ID S6HQP6_9GAMM Unreviewed; 793 AA.
AC S6HQP6;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=endopeptidase La {ECO:0000256|PROSITE-ProRule:PRU01122};
DE EC=3.4.21.53 {ECO:0000256|PROSITE-ProRule:PRU01122};
GN ORFNames=OFPII_12970 {ECO:0000313|EMBL:EPJ47410.1};
OS Osedax symbiont Rs1.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Oceanospirillaceae.
OX NCBI_TaxID=1330036 {ECO:0000313|EMBL:EPJ47410.1, ECO:0000313|Proteomes:UP000014822};
RN [1] {ECO:0000313|EMBL:EPJ47410.1, ECO:0000313|Proteomes:UP000014822}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Rs1 {ECO:0000313|Proteomes:UP000014822};
RA Yi H., Goffredi S.;
RT "Comparative genomics of two novel heterotrophic symbionts of deep-sea
RT Osedax worms: functional variation and environmental selection.";
RL Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of proteins in presence of ATP.; EC=3.4.21.53;
CC Evidence={ECO:0000256|PROSITE-ProRule:PRU01122};
CC -!- SIMILARITY: Belongs to the peptidase S16 family. {ECO:0000256|PROSITE-
CC ProRule:PRU01122}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPJ47410.1}.
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DR EMBL; ASZJ01000066; EPJ47410.1; -; Genomic_DNA.
DR AlphaFoldDB; S6HQP6; -.
DR PATRIC; fig|1330036.3.peg.1233; -.
DR Proteomes; UP000014822; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004176; F:ATP-dependent peptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030163; P:protein catabolic process; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR041699; AAA_32.
DR InterPro; IPR046844; Lon-like_helical.
DR InterPro; IPR008269; Lon_proteolytic.
DR InterPro; IPR027065; Lon_Prtase.
DR InterPro; IPR046843; LonB_AAA-LID.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR PANTHER; PTHR10046; ATP DEPENDENT LON PROTEASE FAMILY MEMBER; 1.
DR PANTHER; PTHR10046:SF49; LON PROTEASE HOMOLOG-RELATED; 1.
DR Pfam; PF13654; AAA_32; 1.
DR Pfam; PF05362; Lon_C; 1.
DR Pfam; PF20436; LonB_AAA-LID; 1.
DR Pfam; PF20437; LonC_helical; 1.
DR PRINTS; PR00830; ENDOLAPTASE.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS51786; LON_PROTEOLYTIC; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU01122};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01122}; Reference proteome {ECO:0000313|Proteomes:UP000014822};
KW Serine protease {ECO:0000256|PROSITE-ProRule:PRU01122}.
FT DOMAIN 560..756
FT /note="Lon proteolytic"
FT /evidence="ECO:0000259|PROSITE:PS51786"
FT ACT_SITE 650
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01122"
FT ACT_SITE 693
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01122"
SQ SEQUENCE 793 AA; 87345 MW; 90F09318B9AB38E9 CRC64;
MSLTPLTAEQ LYKKCDPNLF DFTDTSTVKK FDGCFGQNRA LQAMTFGVGM RRPGYNFFVM
GNPHTGRSSF TMDMLNSVAS QEVTPSDWIY INNFEDGRSA IAISLPAGRA AKLKADHQIL
LEAISTELPG AFESPDFQRK KSQIEKQFNA LYDTALDDVE QSARGLSVAM YRDAGNLGFA
PVSDGKVLDE AEFLLLDEKI RQSINQNIAD LEDLLSESLT ALPVWRREAA EQMKHLEKTT
TIKAVQPLLA KLQKAYKKHP KLTAYYLKML VHLADHTEDF LNDEKSGELL TDTVRRALLQ
EWYSINLFVD NSNTKGTPVI YDPHPIYENL FGRVEVANDL SVLATSYLRI RSGTLHKANG
GYLVIDAEKL LEMPQVYAAL KRALKAQEVR IEAPSDVAGS AISQTPLPVD LQVKVALVGA
RSTYYLLQDF DADFEKTFRV VVDFDEVVPR TADSIRSYAR LIKTLAAQEG LAAFTRDAVV
RLIEHSSRSA DDTSMLSSHI GDIVDLLCEA DYKRNQAGDS LVSSKHINLA LHAQQARTGR
LSERIIDNIV NEVILIDTQG EKVGKCNGLT ILQVGDTSFG TPARITATVY PGKQGILDIE
REAELGQSIH SKGILILSGY LGFKYAKGFA IQISANIAME QSYGTVDGDS ASLAEVCALI
SSLTKIPISQ SFAVTGSINQ YGEVQAIGGV NEKIEGFFEV CKKREFVGGP QGVIVPVANI
RNMMLKQEVI KAVERGHFFI YAVDSVDQCL SLLMGIAAGV LSTDDCYDQH SINAIAVDCF
KQLSMIKADR TTY
//
