ID S6TXD2_PSESF Unreviewed; 135 AA.
AC S6TXD2;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE RecName: Full=Ferric uptake regulation protein {ECO:0000256|ARBA:ARBA00020910, ECO:0000256|RuleBase:RU364037};
GN Name=fur {ECO:0000256|RuleBase:RU364037};
GN ORFNames=A244_23520 {ECO:0000313|EMBL:EPN46662.1};
OS Pseudomonas syringae pv. actinidiae ICMP 18807.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas; Pseudomonas syringae.
OX NCBI_TaxID=1194404 {ECO:0000313|EMBL:EPN46662.1, ECO:0000313|Proteomes:UP000015729};
RN [1] {ECO:0000313|EMBL:EPN46662.1, ECO:0000313|Proteomes:UP000015729}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ICMP 18807 {ECO:0000313|EMBL:EPN46662.1,
RC ECO:0000313|Proteomes:UP000015729};
RX PubMed=23935484; DOI=10.1371/journal.ppat.1003503;
RA McCann H.C., Rikkerink E.H., Bertels F., Fiers M., Lu A., Rees-George J.,
RA Andersen M.T., Gleave A.P., Haubold B., Wohlers M.W., Guttman D.S.,
RA Wang P.W., Straub C., Vanneste J.L., Rainey P.B., Templeton M.D.;
RT "Genomic analysis of the Kiwifruit pathogen Pseudomonas syringae pv.
RT actinidiae provides insight into the origins of an emergent plant
RT disease.";
RL PLoS Pathog. 9:E1003503-E1003503(2013).
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|PIRSR:PIRSR602481-2};
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|PIRSR:PIRSR602481-2};
CC Note=Binds 1 Mn(2+) or Fe(2+) ion per subunit.
CC {ECO:0000256|PIRSR:PIRSR602481-2};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738,
CC ECO:0000256|RuleBase:RU364037}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU364037}.
CC -!- SIMILARITY: Belongs to the Fur family. {ECO:0000256|ARBA:ARBA00007957,
CC ECO:0000256|RuleBase:RU364037}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPN46662.1}.
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DR EMBL; AOKG01001631; EPN46662.1; -; Genomic_DNA.
DR RefSeq; WP_002555142.1; NZ_ANJL01000018.1.
DR AlphaFoldDB; S6TXD2; -.
DR GeneID; 73737136; -.
DR PATRIC; fig|1194404.4.peg.4843; -.
DR Proteomes; UP000015729; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd07153; Fur_like; 1.
DR Gene3D; 3.30.1490.190; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR002481; FUR.
DR InterPro; IPR043135; Fur_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR33202:SF2; FERRIC UPTAKE REGULATION PROTEIN; 1.
DR PANTHER; PTHR33202; ZINC UPTAKE REGULATION PROTEIN; 1.
DR Pfam; PF01475; FUR; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|RuleBase:RU364037};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU364037};
KW Iron {ECO:0000256|PIRSR:PIRSR602481-2, ECO:0000256|RuleBase:RU364037};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR602481-2,
KW ECO:0000256|RuleBase:RU364037}; Repressor {ECO:0000256|RuleBase:RU364037};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364037};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364037};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU364037}.
FT BINDING 86
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR602481-2"
FT BINDING 88
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR602481-2"
FT BINDING 107
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR602481-2"
FT BINDING 124
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR602481-2"
SQ SEQUENCE 135 AA; 15242 MW; A6BA17AA7CF0BCE1 CRC64;
MVENSELRKA GLKVTLPRVK ILQMLDSAEQ RHMSAEDVYK ALMEASEDVG LATVYRVLTQ
FEAAGLVVRH NFDGGHAVFE LADGGHHDHM VNVESGEVIE FFDEEIEKLQ KAIVERHGFD
LVDHNLVLYV RNKKA
//
