ID S6A083_HBV Unreviewed; 827 AA.
AC S6A083;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 46.
DE RecName: Full=Protein P {ECO:0000256|ARBA:ARBA00021149};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:AGT38952.1};
OS Hepatitis B virus (HBV).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX NCBI_TaxID=10407 {ECO:0000313|EMBL:AGT38952.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN [1] {ECO:0000313|EMBL:AGT38952.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=EP0461 {ECO:0000313|EMBL:AGT38952.1};
RX PubMed=23936156;
RA Huang C.J., Wu C.F., Lan C.Y., Sung F.Y., Lin C.L., Liu C.J., Liu H.F.,
RA Yu M.W.;
RT "Impact of genetic heterogeneity in polymerase of hepatitis B virus on
RT dynamics of viral load and hepatitis B progression.";
RL PLoS ONE 8:E70169-E70169(2013).
RN [2] {ECO:0000313|EMBL:AGT38952.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=EP0461 {ECO:0000313|EMBL:AGT38952.1};
RA Huang C.-J., Wu C.-F., Lan C.-Y., Sung F.-Y., Lin C.-L., Liu C.-J.,
RA Liu H.-F., Yu M.-W.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000077};
CC -!- SIMILARITY: Belongs to the hepadnaviridae P protein family.
CC {ECO:0000256|ARBA:ARBA00007994}.
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DR EMBL; KC793108; AGT38952.1; -; Genomic_DNA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0039503; P:suppression by virus of host innate immune response; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 1.
DR HAMAP; MF_04073; HBV_DPOL; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001462; DNApol_viral_C.
DR InterPro; IPR000201; DNApol_viral_N.
DR InterPro; IPR037531; HBV_DPOL.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR Pfam; PF00336; DNA_pol_viral_C; 1.
DR Pfam; PF00242; DNA_pol_viral_N; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022632};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Inhibition of host innate immune response by virus
KW {ECO:0000256|ARBA:ARBA00022632};
KW Inhibition of host RLR pathway by virus {ECO:0000256|ARBA:ARBA00022482};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280}.
FT DOMAIN 341..584
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT REGION 200..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 274..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..220
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AGT38952.1"
SQ SEQUENCE 827 AA; 92420 MW; 7F91F898CD05B781 CRC64;
EAGPLEDELP RLADEGLNRR VAEDLNLGDL NVSIPWTHKV GNFTGLYSST VPVFNPEWQT
PSFPHIHLQE DIIDRCQQYV GPLTVNEKRR LKLIMPARFY PNMTKYLPLD KGIKPYYPEH
AVNHYFKTRH YLHTLWKAGI LYKRETTRSA SFYGSPYSWE QELQHGRLVC QTSTRHGDES
FCSQSSGILS RSPVGPCVRS QLKQSRLGLQ PQQGSLARGK SGRSGSIRAR VHPTXRRSFG
VEPSGSGHID NSASSTSSCL HQSAVRETAY SHLSTSKRQS SSGHAVELHN IPPSSARSQS
EGPISSCWWL QFRNSKPCSD YCLTHIVNLL EDWGPCTEHG EHNIRIPRTP ARVTGGVFLV
DKNPHNTTES RLVVDFSQFS RGSTHVSWPK FAVPNLQSLT NLLSSNLSWL SLDVSAAFYH
IPLHPAAMPH LLVGSSGLPR YVARLSSTSR NINHQHGAMQ DLHDSCSRNL YVSLLLLYKT
FGRKLHLYSH PIILGFRKIP MGVGLSPFLL AQFTSAICSV VRRAFPHCLA FSYMDDVVLG
AKSVQHLEAL FTSITNFLLS LGIHLNPNKT KRWGYSLNFM GYVIGSWGTL PQEHIVLKLK
QCFRKLPVNR PIDWKVCQRI VGLLGFAAPF TQCGYPALMP LYACIQSKQA FTFSPTYKAF
LCKQYMNLYP VARQRSGLCQ VFADATPTGW GLAIGHQRMR GTFVAPLPIH TAELLAACFA
RSRSGAKLIG TDNSVVLSRK YTSFPWLLGC AANWILRGTS FVYVPSALNP ADDPSRGRLG
LYRPLLRLPF RPTTGRTSLY AVSPSVPSHL PVRVHFASPL HVAWRPP
//
