ID S6FQX1_LACLL Unreviewed; 493 AA.
AC S6FQX1;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Galactose-1-phosphate uridylyltransferase {ECO:0000256|HAMAP-Rule:MF_00571};
DE Short=Gal-1-P uridylyltransferase {ECO:0000256|HAMAP-Rule:MF_00571};
DE EC=2.7.7.12 {ECO:0000256|HAMAP-Rule:MF_00571};
DE AltName: Full=UDP-glucose--hexose-1-phosphate uridylyltransferase {ECO:0000256|HAMAP-Rule:MF_00571};
GN Name=galT {ECO:0000256|HAMAP-Rule:MF_00571,
GN ECO:0000313|EMBL:CDG03422.1};
GN ORFNames=O9U_04840 {ECO:0000313|EMBL:CDG03422.1};
OS Lactococcus lactis subsp. lactis A12.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Lactococcus.
OX NCBI_TaxID=1137134 {ECO:0000313|EMBL:CDG03422.1, ECO:0000313|Proteomes:UP000015361};
RN [1] {ECO:0000313|EMBL:CDG03422.1, ECO:0000313|Proteomes:UP000015361}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A12 {ECO:0000313|EMBL:CDG03422.1,
RC ECO:0000313|Proteomes:UP000015361};
RX PubMed=23872564; DOI=10.1128/AEM.01560-13;
RA Passerini D., Coddeville M., Le Bourgeois P., Loubiere P., Ritzenthaler P.,
RA Fontagne-Faucher C., Daveran-Mingot M.L., Cocaign-Bousquet M.;
RT "The Carbohydrate Metabolism Signature of Lactococcus lactis Strain A12
RT Reveals Its Sourdough Ecosystem Origin.";
RL Appl. Environ. Microbiol. 79:5844-5852(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-
CC glucose 1-phosphate + UDP-alpha-D-galactose; Xref=Rhea:RHEA:13989,
CC ChEBI:CHEBI:58336, ChEBI:CHEBI:58601, ChEBI:CHEBI:58885,
CC ChEBI:CHEBI:66914; EC=2.7.7.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001107, ECO:0000256|HAMAP-
CC Rule:MF_00571};
CC -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC {ECO:0000256|ARBA:ARBA00004947, ECO:0000256|HAMAP-Rule:MF_00571}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|HAMAP-Rule:MF_00571}.
CC -!- SIMILARITY: Belongs to the galactose-1-phosphate uridylyltransferase
CC type 2 family. {ECO:0000256|ARBA:ARBA00008706, ECO:0000256|HAMAP-
CC Rule:MF_00571}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDG03422.1}.
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DR EMBL; CBLU010000002; CDG03422.1; -; Genomic_DNA.
DR RefSeq; WP_021721746.1; NZ_CBLU010000002.1.
DR AlphaFoldDB; S6FQX1; -.
DR UniPathway; UPA00214; -.
DR Proteomes; UP000015361; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008108; F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00571; GalP_UDP_trans; 1.
DR InterPro; IPR000766; GalP_uridyl_Trfase_II.
DR InterPro; IPR023425; GalP_uridyl_Trfase_II_CS.
DR InterPro; IPR005850; GalP_Utransf_C.
DR InterPro; IPR005849; GalP_Utransf_N.
DR NCBIfam; TIGR01239; galT_2; 1.
DR PANTHER; PTHR39191:SF1; DUF4922 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR39191; GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; 1.
DR Pfam; PF02744; GalP_UDP_tr_C; 1.
DR Pfam; PF01087; GalP_UDP_transf; 1.
DR PIRSF; PIRSF006005; GalT_BS; 1.
DR PROSITE; PS01163; GAL_P_UDP_TRANSF_II; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277, ECO:0000256|HAMAP-
KW Rule:MF_00571};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00571};
KW Galactose metabolism {ECO:0000256|ARBA:ARBA00023144, ECO:0000256|HAMAP-
KW Rule:MF_00571};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695, ECO:0000256|HAMAP-
KW Rule:MF_00571};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW Rule:MF_00571}.
FT DOMAIN 19..228
FT /note="Galactose-1-phosphate uridyl transferase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01087"
FT DOMAIN 244..438
FT /note="Galactose-1-phosphate uridyl transferase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02744"
SQ SEQUENCE 493 AA; 56648 MW; 42647D2733DA9FEB CRC64;
MSIYQSIQDF ISLALQNGTI EPLDELYHRN QLLHFLGLND WAEVDKESHE KDSLILMDQL
LAIANENNVI EKGQDEFYEA ALMNFITPRP SKINHDFWEK YKISPDAATQ YFYELAQQVN
QVKTRDIARN IAFSHLTKYG KLEITINLSK PEKDPKAIAA AKLVKASSYP ACQLCLENEG
FYGIGNKPAR SNHRIIQVSI NGEDWGFQYS PYAYFNEHSI LLNAKHQPME INKRAFDNLL
GFLDQFPDYM IGSNADLPIV GGSILTHDHY QAGRYEFPME KAELREEIKL QQFPEVSCGI
VNWPMSVLRL SSKNQVELSK AADELLKKWQ VYSDESLQIK AKSADGKLHH TITPIARIRE
GKYELDLVLR DNNTSEIYPD GIFHPHPALH HIKKENIGLI EVMGLAILPA RLKTELLEVE
KYLLNQENEM SEIHRPWAEE LKETEYFSKE TVHETVQEAV GEVFEQVLKD AGVFKDNEVG
QKGFYEFINF VNN
//
