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Database: UniProt
Entry: S6CKB5_9ACTN
LinkDB: S6CKB5_9ACTN
Original site: S6CKB5_9ACTN 
ID   S6CKB5_9ACTN            Unreviewed;       542 AA.
AC   S6CKB5;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   05-JUL-2017, entry version 32.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=AEQU_0001 {ECO:0000313|EMBL:BAN75970.1};
OS   Adlercreutzia equolifaciens DSM 19450.
OC   Bacteria; Actinobacteria; Coriobacteriia; Eggerthellales;
OC   Eggerthellaceae; Adlercreutzia.
OX   NCBI_TaxID=1384484 {ECO:0000313|EMBL:BAN75970.1, ECO:0000313|Proteomes:UP000015924};
RN   [1] {ECO:0000313|EMBL:BAN75970.1, ECO:0000313|Proteomes:UP000015924}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 19450 {ECO:0000313|EMBL:BAN75970.1};
RA   Toh H., Oshima K., Suzuki T., Hattori M., Morita H.;
RT   "Complete Genome Sequence of the Equol-Producing Bacterium
RT   Adlercreutzia equolifaciens DSM 19450T.";
RL   Genome Announc. 1:e00742-13(2013).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; AP013105; BAN75970.1; -; Genomic_DNA.
DR   RefSeq; WP_022737974.1; NC_022567.1.
DR   EnsemblBacteria; BAN75970; BAN75970; AEQU_0001.
DR   KEGG; aeq:AEQU_0001; -.
DR   PATRIC; fig|1384484.3.peg.1; -.
DR   KO; K02313; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000015924; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000015924};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000015924}.
FT   DOMAIN      225    363       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      449    517       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     233    240       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   542 AA;  60238 MW;  42CB18774B9A140A CRC64;
     MDSETLNEQW ARICAQVKSY QDIDPSQVSA FFSRLVPQAM SDSFLMLTAD NDFIKTWVEQ
     HYTEVIVRAL RDLTGVVFAV AIAVDPTQEQ RKSAAVAQPS PAAPLSAPSQ PMPAPAPAQP
     AATTMEPLPS QPIAASAPPP PAYGAPLSQA APFEPSGMVA HPLVEDVVVD HYAPPAPAPL
     SQEPVAERSS NPSSSLTFEN FVIGESNRMA YSMAVEVAES PGRLPLNPLF IYGKSGLGKT
     HLMRAIQNYI EETRPSMRTV YVDAQDFVSK YSEAGAIKDQ EKVSFRNFRA YYEQADILLL
     DDVQHLQGKK ESMNMLFQLF NTLTSQGKQV VLSADRAPKN IQFDERLKSR FYSGGTIDIQ
     PPEVETKLGI VKSFTDEFSR SEGLGNFTLS DDIQMYIAEN SGSNIRELKG AVNTVIYRMI
     YCDRSDISID EVRELLANHF TGGMSRSLTV EDIQREVENF FKVSHSDMVG PKRSQSIVRP
     RQIAIYLCRQ LLDLPYGDIG KKFNRDHSTA IHSATSIEER LKTDRDTQEE IEVLQKIICE
     LD
//
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