ID S5ZSH9_HBV Unreviewed; 827 AA.
AC S5ZSH9;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE RecName: Full=Protein P {ECO:0000256|ARBA:ARBA00021149};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:AGT38639.1};
OS Hepatitis B virus (HBV).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX NCBI_TaxID=10407 {ECO:0000313|EMBL:AGT38639.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN [1] {ECO:0000313|EMBL:AGT38639.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=EP0147 {ECO:0000313|EMBL:AGT38639.1};
RX PubMed=23936156;
RA Huang C.J., Wu C.F., Lan C.Y., Sung F.Y., Lin C.L., Liu C.J., Liu H.F.,
RA Yu M.W.;
RT "Impact of genetic heterogeneity in polymerase of hepatitis B virus on
RT dynamics of viral load and hepatitis B progression.";
RL PLoS ONE 8:E70169-E70169(2013).
RN [2] {ECO:0000313|EMBL:AGT38639.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=EP0147 {ECO:0000313|EMBL:AGT38639.1};
RA Huang C.-J., Wu C.-F., Lan C.-Y., Sung F.-Y., Lin C.-L., Liu C.-J.,
RA Liu H.-F., Yu M.-W.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000077};
CC -!- SIMILARITY: Belongs to the hepadnaviridae P protein family.
CC {ECO:0000256|ARBA:ARBA00007994}.
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DR EMBL; KC792794; AGT38639.1; -; Genomic_DNA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0039503; P:suppression by virus of host innate immune response; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 1.
DR HAMAP; MF_04073; HBV_DPOL; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001462; DNApol_viral_C.
DR InterPro; IPR000201; DNApol_viral_N.
DR InterPro; IPR037531; HBV_DPOL.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR Pfam; PF00336; DNA_pol_viral_C; 1.
DR Pfam; PF00242; DNA_pol_viral_N; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022632};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Inhibition of host innate immune response by virus
KW {ECO:0000256|ARBA:ARBA00022632};
KW Inhibition of host RLR pathway by virus {ECO:0000256|ARBA:ARBA00022482};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280}.
FT DOMAIN 341..584
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT REGION 177..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AGT38639.1"
SQ SEQUENCE 827 AA; 92254 MW; 58A194244BFF40F4 CRC64;
EAGPLEEELP RLADEGLNRR VAEDLNLGNL DVSIPWTHKV GNFTGLYSST VPCFNPKWQT
PSFPDIHLKE DIVDRCQQFV GPLTVNENRR LKLIMPARFY PKVTKYLPLD KGIKPYYPEY
VVNHYFQTRH YLHTLWKAGI LYKRESTRSA SFCGSPYSWE QDLQHGRLVF QTSKRHGDKS
FCPQSPGILP RSSVGPCIQS QLRKPRLGPQ PAQGQLAGRQ QGGSGSIRAR VHPSPRGIVG
VEPSGSGPTH NCASSSSSCL HQSAVRKAAY SLIXTSKGHS SSGHAVELHH FPPNSSRSQS
QGPVLSCWWL QFRNSEPCSE YCLCHIVNLI EDWGPCTEHG EHRIRTPRTP ARVTGGVFLV
DKNPHNTTES RLVVDFSQFS RGNTRVSWPK FAVPNLQSLT NLLSSNLSWL SLDVSAAFYH
IPLHPAAMPH LLVGSSGLSR YVARLSSNSR IINNQHRTMQ NLHNSCSRNL XVSLMLLYKT
YGRKLHLYSH PIILGFRKIP MGVGLSPFLL AQFTSAICSV VRRAFPHCLA FSYMDDLVLG
AKSVHHLESL YAAVTNFLLS LGIHLNPHKT KRWGYSLNFM GYVIGSWGTL PQEHIVQKIK
MCFRKLPVNR PIDWKVCQRI VGLLGFAAPF TQCGYPALMP LYACIQAKQA FTFSPTYKAF
LSKQYLNLYP VARQRSGLCQ VFADATPTGW GLAIGHQRVR GTFVSPLPIH TAELLAACFA
RSRSGANLIG TDNSVVLSRK YTSFPWLLGC AANWILRGTS FVYVPSALNP ADDPSRGRLG
LCRPLLRLLF QPTTGRTSLY ADSPSVPSHL PDRVHFASPL HVAWRPP
//