ID S6DQ91_CAEEL Unreviewed; 555 AA.
AC S6DQ91;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Major facilitator superfamily (MFS) profile domain-containing protein {ECO:0000313|EMBL:CCW46023.1};
GN Name=eat-4 {ECO:0000313|EMBL:CCW46023.1,
GN ECO:0000313|WormBase:ZK512.6b};
GN ORFNames=CELE_ZK512.6 {ECO:0000313|EMBL:CCW46023.1}, ZK512.6
GN {ECO:0000313|WormBase:ZK512.6b};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCW46023.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCW46023.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCW46023.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; BX284603; CCW46023.1; -; Genomic_DNA.
DR RefSeq; NP_001293625.1; NM_001306696.1.
DR AlphaFoldDB; S6DQ91; -.
DR SMR; S6DQ91; -.
DR EPD; S6DQ91; -.
DR EnsemblMetazoa; ZK512.6b.1; ZK512.6b.1; WBGene00001135.
DR GeneID; 176291; -.
DR AGR; WB:WBGene00001135; -.
DR WormBase; ZK512.6b; CE48482; WBGene00001135; eat-4.
DR GeneTree; ENSGT00940000170115; -.
DR HOGENOM; CLU_001265_5_0_1; -.
DR OrthoDB; 2685946at2759; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00001135; Expressed in larva and 3 other cell types or tissues.
DR ExpressionAtlas; S6DQ91; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd17382; MFS_SLC17A6_7_8_VGluT; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR11662; SOLUTE CARRIER FAMILY 17; 1.
DR PANTHER; PTHR11662:SF418; VESICULAR GLUTAMATE TRANSPORTER, ISOFORM A; 1.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
PE 4: Predicted;
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00023201}.
FT TRANSMEM 49..71
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 105..122
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 129..148
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 154..178
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 190..216
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 222..241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 286..304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 324..341
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 361..380
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 386..404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 416..438
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 450..470
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 50..475
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 555 AA; 60706 MW; FA2652BFA4F597A5 CRC64;
MTAAAASATG AAPPQQMQEE GNENPMQMHS NKVLQVMEQT WIGKCRKRWL LAILANMGFM
ISFGIRCNFG AAKTHMYKNY TDPYGKVHMH EFNWTIDELS VMESSYFYGY LVTQIPAGFL
AAKFPPNKLF GFGIGVGAFL NILLPYGFKV KSDYLVAFIQ ITQGLVQGVC YPAMHGVWRY
WAPPMERSKL ATTAFTGSYA GAVLGLPLSA FLVSYVSWAA PFYLYGVCGV IWAILWFCVT
FEKPAFHPTI SQEEKIFIED AIGHVSNTHP TIRSIPWKAI VTSKPVWAII VANFARSWTF
YLLLQNQLTY MKEALGMKIA DSGLLAAIPH LVMGCVVLMG GQLADYLRSN KILSTTAVRK
IFNCGGFGGE AAFMLIVAYT TSDTTAIMAL IAAVGMSGFA ISGFNVNHLD IAPRYAAILM
GFSNGIGTLA GLTCPFVTEA FTAHSKHGWT SVFLLASLIH FTGVTFYAVY ASGELQEWAE
PKEEEEWSNK ELVNKTGING TGYGAAETTF TQLPAGVDSS YQAQAAPAPG TNPFASAWDE
HGSSGVVENP HYQQW
//
