ID S7NB15_MYOBR Unreviewed; 1344 AA.
AC S7NB15;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902, ECO:0000256|PIRNR:PIRNR000619};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902, ECO:0000256|PIRNR:PIRNR000619};
GN ORFNames=D623_10009165 {ECO:0000313|EMBL:EPQ14236.1};
OS Myotis brandtii (Brandt's bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ14236.1, ECO:0000313|Proteomes:UP000052978};
RN [1] {ECO:0000313|Proteomes:UP000052978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23962925; DOI=10.1038/ncomms3212;
RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA Krogh A., Wang J., Gladyshev V.N.;
RT "Genome analysis reveals insights into physiology and longevity of the
RT Brandt's bat Myotis brandtii.";
RL Nat. Commun. 4:2212-2212(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC kinase family. EGF receptor subfamily. {ECO:0000256|PIRNR:PIRNR000619}.
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DR EMBL; KE163877; EPQ14236.1; -; Genomic_DNA.
DR eggNOG; KOG1025; Eukaryota.
DR Proteomes; UP000052978; Unassembled WGS sequence.
DR GO; GO:0098590; C:plasma membrane region; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:UniProtKB-UniRule.
DR CDD; cd00064; FU; 3.
DR CDD; cd05111; PTK_HER3; 1.
DR Gene3D; 1.20.890.10; cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain; 1.
DR Gene3D; 3.80.20.20; Receptor L-domain; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR006211; Furin-like_Cys-rich_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR032778; GF_recep_IV.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR000494; Rcpt_L-dom.
DR InterPro; IPR036941; Rcpt_L-dom_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
DR PANTHER; PTHR24416:SF88; RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF00757; Furin-like; 1.
DR Pfam; PF14843; GF_recep_IV; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF01030; Recep_L_domain; 2.
DR PIRSF; PIRSF000619; TyrPK_EGF-R; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00261; FU; 5.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR000619};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|PIRNR:PIRNR000619};
KW Membrane {ECO:0000256|PIRNR:PIRNR000619, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR000619};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR000619};
KW Reference proteome {ECO:0000313|Proteomes:UP000052978};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR000619};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|PIRNR:PIRNR000619}.
FT TRANSMEM 648..672
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 715..972
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1085..1153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1186..1220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1237..1259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1115..1134
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 721..729
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000619-2"
FT BINDING 748
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000619-2"
SQ SEQUENCE 1344 AA; 148113 MW; 569AF8E41672ED09 CRC64;
MPKQCTLLGG PAGRGAETLV LVNVRWLEVV ILEKVCPGTL NGLSVTGDAE NQYQTLHKQY
ERCEVVMGNL EIVLTGHNAD LSFLQWIREV TGYVLVAMNE FSTLPLPNLR VVRGTQVYDG
KFAIFVMLNY NTNSSHALRQ LGFTQLTEIL SGGVYIEKND KLCHMDTIDW RDIVRDRDAE
IVVKDNGRSC EPCHEVCKGR CWGPGPKDCQ TLTKTICAPQ CNGHCFGPDP NQCCHDECAG
GCSGPQDTDC FACRLFNDSG ACVRQCPQPL VYNKLTFQLE PNPHTKYQYG GVCVASCPHN
FVVDQTSCVR ACPPDKMEVD KNGLKICEPC GGLCPKACEG TGSGSRYQTV DSSNIDGFVN
CTKILGNLDF LITGLNGDPW HKIPALDPEK LSVFRTVREI TGYLNIQSWP PHMHNFSVFS
NLTTIGGRSL YNRGFSLLIM KNLNITSLGF RSLKEISAGR IYISANRQLC YHHSLNWTRL
LRGPSEERLD IKHNRLRRDC VAEGKVCDPL CSGGCWGPGP GQCLSCRNYS RGGVCVTHCN
FLNGEPREFA HEAECFPCHP ECQPMEGTAT CNGSGSDACA QCAHFRDGPH CVSSCPSGVL
GAKGPIYKFP DAQNECRPCH ENCTQGCNGP DLQDCLGQTQ AMISKTHLAM ALAVVVGLVV
IFVILGSTIL YLRGRRIQNK RAMRRYLERG ESIEPLDPSE KANKVLARVF KETELRKLKV
LGSGVFGTVH KGVWIPEGES IKIPVCIKVI EDKSGRQSFQ AVTDHMLAIG SLDHAHIVRL
LGLCPGSSLQ LVTQYLPLGS LLDHVRQHRG SLGPQLLLNW GVQIAKGMYY LEEHGMVHRN
LAARNVLLKS TSQVQVADFG VADLLPPDDK QLLHSEAKTP IKWMALESIH FGKYTHQSDV
WSYGVTVWEL MTFGAEPYAG LRLAEVPDLL EKGERLAQPQ ICTIDVYMVM VKCWMIDENI
RPTFKELANE FTRMARDPPR YLVIKRESGP GIPPGAEPPA LTNKELEEVE LEPELDLDLD
LEAEEDNLAT TLGSALSLPV GTLTWPRGSQ SLTSPSSGYM PMNQSNLGEA CQEPVVCGGE
RCPRPASLHP MPRGRMVSES SEGHVTGSEA ELQEKVSMCR SRSRSPRPRG DSAYHSQRHS
LLTPVTPLSP PGLEEEDVNG YVMPDAHLKG TPSSREGTLS SVGLSSVLGT EEEDEDEEYE
YMNRRRRHSP PRPPRPGSLE ELGYEYMDVG SDLSASLGST QSCPLHPVPI IPTPGTTPDE
DYEYMNKRRG GGGAGGDYAA MGACPAAEQG YEEMKAFQGP GHHAPQVHYT RLKTLRSLEA
TDSAFDNPDY WHSRLFPKAN AQRT
//
