AGT38529.1; -; Genomic_DNA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0039503; P:suppression by virus of host innate immune response; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.270; -; 1.
DR   HAMAP; MF_04073; HBV_DPOL; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR001462; DNApol_viral_C.
DR   InterPro; IPR000201; DNApol_viral_N.
DR   InterPro; IPR037531; HBV_DPOL.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR000477; RT_dom.
DR   Pfam; PF00336; DNA_pol_viral_C; 1.
DR   Pfam; PF00242; DNA_pol_viral_N; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   3: Inferred from homology;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Host-virus interaction {ECO:0000256|ARBA:ARBA00022632};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Inhibition of host innate immune response by virus
KW   {ECO:0000256|ARBA:ARBA00022632};
KW   Inhibition of host RLR pathway by virus {ECO:0000256|ARBA:ARBA00022482};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280}.
FT   DOMAIN          338..581
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   REGION          174..246
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        191..219
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   UNSURE          39
FT                   /note="D or N"
FT                   /evidence="ECO:0000313|EMBL:AGT38529.1"
FT   UNSURE          54
FT                   /note="D or N"
FT                   /evidence="ECO:0000313|EMBL:AGT38529.1"
FT   UNSURE          380
FT                   /note="D or N"
FT                   /evidence="ECO:0000313|EMBL:AGT38529.1"
FT   UNSURE          596
FT                   /note="I or L"
FT                   /evidence="ECO:0000313|EMBL:AGT38529.1"
FT   UNSURE          725
FT                   /note="I or L"
FT                   /evidence="ECO:0000313|EMBL:AGT38529.1"
FT   UNSURE          778
FT                   /note="I or L"
FT                   /evidence="ECO:0000313|EMBL:AGT38529.1"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AGT38529.1"
SQ   SEQUENCE   824 AA;  92212 MW;  E5FA78FD9DCFBC71 CRC64;
     PLEEELPRLA DEXLNRRVAE DLNLGNPNVS IPWTHKVGDF TGLYSSTVPC FNPDWQTPSF
     PDIHLXEDIV DRCKQFVGPL TVNENRRLKL IMPARFYPNA TKYXPLDKGI KPYYPEHVVN
     HYFKTRHYLH TLWKAGILYK RESTRSASFC GSPYSWEQDL QHGRLVFQTS KRHGDKSFCP
     QSPGILPRSS VGPCIQSQLR KSRLGPQPSQ GQLAGXQQGG SGSFRARVHP SPWGTVGVEP
     SGSGHTHNCA SSSSSCLHQS AVRKAAYSLL STSEGHSSSG RXVELHHFPP NSSRSQSQGP
     XXSCWWLQFR NSEPCSXYCL YHIVNLIXDW GPCTEHGEHR IRTPRTPARV TGGVFLVDKN
     PHNTTESRLV VDFSQFSRGD TRVSWPKFAV PNLQSLTNLL SSNLSWLSLD VSAAFYHLPL
     HPAAMPHLLV GSSGLSRYVA RLSSNSRIID HQHGTMQNLH NSCSRNLYVS LMLLYKTYGR
     KLHLYSHPII LGFRKIPMGV GLSPFLLAQF TSAICSVVRR AFPHCLAFSY MDDVVLGAKS
     VQHLESLYAA VTNFLXSLGI HLNPHKTKRW GYSLNFMGYV IGXWGTLPQE HIVQKLKMCF
     RKLPVNRPID WKVCQRIVGL LGFAAPFTQC GYPALMPLYA CIQAKQAFTF SPTYKAFLXX
     QYLNLYPVAR QRSGLCQVFA DATPTGWGLA IGHQRMRGTF VSPLPIHTAE LLAACFARSR
     SGANLIGTDN SVVLSRKYTS FPWLLGCAAN WILRGTSFVY VPSALNPADD PSRGRLGLYR
     PLLRLXYRPT TGRXSLYADS PSVPXHLPDR VHFASPLHVA WRPP
//
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