ID S6DB06_9VIRU Unreviewed; 190 AA.
AC S6DB06;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Thymidine kinase {ECO:0000313|EMBL:CCV01826.1};
GN Name=149R {ECO:0000313|EMBL:CCV01826.1};
GN ORFNames=IIV22_149R {ECO:0000313|EMBL:CCV01826.1};
OS Invertebrate iridovirus 22.
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC Pimascovirales; Iridoviridae; Betairidovirinae; Chloriridovirus.
OX NCBI_TaxID=1301279 {ECO:0000313|EMBL:CCV01826.1, ECO:0000313|Proteomes:UP000154968};
RN [1] {ECO:0000313|EMBL:CCV01826.1, ECO:0000313|Proteomes:UP000154968}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23804567; DOI=10.1099/vir.0.054213-0;
RA Piegu B., Guizard S., Spears T., Cruaud C., Couloux A., Bideshi D.K.,
RA Federici B.A., Bigot Y.;
RT "Complete genome sequence of invertebrate iridescent virus 22 isolated from
RT a blackfly larva.";
RL J. Gen. Virol. 94:2112-2116(2013).
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DR EMBL; HF920633; CCV01826.1; -; Genomic_DNA.
DR RefSeq; YP_008357447.1; NC_021901.1.
DR GeneID; 16414488; -.
DR KEGG; vg:16414488; -.
DR Proteomes; UP000154968; Genome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0019136; F:deoxynucleoside kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR002624; DCK/DGK.
DR InterPro; IPR031314; DNK_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10513; DEOXYNUCLEOSIDE KINASE; 1.
DR PANTHER; PTHR10513:SF35; THYMIDINE KINASE 2, MITOCHONDRIAL; 1.
DR Pfam; PF01712; dNK; 1.
DR PIRSF; PIRSF000705; DNK; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR000705-3};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:CCV01826.1};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR000705-3};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 5..174
FT /note="Deoxynucleoside kinase"
FT /evidence="ECO:0000259|Pfam:PF01712"
FT ACT_SITE 78
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000705-1"
FT BINDING 9..17
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000705-3"
FT BINDING 133..137
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000705-3"
SQ SEQUENCE 190 AA; 22458 MW; 99B45B6BF23BA1E2 CRC64;
MVYIITIDGA IGAGKSSLIS QLKDDFTCFQ EPVEEWSLLQ NFYENMPEFA APFQYQVLFS
FHKLYSTFKN VQDKVILERC PWSSKNIFTQ LLVESGHINQ EEYQLYCNFY NKIAFTTNLY
VYLKVDTDVA YRRILNRDRA AERSLTFEYL EILNNKYNES LKTLENVKII DANKPLNEIK
YEVIDLLHKI
//
