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Database: UniProt
Entry: S7NB10_MYOBR
LinkDB: S7NB10_MYOBR
Original site: S7NB10_MYOBR 
ID   S7NB10_MYOBR            Unreviewed;      1917 AA.
AC   S7NB10;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   24-JAN-2024, entry version 47.
DE   RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE            EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
GN   ORFNames=D623_10021805 {ECO:0000313|EMBL:EPQ13495.1};
OS   Myotis brandtii (Brandt's bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC   Myotis.
OX   NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ13495.1, ECO:0000313|Proteomes:UP000052978};
RN   [1] {ECO:0000313|Proteomes:UP000052978}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23962925; DOI=10.1038/ncomms3212;
RA   Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA   Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA   Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA   Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA   Krogh A., Wang J., Gladyshev V.N.;
RT   "Genome analysis reveals insights into physiology and longevity of the
RT   Brandt's bat Myotis brandtii.";
RL   Nat. Commun. 4:2212-2212(2013).
CC   -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC       subfamily. {ECO:0000256|ARBA:ARBA00006209}.
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DR   EMBL; KE163720; EPQ13495.1; -; Genomic_DNA.
DR   eggNOG; KOG0902; Eukaryota.
DR   Proteomes; UP000052978; Unassembled WGS sequence.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR   GO; GO:0048015; P:phosphatidylinositol-mediated signaling; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd00871; PI4Ka; 1.
DR   CDD; cd05167; PI4Kc_III_alpha; 1.
DR   Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR   Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR   InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR   InterPro; IPR018936; PI3/4_kinase_CS.
DR   InterPro; IPR001263; PI3K_accessory_dom.
DR   InterPro; IPR042236; PI3K_accessory_sf.
DR   InterPro; IPR045495; PI4K_N.
DR   InterPro; IPR015433; PI_Kinase.
DR   PANTHER; PTHR10048:SF15; PHOSPHATIDYLINOSITOL 4-KINASE ALPHA; 1.
DR   PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR   Pfam; PF00454; PI3_PI4_kinase; 1.
DR   Pfam; PF00613; PI3Ka; 1.
DR   Pfam; PF19274; PI4K_N; 4.
DR   SMART; SM00145; PI3Ka; 1.
DR   SMART; SM00146; PI3Kc; 1.
DR   SUPFAM; SSF48371; ARM repeat; 2.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR   PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR   PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR   PROSITE; PS51545; PIK_HELICAL; 1.
PE   3: Inferred from homology;
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EPQ13495.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000052978};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          1373..1561
FT                   /note="PIK helical"
FT                   /evidence="ECO:0000259|PROSITE:PS51545"
FT   DOMAIN          1651..1917
FT                   /note="PI3K/PI4K catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50290"
SQ   SEQUENCE   1917 AA;  215877 MW;  6AC0B2D6C6A6EFF8 CRC64;
     MCPVDFHGIF QLDERRRDAV IALGIFLIES DLQHKDSVVP YLLRLLKGLP KVYWVEESTA
     RKGRGVLPVA ESFSFCLVTL LSDVAYRDPS LRDEILEALL QVLHVLLGMC QALEIQEKEY
     LCKYAIPCLI GISRAFGRYS NTEESLLSKL FPKIPPHSLR VPEELEGVRR RSFNDFRSIL
     PSNLLTVCQE GTLKRKTSSV SSISQVSPER GMPPPSSPGG SAFHYFEVSY LPDGSALDPD
     YYFSTISSSF SVSPLFNGVT YKEFSVPLEM LRELLNLVKK IVEEPVLKSL DAVAASVLEA
     NPSADLYYTT FSDPLYVAMF KMLRDTLYYM KDLPTTFVKE IHDFVLEQFN TSQGELQKIL
     HDADRIHSEL SPLKLRCQAN AACVDLMVWA VKDEQGAESL CIKLSEKLQS KTSSKVIIAH
     LPLLICCLQG LGRLCERFPV VVHSVTPSLR DFLVVPSPVL VKLYKYHSQY HTVAGNDIKI
     SVTNEHSEST LNVMPGKKNQ PSMYEQLRDI AIDNICRCLK AGLTVDAVIV EAFLASLSNR
     LYISQESDKD AHLIPDHTIR ALGHIAVALR DTPKVMEPIL QILQQKFCQP PSPLDVLIID
     QLGCLVITGN QYIYQEVWNL FQQISVKASS VVYSATKDYK DHGYRHCSLA VINALANIAA
     NIQDEHLVDE LLMNLLELFV QLGLEGKRAS ERASEKGPAL KASSSAGNLG VLIPVIAVLT
     RRLPPIKEAK PRLQKLFRDF WLYSVLMGFA VEGSGLWPEE WYEGVCEIAT KSPLLTFPSK
     EPLRSVLQYN SAMKNDTVTP AELNELRSTI INLLDPAPEV SALINKLDFA MSTYLLSVYR
     LEYMRVLRST DPDRFQVMFC YFEDKAIQKD KSGMMQCVIA VADKVFEAFL NMMADKDIHK
     DQPYYSIPDA PYRITVPDTC EARESIVKDF AARCEMILQE AMKWAPTVTK SHLQEYLNKH
     QNWVSGLSQH TGLAMATESI LHFAGYNKQN TTLGATQLTE RPACVKKDYS NFMASLNLRN
     RYAGEVYGMI QFSDATGQIS DLNKMMVQEL NTALDLSNPQ PYTQAMFKLT AMLISSKDCD
     PQLLHHLCWG PLRMFNEHGM ETALACWEWL LAGKNGVEVP FLREMAGAWQ MTVEQKLGLF
     SAEIKEADPL AASEASQPKP CAPEVTPHCI WIDFLVQRFE IAKYCSSDQV EIFSSLLQRS
     MSLNIGGAKG SMNRHVAAIG PRFKLLTLGL SLLHADVVPN ATIRNVLREK IYSTAFDYFR
     RLILEATMSL PTDNQDTRSN LDIAVGSRQQ ATQGWINTYP LSSGMSTISK KSGMSKKTNR
     GSQLHKYYMK RRTLLLSLLA TEIERLTTWY NPLSAPELEL DQAGENSVAN WRSKYTSLSE
     KQWKDNVNLA WSISPYLAVQ LPARFKNTEA IGSEVTRLVR LDPGAVSDIP EAIKFLVTWH
     TIDADAPELS HVLCWAPADP PTGLSYFSSM YPPHPLTAQY GVKVLRSFPP DAILFYIPQI
     VQALRYDKMG YVREYILWAA SKSQLLAHQF IWNMKTNIYL DEEGHQKDPD IGDLLEQLVE
     EITGSLSGPA KDFYQREFDF FNKITNVSAI IKPYPKGDER KKACLAALSE VKVQPGCYLP
     SNPEAIVLDI DYKSGTPMQS AAKAPYLAKF KVKRCGVSEL EKEGLRCCSD AEDQGGTQEA
     DGQKISWQAA IFKVGDDCRQ DMLALQIIDL FKNIFQLVGL DLFVFPYRVV ATAPGCGVIE
     CIPDCTSRDQ LGRQTDFGMY DYFTRQYGDE STLAFQQARY NFIRSMAAYS LLLFLLQIKD
     RHNGNIMLDK KGHIIHIDFG FMFESSPGGN LGWEPDIKLT DEMVMIMGGK MEATPFKWFM
     EMCVRGYLAV RPYMDAVVSL VTLMLDTGLP CFRGQTIKLL KSRTYDMIQY YQNDIPY
//
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