ID S7N3S0_MYOBR Unreviewed; 803 AA.
AC S7N3S0;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Proprotein convertase subtilisin/kexin type 6 {ECO:0000313|EMBL:EPQ10680.1};
GN ORFNames=D623_10011759 {ECO:0000313|EMBL:EPQ10680.1};
OS Myotis brandtii (Brandt's bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ10680.1, ECO:0000313|Proteomes:UP000052978};
RN [1] {ECO:0000313|Proteomes:UP000052978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23962925; DOI=10.1038/ncomms3212;
RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA Krogh A., Wang J., Gladyshev V.N.;
RT "Genome analysis reveals insights into physiology and longevity of the
RT Brandt's bat Myotis brandtii.";
RL Nat. Commun. 4:2212-2212(2013).
CC -!- SIMILARITY: Belongs to the peptidase S8 family. {ECO:0000256|PROSITE-
CC ProRule:PRU01240}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01240}.
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DR EMBL; KE163054; EPQ10680.1; -; Genomic_DNA.
DR AlphaFoldDB; S7N3S0; -.
DR eggNOG; KOG1644; Eukaryota.
DR eggNOG; KOG3525; Eukaryota.
DR Proteomes; UP000052978; Unassembled WGS sequence.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00064; FU; 3.
DR CDD; cd04059; Peptidases_S8_Protein_convertases_Kexins_Furin-like; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.30.70.850; Peptidase S8, pro-domain; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR034182; Kexin/furin.
DR InterPro; IPR002884; P_dom.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR InterPro; IPR032815; S8_pro-domain.
DR InterPro; IPR038466; S8_pro-domain_sf.
DR PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR PANTHER; PTHR42884:SF8; PROPROTEIN CONVERTASE SUBTILISIN_KEXIN TYPE 6; 1.
DR Pfam; PF01483; P_proprotein; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR Pfam; PF16470; S8_pro-domain; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SMART; SM00261; FU; 3.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF54897; Protease propeptides/inhibitors; 1.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51829; P_HOMO_B; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00136; SUBTILASE_ASP; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000052978};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825}.
FT DOMAIN 362..512
FT /note="P/Homo B"
FT /evidence="ECO:0000259|PROSITE:PS51829"
SQ SEQUENCE 803 AA; 88723 MW; AAD701C63FEC77F3 CRC64;
MTCADHQGAA RNMVVSATRQ WQRAAVEIGN LENYYHFYHS KTFKRSTLSS RGPHTFLRMD
PQVKWLQQQE VKRRVKRLVR SEPQSLYFND PIWPNMWYLH CGDKQSRCRS EMNVQAAWKR
GYTGKNVVVT ILDDGIERNH PDLAPNYDSY ASYDVNGNDY DPSPRYDASN ENKHGTRCAG
EVAAAANNSY CIVGIAYNAK IGGIRMLDGD VTDVVEAKSL GVRPNYIDIY SASWGPDDDG
KTVDGPGRLA KQAFEYGIKK GRQGLGSIFV WASGNGGREG DYCSCDGYTN SIYTVSVSST
TENGYKPWYL EECPSTLATT YSSGAFYERK IVKGTYLGCS HLYGFGLVDA EALVLEAKKW
TAVPSQHTCV AFTDKRPRSI PVVQTLRTTA LTTACADHSD QRVGYLEHVV ARISISHPRR
GDLQIHLISP SGTKSQLLAK RVGKQPGASL PLHDHSNEGF SNWEFMTVHS WGEKAEGEWT
LEIQDMPSQV RSPGRQGKLK EWSLVLYGTA EHPYHTFRGV RTGAVPRPGA AITLLICTHT
ARSSQGPPSV SQTSLCHPEC GDKGCDGPGA DQCLSCVHFS LGNAKTGSPT QCLSCRRGFF
HHQETSTCVN PCPAGFYASD SQRKCLKCHP SCKKCVDDPE KCTVCKEGFS LARGSCIPDC
EPGTYFDSEL VRCGQCHPTC KTCVGPSREE CIHCASNLHF QDWKCVPACG EGYYPEAMPG
LPHRVCRRCH ENCRSCEVRR KLPELRGRPH QLGALWVANH TCSNGERGLG PGTAGQRPPL
PPNLTEPLFF LPSGQDFLLD GEV
//
