ID   S5ZTL0_HBV              Unreviewed;       831 AA.
AC   S5ZTL0;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   24-JAN-2024, entry version 46.
DE   RecName: Full=Protein P {ECO:0000256|ARBA:ARBA00021149};
DE            EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE   Flags: Fragment;
GN   Name=pol {ECO:0000313|EMBL:AGT38989.1};
OS   Hepatitis B virus (HBV).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX   NCBI_TaxID=10407 {ECO:0000313|EMBL:AGT38989.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN   [1] {ECO:0000313|EMBL:AGT38989.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=EP0500 {ECO:0000313|EMBL:AGT38989.1};
RX   PubMed=23936156;
RA   Huang C.J., Wu C.F., Lan C.Y., Sung F.Y., Lin C.L., Liu C.J., Liu H.F.,
RA   Yu M.W.;
RT   "Impact of genetic heterogeneity in polymerase of hepatitis B virus on
RT   dynamics of viral load and hepatitis B progression.";
RL   PLoS ONE 8:E70169-E70169(2013).
RN   [2] {ECO:0000313|EMBL:AGT38989.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=EP0500 {ECO:0000313|EMBL:AGT38989.1};
RA   Huang C.-J., Wu C.-F., Lan C.-Y., Sung F.-Y., Lin C.-L., Liu C.-J.,
RA   Liu H.-F., Yu M.-W.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00000077};
CC   -!- SIMILARITY: Belongs to the hepadnaviridae P protein family.
CC       {ECO:0000256|ARBA:ARBA00007994}.
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DR   EMBL; KC793147; AGT38989.1; -; Genomic_DNA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0039503; P:suppression by virus of host innate immune response; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.270; -; 1.
DR   HAMAP; MF_04073; HBV_DPOL; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR001462; DNApol_viral_C.
DR   InterPro; IPR000201; DNApol_viral_N.
DR   InterPro; IPR037531; HBV_DPOL.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR000477; RT_dom.
DR   Pfam; PF00336; DNA_pol_viral_C; 1.
DR   Pfam; PF00242; DNA_pol_viral_N; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   3: Inferred from homology;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Host-virus interaction {ECO:0000256|ARBA:ARBA00022632};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Inhibition of host innate immune response by virus
KW   {ECO:0000256|ARBA:ARBA00022632};
KW   Inhibition of host RLR pathway by virus {ECO:0000256|ARBA:ARBA00022482};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280}.
FT   DOMAIN          345..588
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   REGION          180..251
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        198..226
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AGT38989.1"
SQ   SEQUENCE   831 AA;  93229 MW;  4E2956FF6A2ABE55 CRC64;
     LLDEEAGPLE EELPRLADEG LNRRVAEELN LGNLNVSIPW THKVGNFTGL YSSTVPCFNS
     NWQTPSFPDI HLQEDIVDRC EQFVGPLTVN ENRRLKLIMP ARFYPNVTKY LPLDKGIKPY
     YPEHVVNHYF QTRHYLHTLW KAGILYKRES TRSASFCGSP YSWEQDLQHG RLVFQTSKRH
     GDKSFYPQSP GILPRSSVGP CIQSQLRKSR LGPQPTQGQL AGRQQGGSRS IRARVRPSPW
     GTVGVEPSGS GHTHNCASSS SSCLHQSAVR KAAYSLISTS KGHSSSGHEV ELHHFPPNSS
     RSQSQGPVLS CWWLQFRNSE PCSEYCLCHI VNFIEDWGPC TEHGEHRIRT PRTPTRVTGG
     VFLVDKNPHN TTESRLVVDF SQFSRGNTRV SWPKFAVPNL QSLTNLLSSN LSWLSLDVSA
     AFYHLPLHPA AMPHLLVGSS GLSRYVARLS SNSRIINNQH RTMQXLHNSC SRNLYVSLML
     LXKTYGRKLH LYSHPIIFGF RKIPMGVGLS PFLLAQFTSA ICSVVRRAFP HCLAFSYMDD
     VVLGAKSVQH LESLYAAVTN FLLSLGIHLN PHKTKRWGYS LHFMGYVIGC WGTLPQEHIV
     QKIKMCFRKL PVNRPIDWKV CQRIVGLLGF AAPFTQCGYP ALMPLYACIQ AKQAFTFSPT
     YKAFLSKQYL NLYPVARQRS GLCQVFADAT PTGWGLAIGH QRMRGTFVSP LPIHTAELLA
     ACFARSRSGA KLIGTDNSVV LSRKYTSFPW LLGCAANWIL RGTSFVYVPS ALNPADDPSR
     GRLGLYRPLL RLMYRPSTGR TSLYADSPSV PSHLPDRVHF ASPLHVAWRP P
//