ID S7N1T7_MYOBR Unreviewed; 1621 AA.
AC S7N1T7;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE SubName: Full=Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein {ECO:0000313|EMBL:EPQ10936.1};
DE Flags: Fragment;
GN ORFNames=D623_10004705 {ECO:0000313|EMBL:EPQ10936.1};
OS Myotis brandtii (Brandt's bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ10936.1, ECO:0000313|Proteomes:UP000052978};
RN [1] {ECO:0000313|Proteomes:UP000052978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23962925; DOI=10.1038/ncomms3212;
RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA Krogh A., Wang J., Gladyshev V.N.;
RT "Genome analysis reveals insights into physiology and longevity of the
RT Brandt's bat Myotis brandtii.";
RL Nat. Commun. 4:2212-2212(2013).
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DR EMBL; KE163123; EPQ10936.1; -; Genomic_DNA.
DR eggNOG; KOG3519; Eukaryota.
DR Proteomes; UP000052978; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd04440; DEP_2_P-Rex; 1.
DR CDD; cd00136; PDZ; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01224; PH_Collybistin_ASEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 2.30.42.10; -; 2.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22829; DEP DOMAIN PROTEIN; 1.
DR PANTHER; PTHR22829:SF6; PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE-DEPENDENT RAC EXCHANGER 1 PROTEIN; 1.
DR Pfam; PF00610; DEP; 2.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF00621; RhoGEF; 2.
DR SMART; SM00049; DEP; 2.
DR SMART; SM00228; PDZ; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 2.
DR SUPFAM; SSF50156; PDZ domain-like; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS50186; DEP; 2.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000052978}.
FT DOMAIN 1..202
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 233..354
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 383..458
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 491..559
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 587..634
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 757..783
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1072..1092
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EPQ10936.1"
SQ SEQUENCE 1621 AA; 183227 MW; 07AC0061090594A6 CRC64;
AFLHRIRQNV VDSAEKGLTE DNIKILFSNI EDILEVHKDF LAALEYCLHP EPQSQHELGN
VFLRFKDKFC VYEEYCSNHE KALRLLVELN KIPTVRAFLL KDKFCVYEEY CSNHEKALRL
LVELNKIPTV RAFLLSCMLL GGRKTTDIPL EGYLLSPIQR ICKYPLLLKE LAKRTPGKHP
DHPAVQSALQ AMKTVCSNIN ETKRQMEKLE ALEQLQSHIE GWEGSNLTDI CTQLLLQGTL
LKISAGNIQE RAFFLFDNLL VYCKRKSRVT GSKKSTKRTK SINGSLYIFR GRINTEVMEV
ENVEDGTADY HSHGYTVTNG WKIHNTAKNK WFVCMAKTAE EKQKWLDAII REREQRESLK
LGMERDAYVM IAEKGEKLYH MMMNKKVNLI KDRRRKLSTV PKCFLGNEFV AWLLEIGEIS
KTEEGVNLGQ ALLENGIIHH VSDKHQFKNE QVMYRFRYDD GTYKARSELE DIMSKGVRLY
CRLHSLYTPV IKDRDYHLKT YKSVLPGSKL VDWLLAQGDC QTREEAVALG VGLCNNGFMH
HVLEKSEFKD ESQYFRFHAD EEMEGTSSKN KQLRNDFKLV ENILAKRLLI LPQEEDYGFD
IEEKNKAVVV KSVQRGSLAE MAGLQVGRKI YSINEDLVFL RPFSEVESIL NQSFCSRRPV
RLLVATKAKE IVKVPDHPEA LCFQIRGAAP PYVYAVGRGS EAAAAGLCAG QCILKVNGNN
VMNDGAPEVL EHFQAFRNRR EEALGLYQWI YHTHEDAQEA RASQETPGED PGGEGAREED
QPDSAFPLLS MGAQLSLHED SPVVSLNVDN VHLEHGVVYE YVSTAGIKCH VLEKIVEPRG
CFGLTAKILE AFAADDSVFV QNCGRLMALS NSIRTMSHFE FRHICDIKLE SIGQRIACYQ
EFAAQLKSRI SPPFKQAPLE PHSPCGLDFC PTNCHINIME VSYPKTTPSI GRSFSIRFGR
KPSLIGLDPE QGHLNPMSYT QHCITTMAAP SWKCLPAVDG DPQCQSPRDS SFGPANGALG
PEDRGLSFLL KQEDREIQDA YLQLFTKLDV ALKEMKQYVT QINRLLSTIT EPTSGGSCHP
PLAEETSSSP LVNEESEMDR TDHGGIKKVC FKVSEEDQED SGHDTMSYRD SYSECNSNRD
SVLSYTSVRS NSSYLGSDEM GSGDELPCDM RIPSDKQDKL HGCLEHLFNQ VDSIHALLKG
PVMSRAFEET KHFPMDHCLQ EFKQKEECTI RGRSLIQISI QEDPWNLPNS IKTLVDNIQK
YVEDGKNQLL LALLKCTDTE LQLRRDTIFC QALVAAVCTF SEQLLAALSY RYNNNGEYEE
SSRDASRKWL EQVAATGVLL HCQSLLSPAT VKEERTMLED LWVTLSELDN VSFSFKQLDE
NYVANTNVFY HIEGSRQALK VIFYLDSYHF SKLPSRLESG GSLRLHTVLF TKALENPEGP
PPPGSQVVED LQQEINTQSL EKVQQYYRKL RAFYLERSNL PTDASTTAVK IDQLIRPINA
LDELCRLMKS FVHPKPGATG SLGASLIPVS SELCYRLGAC QIAMCGTGMQ RSTLSVSLEQ
AAILARSHGL LPKCIMQATD IMRKQGPRVE ILAKNLRVKD QMPQGAPRLY RLCQPPVDGD
L
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