ID S6GCM2_9GAMM Unreviewed; 440 AA.
AC S6GCM2;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=HemY N-terminal domain-containing protein {ECO:0000259|Pfam:PF07219};
GN ORFNames=OFPII_38090 {ECO:0000313|EMBL:EPJ44010.1};
OS Osedax symbiont Rs1.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Oceanospirillaceae.
OX NCBI_TaxID=1330036 {ECO:0000313|EMBL:EPJ44010.1, ECO:0000313|Proteomes:UP000014822};
RN [1] {ECO:0000313|EMBL:EPJ44010.1, ECO:0000313|Proteomes:UP000014822}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Rs1 {ECO:0000313|Proteomes:UP000014822};
RA Yi H., Goffredi S.;
RT "Comparative genomics of two novel heterotrophic symbionts of deep-sea
RT Osedax worms: functional variation and environmental selection.";
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in a late step of protoheme IX synthesis.
CC {ECO:0000256|ARBA:ARBA00002962}.
CC -!- PATHWAY: Porphyrin-containing compound metabolism; protoheme
CC biosynthesis. {ECO:0000256|ARBA:ARBA00004744}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPJ44010.1}.
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DR EMBL; ASZJ01000180; EPJ44010.1; -; Genomic_DNA.
DR AlphaFoldDB; S6GCM2; -.
DR UniPathway; UPA00252; -.
DR Proteomes; UP000014822; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042168; P:heme metabolic process; IEA:InterPro.
DR GO; GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR005254; Heme_biosyn_assoc_TPR_pro.
DR InterPro; IPR010817; HemY_N.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR NCBIfam; TIGR00540; TPR_hemY_coli; 1.
DR Pfam; PF07219; HemY_N; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50005; TPR; 1.
PE 4: Predicted;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244};
KW Reference proteome {ECO:0000313|Proteomes:UP000014822};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 43..68
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 27..133
FT /note="HemY N-terminal"
FT /evidence="ECO:0000259|Pfam:PF07219"
FT REPEAT 370..403
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 400..440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 440 AA; 48933 MW; CBA606CBABD9BF12 CRC64;
MKRVLILLFI VLAAGAFIGE KMVQDPGYVL LAFNNTTIET SVWVLLLLTF FGFLITHWTV
NLFFRIGIPG QFIGRWRKAR IASSAQKRTF KGLIALSEGQ WWQAQRLLSQ TAPIAAQPLI
NYLGAAKAAH EQGNTADTDE FFARARAIAP AAEVSISLQE VDVLMDRGNS AQALITLKRL
HSLAPKHTGI LRHLAELHQN QQDWDGLIAL MSKLRKHKVF TIEQLAAMET NCYRQMLSTV
VKKLPVECST DVRVKALTKG WKALPNTLNQ TAAMKATYAS ALNAANAPDD AEKFLRTQIK
RDWDNQLIGL YGTLQTSDPT KHYNTVAGWL KKQPTHAALE LCAARLAMFN EKWQIAVQHY
QSSIDLQPKV EAYRGLARLL ESLGEHEKSL EMNQKAMDLT EDDSPLIPLP APLETPAEET
AKTAESTAIK VEKKPTTASA
//
