ID S7HVA9_VIBFL Unreviewed; 1153 AA.
AC S7HVA9;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969};
GN ORFNames=L910_2835 {ECO:0000313|EMBL:EPP19608.1};
OS Vibrio fluvialis PG41.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=1336752 {ECO:0000313|EMBL:EPP19608.1, ECO:0000313|Proteomes:UP000014854};
RN [1] {ECO:0000313|EMBL:EPP19608.1, ECO:0000313|Proteomes:UP000014854}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PG41 {ECO:0000313|EMBL:EPP19608.1,
RC ECO:0000313|Proteomes:UP000014854};
RX PubMed=23895343; DOI=10.1186/1757-4749-5-20;
RA Khatri I., Mahajan S., Dureja C., Subramanian S., Raychaudhuri S.;
RT "Evidence of a new metabolic capacity in an emerging diarrheal pathogen:
RT lessons from the draft genomes of Vibrio fluvialis strains PG41 and
RT I21563.";
RL Gut Pathog. 5:20-20(2013).
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPP19608.1}.
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DR EMBL; ASXS01000029; EPP19608.1; -; Genomic_DNA.
DR RefSeq; WP_020332321.1; NZ_ASXS01000029.1.
DR AlphaFoldDB; S7HVA9; -.
DR PATRIC; fig|1336752.4.peg.4511; -.
DR Proteomes; UP000014854; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.11180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}.
FT DOMAIN 620..780
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 797..954
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1153 AA; 129970 MW; 9AC972BF4098DF6E CRC64;
MSNTGCSELK NIQNVCKKGI GGLCGSSVSL AISEIFSDLV KSSIIVCKDN NEASEILSQL
RFFSAVNEDQ IIHIPEIEVL PYDTESPNAS VSALRISAFN KLASMNGDKR LVVTTAAAAT
QYIMDFDYWI NTQINLKVNE QVSIQQVEEK LIAVGYEKAN LEVTKPGEFT VINNILDIYP
LSHDKPARIA VSDSDHITSI KTFDSITQKS IATLESIQIL QAREVPLDKP SSILFRKNFR
KEFSSATGDV TYSQISAGET PEGIEFYTYL YDQHTTLMEK LSERQFNVFL TSGFSSHYSQ
VISTAKERYE ELKDDKKRKI LPPQKVWLNS ESLINCISRT NSIFLSEDKK GFDTVYDTEN
TGFSKKHSLS DIMSMLSPYV KKAEKVVFVL HSEARSDQIV AISRLLRMKS LFAKKWDEAK
NAPEKAVIVY SNVNTGYFDN THKILVVTEK EIFGMPIQAK IEDESEVVDE DNNHQFIKDL
EIDDLVVHTH YGIGKYKGLK QLSLETDGNE YFTIEYQDSA LAFVQISDLH LVNKYNGLNP
ESVKIDRLDE KGSSWKDEIA KVVDDIEGTA LTLIEAQIQR EKMVGIQIPE PKADYYRFCR
EFPYQATNDQ LKAVEDIKND LVSARPMDRL VAGDVGFGKT EVALRASMIV ASAGAQVVLV
APSTILAQQH YRSFKARFES FGINVVELTS GTQKIEKEII QQIENGEAHI IIGTHKAIKR
AIDYHNLALV IIDEEHRFGV NDKENIRSRF SGINILAMTA TPIPRTLNMS LSGIKDTSTL
RQPPANRLNI RTIVSEFNDQ LIVEAIKREM LRNGQLFFLH NNTTSIYARA EYLKNLFPDL
RIGIAHGKMH ALEVEAVMSA FYKHEFDMLI ATTIIENGID VPNANTILIE NANAFGLAAL
HQLRGRVGRS TRQGYAYLLT SGNNITEEGM KRLNAMEKTS KIGEGYKLAN HDLEIRGAGE
ILGESQSGHI SKMGYSLYHF ILNKCIEILK SNNFESLSDF QLQSLKEGDE SINIDVGVKY
SIPENYIPHP NLRLYYYRRI SMAEKVSEVN DVFQEMEDRF GKSPYLVGNL IFITKLKMAA
KRLKIVGIHA NEDGGKIIFS RSVKDRDSIL NIFVKDPENM QISVVHGEKA MIHFNKKLPN
TKDRVGYIRQ ILL
//
