ID S7MUD6_MYOBR Unreviewed; 2863 AA.
AC S7MUD6;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Adenomatous polyposis coli protein {ECO:0000313|EMBL:EPQ07924.1};
GN ORFNames=D623_10033156 {ECO:0000313|EMBL:EPQ07924.1};
OS Myotis brandtii (Brandt's bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ07924.1, ECO:0000313|Proteomes:UP000052978};
RN [1] {ECO:0000313|Proteomes:UP000052978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23962925; DOI=10.1038/ncomms3212;
RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA Krogh A., Wang J., Gladyshev V.N.;
RT "Genome analysis reveals insights into physiology and longevity of the
RT Brandt's bat Myotis brandtii.";
RL Nat. Commun. 4:2212-2212(2013).
CC -!- SIMILARITY: Belongs to the adenomatous polyposis coli (APC) family.
CC {ECO:0000256|ARBA:ARBA00009051}.
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DR EMBL; KE162363; EPQ07924.1; -; Genomic_DNA.
DR RefSeq; XP_014395385.1; XM_014539899.1.
DR RefSeq; XP_014395386.1; XM_014539900.1.
DR RefSeq; XP_014395387.1; XM_014539901.1.
DR GeneID; 102246124; -.
DR CTD; 324; -.
DR eggNOG; KOG2122; Eukaryota.
DR OrthoDB; 2963825at2759; -.
DR Proteomes; UP000052978; Unassembled WGS sequence.
DR GO; GO:0071944; C:cell periphery; IEA:UniProt.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0008013; F:beta-catenin binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.10; -; 1.
DR Gene3D; 1.10.287.450; Helix hairpin bin; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR009240; APC_15aa_rpt.
DR InterPro; IPR009234; APC_basic_dom.
DR InterPro; IPR026831; APC_dom.
DR InterPro; IPR026818; Apc_fam.
DR InterPro; IPR032038; APC_N.
DR InterPro; IPR036149; APC_N_sf.
DR InterPro; IPR041257; APC_rep.
DR InterPro; IPR009223; APC_rpt.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR009232; EB1-bd.
DR InterPro; IPR009224; SAMP.
DR PANTHER; PTHR12607:SF11; ADENOMATOUS POLYPOSIS COLI PROTEIN; 1.
DR PANTHER; PTHR12607; ADENOMATOUS POLYPOSIS COLI PROTEIN FAMILY; 1.
DR Pfam; PF05972; APC_15aa; 4.
DR Pfam; PF05956; APC_basic; 1.
DR Pfam; PF16689; APC_N_CC; 1.
DR Pfam; PF05923; APC_r; 7.
DR Pfam; PF18797; APC_rep; 1.
DR Pfam; PF16634; APC_u13; 1.
DR Pfam; PF16635; APC_u14; 1.
DR Pfam; PF16636; APC_u15; 1.
DR Pfam; PF16630; APC_u5; 1.
DR Pfam; PF16633; APC_u9; 1.
DR Pfam; PF00514; Arm; 3.
DR Pfam; PF16629; Arm_APC_u3; 1.
DR Pfam; PF05937; EB1_binding; 1.
DR Pfam; PF05924; SAMP; 3.
DR Pfam; PF11414; Suppressor_APC; 1.
DR SMART; SM00185; ARM; 7.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF58050; N-terminal coiled coil domain from apc; 1.
DR SUPFAM; SSF82931; Tumor suppressor gene product Apc; 1.
DR PROSITE; PS50176; ARM_REPEAT; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000052978};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT DOMAIN 4..55
FT /note="Adenomatous polyposis coli N-terminal dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16689"
FT REPEAT 678..720
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT DOMAIN 2245..2596
FT /note="Adenomatous polyposis coli protein basic"
FT /evidence="ECO:0000259|Pfam:PF05956"
FT DOMAIN 2691..2863
FT /note="EB-1 binding"
FT /evidence="ECO:0000259|Pfam:PF05937"
FT REGION 239..306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 793..812
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 846..898
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 914..962
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 977..1009
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1077..1098
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1118..1186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1199..1268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1343..1393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1420..1491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1544..1628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1693..1871
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1897..1972
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1985..2032
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2064..2089
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2171..2653
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2686..2736
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2753..2863
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 6..54
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 134..168
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 258..304
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 860..875
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 883..898
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 918..933
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 944..962
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 977..993
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1119..1149
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1150..1186
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1201..1268
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1343..1359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1374..1391
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1450..1465
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1563..1581
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1699..1719
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1768..1799
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1806..1851
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1897..1912
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1913..1958
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2191..2212
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2221..2246
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2255..2270
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2279..2447
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2482..2528
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2540..2554
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2578..2601
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2602..2617
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2638..2653
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2690..2729
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2753..2833
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2843..2863
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2863 AA; 313921 MW; 04A45AAD1F0577D1 CRC64;
MAAASYDQLL KQVEALKMEN SNLRQELEDN SNHLTKLETE ASNMKEVLKQ LQGSIEDEAM
TSSGQIDLLE RLKELNLDSS NFPGVKLRSK MSLRSYGSRE GSVSSRSGEC SPVPMGSFPR
RGFVNGSREN TGYLEELEKE RSLLLADLDK EEKEKDWYYA QLQNLTKRID SLPLTENFSL
QTDMTRRQLE YEARQIRVAM EEQLGTCQDM EKRAQRRVTR IQQIEKDILR IRQLLQSQAT
EAERSSQSKH EAGSHEAEQQ NEGQGVAEIN MATSGSGQSS ATRMDHETAS VLSSSSTHSA
PRRLTSHLGT KVEMVYSLLS MLGTHDKDDM SRTLLAMSSS QDSCISMRQS GCLPLLIQLL
HGNDKDSVLL GNSRGSKEAR ARASAALHNI IHSQPDDKRG RREIRVLHLL EQIRAYCETC
WEWQEAHEQG MDQDKNPMPA PVEHQICPAV CVLMKLSFDE EHRHAMNELG RKATRGISSQ
ELGQGLSGGL QAIAELLQVD CEMYGLTNDH YSITLRRYAG MALTNLTFGD VANKATLCSM
KGCMRALVAQ LKSESEDLQQ VIASVLRNLS WRADVNSKKT LREVGSVKAL MECALEVKKE
STLKSVLSAL WNLSAHCTEN KADICAVDGA LAFLVGTLTY RSQTNTLAII ESGGGILRNV
SSLIATNEDH RQILRENNCL QTLLQHLKSH SLTIVSNACG TLWNLSARNP KDQEALWDMG
AVSMLKNLIH SKHKMIAMGS AAALRNLMAN RPAKYKDANI MSPGSSLPSL HVRKQKALEA
ELDAQHLSET FDNIDNLSPK TSHRSKQRHK QSLYGDYVFD TNRHDDNRSD NFNTGNMTVL
SPYLNTTVLP SSSSSRGSLD SSRSEKDRSL ERERGITLGN YHPATENPGT SSKRSLQIST
TAAQIAKVME EVSAIHTSQE DRSSGSTTEL HCGTDERNAL RRSSTAHTHS NTYNFTKSEN
SNRTCPIPYA KLEYKRSSND SLNSVSSSDG YGKRGQMKPS IESYSEDDES KCCSYGQYPA
DLAHKIHSAN HMDDNDGELD TPINYSLKYS DEQLNSGRQS PSQNERWARP KHIIEDEMKH
SEQRQSRSQS TTYPVYTEST DDKHLKFQPH FGQQECVSPY RSRGASASET NRVGSNHGIN
QNVNQSLCQE NDYEDDKPTN YSERYSEEEQ HEEEERPTNY SIKYNEEKHV EQPIDYSLKY
STDIPPSQKP SFSFSKSSSG QSTKTEHIST SSENTSTPSS NAKRQNQLHP SSAQSRSGQT
QKATSCKVPS INQETIQTYC VEDTPICFSR CSSLSSLSSA EDEMGCDQRT QETDSANTLQ
IAEIKENSGT RATEVSVNEV PTVSQHIRTK NNRLPASGLS SESARHKAVE LSSGAKSPSK
SGAQTPKSPP EHYVQETPLM FSRCTSVSSL DSFESRSIAS SVQSEPCSGM VSGIISPSDL
PDSPGQTMPP SRSKTPPPPP LPQTVQAKQE VPKNKVPNAE KRESGPKQAA VNAAVQRVQV
LPDADTLLHF ATESTPDGFS CSSSLSALSL DEPFIQKDVE LRIMPPVQEN DNVNETESEQ
PEESNENLEK EAEKPTDSEK DILDDSDDDD IEILEECIIS AMPTKSSHKA KKPAQSASKL
PPPVARKPSQ LPVYKLLPSQ NRIQAQKHVS FTPGDDMPRV YCVEGTPINF STATSLSDLT
IESPPNELTA VEGVRAGAQT GEFEKRDTIP TEGRSTDEAQ RGKTSSVTIP ELDDSKTEEG
DILAECINSA MPKGKSHKPF RVKKIMDQVQ QASMSSSGNN KNQLDGQKKK PTSPVKPMPQ
NTEYRAHVKK NTDSKNNLNA ERTFSDNKDS KKQNLKNNSK DFNDKLPNNE DRVRGSFTFD
SPHHYTPIEG TPYCFSRNDS LSSLDFDDDD VDLSREKAEL RKGKDNKESE AKVNSQTELT
MSQQSGNKTQ TVTKHPINRG QSNKPMLHKQ STFPQSSKDL PDRGAAADEK LQNFAIENTP
VCFSRNSSLS SLSDIDQENN NNKENEPIKE TVPPASQGEP SKPQASGYAP KSFHVEDTPV
CFSRNSSLSS LSIDSEDDLL QECISSAMPK KKKPSRLKGD NEKHSPRNMG GILAEDLTLD
LKDIQRPDSE HGLSPDSENF DWKAIQEGAN SIVSSLHQAA AAACLSRQAS SDSDSILSLK
SGISLGSPFH LTPDQEEKPF TCNKGPRILK PGEKSTLEAK KVESENKGIK GGKKVYKSLL
TGKVRSNSEI SSQLKQPLQA NMPSISRGRT MIHIPGVRNS SSSTSPVSKK GPPFKTPASK
SPSEGQTATT SPRGAKPSVK SELSPITRQT SQLAGSNKGP SRSGSRDSTP SRPAQQPLSR
PMQSPGRNSI SPGRNGISPP NKLSQLPRTS SPSTASTKSS GSGKMSYTSP GRQTSQQNLT
KQTGLSKNGS SIPRSESASK GLNQMNNSNG SNKKVELSRM SSTKSSGSES DRSERPVLVR
QSTFIKEAPS PTLRRKLEES ASFESLSPSS RPDSPTRSQA QTPVLSPSLP DMSLSTHTSV
QSGGWRKLPP NLSPTVEYND GRPAKRHDIA RSHSESPSRL PINRSGTWKR EHSKHSSSLP
RVSTWRRTGS SSSILSASSE SSEKAKSEDE KHVNCISGTK QTKENQVSTK GTWRKIKESE
ISPTNCTSHI ASSGAANGAE SKTLIYQMAP AVSKTEDVWV RIEDCPINNP RSGRSPTGNT
PPVINSVSEK GNPNAKDSKD NQGKPNVGNG SGPIRTMGLE NCLNSFIQVN APDQKGTEAK
PGQSNPVPAA ETNESSIAER TPFGSSSSSK HSSPSGTVAA RVTPFNYNPS PRKSSADSTS
ARPSQIPTPV NNSKKRDSKT DNTESSGTQS PKRHSGSYLV TSV
//
