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Database: UniProt
Entry: S5ZSH9_HBV
LinkDB: S5ZSH9_HBV
Original site: S5ZSH9_HBV 
ID   S5ZSH9_HBV              Unreviewed;       827 AA.
AC   S5ZSH9;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   24-JAN-2024, entry version 45.
DE   RecName: Full=Protein P {ECO:0000256|ARBA:ARBA00021149};
DE            EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE   Flags: Fragment;
GN   Name=pol {ECO:0000313|EMBL:AGT38639.1};
OS   Hepatitis B virus (HBV).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX   NCBI_TaxID=10407 {ECO:0000313|EMBL:AGT38639.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN   [1] {ECO:0000313|EMBL:AGT38639.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=EP0147 {ECO:0000313|EMBL:AGT38639.1};
RX   PubMed=23936156;
RA   Huang C.J., Wu C.F., Lan C.Y., Sung F.Y., Lin C.L., Liu C.J., Liu H.F.,
RA   Yu M.W.;
RT   "Impact of genetic heterogeneity in polymerase of hepatitis B virus on
RT   dynamics of viral load and hepatitis B progression.";
RL   PLoS ONE 8:E70169-E70169(2013).
RN   [2] {ECO:0000313|EMBL:AGT38639.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=EP0147 {ECO:0000313|EMBL:AGT38639.1};
RA   Huang C.-J., Wu C.-F., Lan C.-Y., Sung F.-Y., Lin C.-L., Liu C.-J.,
RA   Liu H.-F., Yu M.-W.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00000077};
CC   -!- SIMILARITY: Belongs to the hepadnaviridae P protein family.
CC       {ECO:0000256|ARBA:ARBA00007994}.
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DR   EMBL; KC792794; AGT38639.1; -; Genomic_DNA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0039503; P:suppression by virus of host innate immune response; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.270; -; 1.
DR   HAMAP; MF_04073; HBV_DPOL; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR001462; DNApol_viral_C.
DR   InterPro; IPR000201; DNApol_viral_N.
DR   InterPro; IPR037531; HBV_DPOL.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR000477; RT_dom.
DR   Pfam; PF00336; DNA_pol_viral_C; 1.
DR   Pfam; PF00242; DNA_pol_viral_N; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   3: Inferred from homology;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Host-virus interaction {ECO:0000256|ARBA:ARBA00022632};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Inhibition of host innate immune response by virus
KW   {ECO:0000256|ARBA:ARBA00022632};
KW   Inhibition of host RLR pathway by virus {ECO:0000256|ARBA:ARBA00022482};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280}.
FT   DOMAIN          341..584
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   REGION          177..253
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AGT38639.1"
SQ   SEQUENCE   827 AA;  92254 MW;  58A194244BFF40F4 CRC64;
     EAGPLEEELP RLADEGLNRR VAEDLNLGNL DVSIPWTHKV GNFTGLYSST VPCFNPKWQT
     PSFPDIHLKE DIVDRCQQFV GPLTVNENRR LKLIMPARFY PKVTKYLPLD KGIKPYYPEY
     VVNHYFQTRH YLHTLWKAGI LYKRESTRSA SFCGSPYSWE QDLQHGRLVF QTSKRHGDKS
     FCPQSPGILP RSSVGPCIQS QLRKPRLGPQ PAQGQLAGRQ QGGSGSIRAR VHPSPRGIVG
     VEPSGSGPTH NCASSSSSCL HQSAVRKAAY SLIXTSKGHS SSGHAVELHH FPPNSSRSQS
     QGPVLSCWWL QFRNSEPCSE YCLCHIVNLI EDWGPCTEHG EHRIRTPRTP ARVTGGVFLV
     DKNPHNTTES RLVVDFSQFS RGNTRVSWPK FAVPNLQSLT NLLSSNLSWL SLDVSAAFYH
     IPLHPAAMPH LLVGSSGLSR YVARLSSNSR IINNQHRTMQ NLHNSCSRNL XVSLMLLYKT
     YGRKLHLYSH PIILGFRKIP MGVGLSPFLL AQFTSAICSV VRRAFPHCLA FSYMDDLVLG
     AKSVHHLESL YAAVTNFLLS LGIHLNPHKT KRWGYSLNFM GYVIGSWGTL PQEHIVQKIK
     MCFRKLPVNR PIDWKVCQRI VGLLGFAAPF TQCGYPALMP LYACIQAKQA FTFSPTYKAF
     LSKQYLNLYP VARQRSGLCQ VFADATPTGW GLAIGHQRVR GTFVSPLPIH TAELLAACFA
     RSRSGANLIG TDNSVVLSRK YTSFPWLLGC AANWILRGTS FVYVPSALNP ADDPSRGRLG
     LCRPLLRLLF QPTTGRTSLY ADSPSVPSHL PDRVHFASPL HVAWRPP
//
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