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Database: UniProt
Entry: S7MED6_MYOBR
LinkDB: S7MED6_MYOBR
Original site: S7MED6_MYOBR 
ID   S7MED6_MYOBR            Unreviewed;      1782 AA.
AC   S7MED6;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   07-JUN-2017, entry version 30.
DE   SubName: Full=Sodium leak channel non-selective protein {ECO:0000313|EMBL:EPQ02679.1};
GN   ORFNames=D623_10022583 {ECO:0000313|EMBL:EPQ02679.1};
OS   Myotis brandtii (Brandt's bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera;
OC   Vespertilionidae; Myotis.
OX   NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ02679.1, ECO:0000313|Proteomes:UP000052978};
RN   [1] {ECO:0000313|Proteomes:UP000052978}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23962925; DOI=10.1038/ncomms3212;
RA   Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA   Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D.,
RA   Hee Yim S., Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N.,
RA   Chen G., Kulakova O.I., Sun Y., Lee S.G., Bronson R.T., Moskalev A.A.,
RA   Sunyaev S.R., Zhang G., Krogh A., Wang J., Gladyshev V.N.;
RT   "Genome analysis reveals insights into physiology and longevity of the
RT   Brandt's bat Myotis brandtii.";
RL   Nat. Commun. 4:2212-2212(2013).
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DR   EMBL; KE161248; EPQ02679.1; -; Genomic_DNA.
DR   Proteomes; UP000052978; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005261; F:cation channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028823; NALCN.
DR   PANTHER; PTHR10037:SF252; PTHR10037:SF252; 1.
DR   Pfam; PF00520; Ion_trans; 4.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000052978};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000052978};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     85    105       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    111    132       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    152    171       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    183    202       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    222    239       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    343    366       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    429    447       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    467    490       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    550    572       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    619    643       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    925    949       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1000   1018       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1061   1084       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1178   1201       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1255   1275       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1281   1300       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1320   1338       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1380   1402       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1467   1491       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       80    375       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      428    647       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      931   1206       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1253   1501       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      842    871       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1782 AA;  205017 MW;  4CB67C7DBDC8FC79 CRC64;
     MENAQMTGTE SMSPEMGQEW GSVEGAQENQ KTAVLCSLTR ANSSMLKRKQ SSRVEAQPVT
     DFGPDESLSD NADILWINKP WVHSLLRICA IISVISVCMN TPMTFEHYPP LQYVTFTLDT
     LLMFLYTAEM IAKMHIRGIV KGDTAYLKDR WCVFDGVMVV FLWVSLVLQV FEIADIVDQM
     SPWGMLRIPR PLIMIRAFRI YFRFELPRTR ITNILKRSGE QIWSVSIFLL FFLLLYGILG
     VQMFGTFTYH CVVNDTRPGN VTWNSLAIPD THCSPELEEG YQCPPGFKCM DLEDLGLSRQ
     ELGYSGFNEI GTSIFTVYEA ASQEGWVFLM YRAIDSFPRW RSYFYFITLI FFLAWLVKNV
     FIAVIIETFA EIRVQFQQMW GSRSSTTSTA TTQMFHEDAA GGWQLVAVDV NKPQGRAPAC
     LQQMMRSSVF HMFILSMVTV DVIVAASNYH KGESFRRQYD EFYLAEVAFT VLFDLEALLK
     IWCLGFTGYI SSSLHKFELL LVIGTTLHVY PDLYHSQFTY FQVLRVVRLI KISPALEDFV
     YKIFGPGKKL GSLVVFTASL LIVMSAISLQ MFCFVEELDR FTTFPRAFMS MFQILTQEGW
     VDVMDQTLNA VGHMWAPVVA IYFILYHLFA TLILLSLFVA VILDNLELDE DLKKLKQLKQ
     SEANADTKEK LPLRLRIFEK FPNRPQMVKI SKLPSDFTVP KIRESFMKQF IDRQQQDTCC
     LLRSLPSASS SSCDHSKRSA IEDNKYIDQK LRKSVFSIRA RNLLEKETAV TKILRACTRQ
     RMLSGSFEGQ PAKERSILSV QHHIRQERRS LRHGSNSQRI SRGKSLETLT QDHSNTVRYR
     NAQREDSEIK MIQEKKEQAE MKRKVQEEEL RENHPYFDKP LFIVGREHRF RNFCRVVVRA
     RFNASKTDPV TGAVKNTKYH QLYDLLGLVT YLDWVMIIVT ICSCISMMFE SPFRRVMHAP
     TLQIAEYVFV IFMSIELNLK IMADGLFFTP TAVIRDFGGV MDIFIYLVSL IFLCWMPQNV
     PAESGAQLLM VLRCLRPLRI FKLVPQMRKV VRELFSGFKE IFLVSILLLT LMLVFASFGV
     QLFAGKLAKC NDPNIIRRED CNGIFRINVS VSKNLNLKLR PGEKKPGFWV PRVWANPRNF
     NFDNVGNAML ALFEVLSLKG WVEVRDVIIH RVGPMHGIYI HVFVFLGCMI GLTLFVGVVI
     ANFNENKGTA LLTVDQRRWE DLKSRLKIAQ PLHLPPRPDN DGFRAKMYDI TQHPFFKRTI
     ALLVLAQSVL LSVKWDVEDP VTVPLATMSV VFTFIFVLEV TMKIIAMSPA GFWQSRRNRY
     DLLVTSLGIV WVVLHFALLN AYTYMMGACV IVFRFFSICG KHVTLKMLLL TVVVSMYKSF
     FIIVGMFLLL LCYAFAGVVL FGTVKYGENI NRHANFSSAG KAITVLFRIV TGEDWNKIMH
     DCMVQPPFCT PDEFTYWATD CGNYAGALMY FCSFYVIIAY IMLNLLVAII VENFSLFYST
     EEDQLLSYND LRHFQIIWNM VDDKREGVIP TFRVKFLLRL LRGRLEVDLD KDKLLFKHMC
     YEMERLHNGG DVTFHDVLSM LSYRSVDIRK SLQLEELLAR EQLEYTIEEE VAKQTIRMWL
     KKCLKRIRAK QQQSCSIIHS LRESQQQELS RFLNPPSIET TQPSEDMNAN SQDNNMQPET
     SSQQQLLSPT LSDRGGSRQD AGDAGKPQRK FGQWRLPSAP KPISHSVSSV NLRFGGRTTM
     KSVVCKMNPM TDTASCGSEV KKWWTRQLTV ESDESGDDLL DI
//
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