ID S7NB10_MYOBR Unreviewed; 1917 AA.
AC S7NB10;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
GN ORFNames=D623_10021805 {ECO:0000313|EMBL:EPQ13495.1};
OS Myotis brandtii (Brandt's bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ13495.1, ECO:0000313|Proteomes:UP000052978};
RN [1] {ECO:0000313|Proteomes:UP000052978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23962925; DOI=10.1038/ncomms3212;
RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA Krogh A., Wang J., Gladyshev V.N.;
RT "Genome analysis reveals insights into physiology and longevity of the
RT Brandt's bat Myotis brandtii.";
RL Nat. Commun. 4:2212-2212(2013).
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
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DR EMBL; KE163720; EPQ13495.1; -; Genomic_DNA.
DR eggNOG; KOG0902; Eukaryota.
DR Proteomes; UP000052978; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0048015; P:phosphatidylinositol-mediated signaling; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00871; PI4Ka; 1.
DR CDD; cd05167; PI4Kc_III_alpha; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR045495; PI4K_N.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF15; PHOSPHATIDYLINOSITOL 4-KINASE ALPHA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR Pfam; PF19274; PI4K_N; 4.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EPQ13495.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000052978};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1373..1561
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 1651..1917
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
SQ SEQUENCE 1917 AA; 215877 MW; 6AC0B2D6C6A6EFF8 CRC64;
MCPVDFHGIF QLDERRRDAV IALGIFLIES DLQHKDSVVP YLLRLLKGLP KVYWVEESTA
RKGRGVLPVA ESFSFCLVTL LSDVAYRDPS LRDEILEALL QVLHVLLGMC QALEIQEKEY
LCKYAIPCLI GISRAFGRYS NTEESLLSKL FPKIPPHSLR VPEELEGVRR RSFNDFRSIL
PSNLLTVCQE GTLKRKTSSV SSISQVSPER GMPPPSSPGG SAFHYFEVSY LPDGSALDPD
YYFSTISSSF SVSPLFNGVT YKEFSVPLEM LRELLNLVKK IVEEPVLKSL DAVAASVLEA
NPSADLYYTT FSDPLYVAMF KMLRDTLYYM KDLPTTFVKE IHDFVLEQFN TSQGELQKIL
HDADRIHSEL SPLKLRCQAN AACVDLMVWA VKDEQGAESL CIKLSEKLQS KTSSKVIIAH
LPLLICCLQG LGRLCERFPV VVHSVTPSLR DFLVVPSPVL VKLYKYHSQY HTVAGNDIKI
SVTNEHSEST LNVMPGKKNQ PSMYEQLRDI AIDNICRCLK AGLTVDAVIV EAFLASLSNR
LYISQESDKD AHLIPDHTIR ALGHIAVALR DTPKVMEPIL QILQQKFCQP PSPLDVLIID
QLGCLVITGN QYIYQEVWNL FQQISVKASS VVYSATKDYK DHGYRHCSLA VINALANIAA
NIQDEHLVDE LLMNLLELFV QLGLEGKRAS ERASEKGPAL KASSSAGNLG VLIPVIAVLT
RRLPPIKEAK PRLQKLFRDF WLYSVLMGFA VEGSGLWPEE WYEGVCEIAT KSPLLTFPSK
EPLRSVLQYN SAMKNDTVTP AELNELRSTI INLLDPAPEV SALINKLDFA MSTYLLSVYR
LEYMRVLRST DPDRFQVMFC YFEDKAIQKD KSGMMQCVIA VADKVFEAFL NMMADKDIHK
DQPYYSIPDA PYRITVPDTC EARESIVKDF AARCEMILQE AMKWAPTVTK SHLQEYLNKH
QNWVSGLSQH TGLAMATESI LHFAGYNKQN TTLGATQLTE RPACVKKDYS NFMASLNLRN
RYAGEVYGMI QFSDATGQIS DLNKMMVQEL NTALDLSNPQ PYTQAMFKLT AMLISSKDCD
PQLLHHLCWG PLRMFNEHGM ETALACWEWL LAGKNGVEVP FLREMAGAWQ MTVEQKLGLF
SAEIKEADPL AASEASQPKP CAPEVTPHCI WIDFLVQRFE IAKYCSSDQV EIFSSLLQRS
MSLNIGGAKG SMNRHVAAIG PRFKLLTLGL SLLHADVVPN ATIRNVLREK IYSTAFDYFR
RLILEATMSL PTDNQDTRSN LDIAVGSRQQ ATQGWINTYP LSSGMSTISK KSGMSKKTNR
GSQLHKYYMK RRTLLLSLLA TEIERLTTWY NPLSAPELEL DQAGENSVAN WRSKYTSLSE
KQWKDNVNLA WSISPYLAVQ LPARFKNTEA IGSEVTRLVR LDPGAVSDIP EAIKFLVTWH
TIDADAPELS HVLCWAPADP PTGLSYFSSM YPPHPLTAQY GVKVLRSFPP DAILFYIPQI
VQALRYDKMG YVREYILWAA SKSQLLAHQF IWNMKTNIYL DEEGHQKDPD IGDLLEQLVE
EITGSLSGPA KDFYQREFDF FNKITNVSAI IKPYPKGDER KKACLAALSE VKVQPGCYLP
SNPEAIVLDI DYKSGTPMQS AAKAPYLAKF KVKRCGVSEL EKEGLRCCSD AEDQGGTQEA
DGQKISWQAA IFKVGDDCRQ DMLALQIIDL FKNIFQLVGL DLFVFPYRVV ATAPGCGVIE
CIPDCTSRDQ LGRQTDFGMY DYFTRQYGDE STLAFQQARY NFIRSMAAYS LLLFLLQIKD
RHNGNIMLDK KGHIIHIDFG FMFESSPGGN LGWEPDIKLT DEMVMIMGGK MEATPFKWFM
EMCVRGYLAV RPYMDAVVSL VTLMLDTGLP CFRGQTIKLL KSRTYDMIQY YQNDIPY
//