ID S5ZZI5_HBV Unreviewed; 831 AA.
AC S5ZZI5;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE RecName: Full=Protein P {ECO:0000256|ARBA:ARBA00021149};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:AGT38497.1};
OS Hepatitis B virus (HBV).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX NCBI_TaxID=10407 {ECO:0000313|EMBL:AGT38497.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN [1] {ECO:0000313|EMBL:AGT38497.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=EP0004 {ECO:0000313|EMBL:AGT38497.1};
RX PubMed=23936156;
RA Huang C.J., Wu C.F., Lan C.Y., Sung F.Y., Lin C.L., Liu C.J., Liu H.F.,
RA Yu M.W.;
RT "Impact of genetic heterogeneity in polymerase of hepatitis B virus on
RT dynamics of viral load and hepatitis B progression.";
RL PLoS ONE 8:E70169-E70169(2013).
RN [2] {ECO:0000313|EMBL:AGT38497.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=EP0004 {ECO:0000313|EMBL:AGT38497.1};
RA Huang C.-J., Wu C.-F., Lan C.-Y., Sung F.-Y., Lin C.-L., Liu C.-J.,
RA Liu H.-F., Yu M.-W.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000077};
CC -!- SIMILARITY: Belongs to the hepadnaviridae P protein family.
CC {ECO:0000256|ARBA:ARBA00007994}.
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DR EMBL; KC792651; AGT38497.1; -; Genomic_DNA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0039503; P:suppression by virus of host innate immune response; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 1.
DR HAMAP; MF_04073; HBV_DPOL; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001462; DNApol_viral_C.
DR InterPro; IPR000201; DNApol_viral_N.
DR InterPro; IPR037531; HBV_DPOL.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR Pfam; PF00336; DNA_pol_viral_C; 1.
DR Pfam; PF00242; DNA_pol_viral_N; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022632};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Inhibition of host innate immune response by virus
KW {ECO:0000256|ARBA:ARBA00022632};
KW Inhibition of host RLR pathway by virus {ECO:0000256|ARBA:ARBA00022482};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280}.
FT DOMAIN 345..588
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT REGION 178..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..224
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT UNSURE 425
FT /note="I or L"
FT /evidence="ECO:0000313|EMBL:AGT38497.1"
FT UNSURE 468
FT /note="D or N"
FT /evidence="ECO:0000313|EMBL:AGT38497.1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AGT38497.1"
SQ SEQUENCE 831 AA; 92932 MW; 353E3F98CEEDEFA4 CRC64;
LLDEEAGPLE EELPRLADEG LNRRVAEDLN LGNLNVSIPW THKVGNFTGL YSSTVPCFNP
KWQTPSFPDI HLQEDIVDRC KQFVGPLTVN ENRRLKLIMP ARFYPXVTKY LPLDKGIKPY
YPEHVVNHYF QTRHYLHTLW KAGILYKRES TRSASFCGSP YSWEQDLQHG RLXFQTSKRH
GDKSFCPQSP GIPPRSSVGP CIQSQLRKSR LGPQPAQGQL AGRQQGGSGX IRARVHXAPW
GTVGVEPSGS GHTYNCASSS SSCLHQSAVR KAAYSLISTS KGHSSSGHAV EFHHFPPNSS
RSQSQGSVLP CWWLQFRTSE PCSXYCLCHI VNLIEDWGPC TEHGEHXIRT PRTPARVTGG
VFLVDKNPHN TTESRLVVDF SQFSRGNTRV SWPKFAVPNL QSLTNLLSSN LSWLSLDVSA
AFYHLPLHPA AMPHLLVGSS GLSRYVARLS SNSRIINNQH RTMQNLHDSC SRNLYVSLML
LYKTYGRKLH LYSHPIILGF RKIPMGVGLS PFLLAQFTSA ICSVVRRAFP HCLAFSYMDD
XVLGAKSVQH LESLYAAVTH FLLSLGIHLN PHKTKRWGYS LNFMGYVIGS WGTLPQEHIV
QKIKMCFRKL PVNRPIDWKV CQRIVGLLGF AAPFTQCGYP ALMPLYACIQ AKQAFTFSPT
YKAFLSKQYL NLYPVARQRP GLCQVFADAT PTGWGLAIGH QRMRGTFVSP LPIHTAELLA
ACFARSRSGA KLIGTDNSVV LSRKYTSFPW LLGCAANWIL RGTSFVYVPS ALNPADDPSR
GRLGLYRPLL RLLYRPTTGR TSLYADSPSV PSHLPDRVHF ASPLHVAWRP P
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