ID S7NKN9_MYOBR Unreviewed; 3588 AA.
AC S7NKN9;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Lysosomal-trafficking regulator {ECO:0000313|EMBL:EPQ17130.1};
GN ORFNames=D623_10010299 {ECO:0000313|EMBL:EPQ17130.1};
OS Myotis brandtii (Brandt's bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ17130.1, ECO:0000313|Proteomes:UP000052978};
RN [1] {ECO:0000313|Proteomes:UP000052978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23962925; DOI=10.1038/ncomms3212;
RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA Krogh A., Wang J., Gladyshev V.N.;
RT "Genome analysis reveals insights into physiology and longevity of the
RT Brandt's bat Myotis brandtii.";
RL Nat. Commun. 4:2212-2212(2013).
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DR EMBL; KE164339; EPQ17130.1; -; Genomic_DNA.
DR eggNOG; KOG1786; Eukaryota.
DR Proteomes; UP000052978; Unassembled WGS sequence.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF163; LYSOSOMAL-TRAFFICKING REGULATOR; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000052978};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 2796..2902
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2907..3209
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 3399..3440
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 115..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 743..774
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 823..843
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 915..996
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1078..1104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1845..2018
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2457..2476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 115..130
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..218
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 915..934
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1869..1887
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1929..1953
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1991..2015
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2457..2472
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3588 AA; 399053 MW; 42AFE9C274090FA3 CRC64;
MSTDSNSLAR EFLTDVNRLC NAVVQQVEAR EEEEEEEEEE ETHMAALGQY LVHGRGFLLL
TKLNSTIDQA LTCREELLTL LLSLLPLVWK IPVQEERAAD FNLPFSVDII LTKEKNSSSQ
RSTQEKLHLE GSAPSGQVSA KVKSRRQRKA THACSVRDAR KTQLSTSGSE ADSDDRRPRR
PHQLQPLVAQ ASKEGAPAAH PNRSSTREQT PPETMASGSF QEMMPSQEAN TDILSEPAAL
SIISHMSNSP FDLCHVLLSL LEKVCKFDMN LNHNSALAAS VVPTLTEFLA GFGDCCDLGD
NAESQVVAAG WTEEPVALIQ RMLFRTVLHL MSVDVSAAGT MPDSLKKNLT ELLRAALKIR
TCLEKQPDPF APRQKTTLQE VREGFVFSRC RHRALLLPEL LEGVLQLLTC CLHSAASNPF
FFSQAMDLVQ EFIQHHGFHL FETAVLQMEW LILRDGVPAE ASERLRALIN GVLKIMSTVK
KVLAGVQDVG LCCCMDPKSV IVPLLHAFKL PALKNFQQQI LNVLSRLILD QLGGAEMPPR
MKKAACNICT VDSDQLAKLE ETLQGPARDE EPSWGLPSPY RCPGILPSSG SEDMLWRWDA
LEAYQNFVFE EDRLHSVQIA NHICSLMQKG NVVVRWKLYN YIFNPVLQRG VELAHHCQHP
GVPPAQTHVC GRQNQCLPHE VLQVYLKTLP SLLKSRVIRD LFLSCNGVSQ IIELNYLDGI
RGHSLKAFET LIISLGEQQK DCSIPGTDGL DGEPKEPASF HAGTSVHSQQ AFSDSPQSLS
KFYASLREAH PKRRKSAPHD AHLHTINLFL CVAFLCVSKE ADSDGEPAND SEDTSGYDST
ASEPLRQELP CLPLESLVLP PPERMHQAAD IWSMCRWIYM LSPAFQKQLC RLGGVRVCHK
LIFMIIQRLF RGPDEEHGKK EDQEPLRTAH SEVTVEEDLG SSAVRSAPTP SGPGGPEGSA
GSVGASESRA ASTNGDPIPA AGAAPEEAKG PASRASETSL QSIRLLEALL AICLHGTRAS
QHRAELEPPG QNLSVENILF EMRDHLSRSK VIETELAKPL FDALLRVALG NHAADFEHSD
AVTEKSPQSE EELSSQPGEF SEEAEDATCC GFKLLVEEEG YEADSESNSE DSEAQDDGVD
VKPEAEGFIA LSSPSDLLEN LTQGEIIYPE ICMLELNLLS TSKAKLDVLA HVFESFLKII
RQKEKNIFLL IQQGTVKNLL GGFLSILTQA DSDFQACQRG LVDLLVSLMS SRTCSEELTL
LLRIFLEKSP CTEILLLGIL KIVESDVAVS PLQYLTFPFL HTLNLSNGVS SPKCPGILSS
KAMGLLRRAR VSWSRKEVDS DSVPQQLLSS WHVAPVHLPL LGQNCWPHLS EGFSVSLWFN
VECVHEAESC SENRRKIRKR KKSSSLRDSS FDGAENDGLE GAEHAHPGER LIEGGCIHLV
SLGSKALMIQ VWAEPLTGTF IFRLCVDSND DAKAILLAQA ESLENVFLPR KWQHLVLTYF
QQPQGKKNLH GKISMWVSGQ RKPDVTLDFM LPRKTSLSSD SNKTFCMIGH SLSSQEEFLP
LAGKWHLGNL LLFNGAKVGS QEAFYLYACG PSHTSIMPCK HGTPASDYSK YINKDILQCD
QIRELFMTKK DVDIGLLIES LSVVYTSSCP AQYTIYEPVI RLKGQARAPL SQRPFSSKDV
QSVSLEPHQL RSLRPAECET LQGVLHEIGG TGIFVFLFAR VVELSSCEET QALALRVILS
LIRYNQQRIQ ELENCHGLSM IHQVLIKPKC TVGFHILKTL LEGCCGEEIL HVDENGEFTL
DVESKALIQD VKLLEELLLD WKVWRKAEAH GKIFQEKVDS IVSLRHSSSG GRAGPRPGLM
LISPSGFTAS PPEGHSSSGS IPPRTGASLR RSRSLPALPT SSLVPPRTLA GGSDGGLNRV
PSAAGSPAAP QPEQWNSPGS SETLKQGEEE ASISSCESAE AVCEGDAGLP QPASVGGVPR
GTPECPGVGV DQKELEAESR ADGDGPGDAS YPRRPDDLRG LASFQRSQST VASLGLAFPS
QSGSAPMRRW PSLVDRSAED WASLAFSPGY EPNYLRTAHT PRVTEDALVP ICCGLYELLS
GVLLILPDAM LEDVMDKLIQ AEVLLVLVNH PSPAIQRGVI QLLDVYFNRA SKEQKDKFLK
NRGFSLLANQ LYLHRATPEL LDCFVEMFFG RHIGPDDEFD QEDVRNLGLF QKWAVIPVLG
LIETSLYDNT LLHNALLLLL QILNSCSKVA DMLLDNGLLY VLCNTVAALN GLEKNIPLNE
YKLLACDIQQ LLVAVTIHAC SSSGPQYFRV IEDLIVLLGY LQNSKNKRTQ SMAVALQFRV
LQAAMEFIRT TANHDSDSFT ECFQAPSPQH AVFPKRKSIA GPWKCPLAHS DPFLMRMRSV
ASDELHVMIQ RRMSQESPGQ ASEAELVQRL QRLIVLAVNR LIYQEFNPDA VAILSTPENA
TQSKTSASQT EISEENSHRE QISVFNPFQK EILAYLIEGF KVSVGSSKPS GSKQQWAKIV
WSCKDTFRMQ LGRLLAHILS PAHPSQERKQ IFEIVQEPNH QEILRDCLSP SLQHGAKLVL
YLSELIHNHP EELTWEELDA AQLLMSALQT CGHRGPPPSA AAKPELLRVI REEQKKYETE
EGVNKATWQK TVKNNQQSLF QRLDSKSKEI SKTAADITQA VSLSQGIERK KVIQHIRGMY
KVDLSASRHW QELSQQLTHD RAVWYDPTYY PTSWQLDPTE GPNRERRRLQ RCYLTIPNKY
LLRDRQRPEG MVRPPLSYLF EDKTHSSFSS TVKDKAASES IRVNRRCISV APSRETAGEL
LLGKCGMYFV EDNASDTVES SSPQGELEPA SFSWTYEEIK EVHKRWWQLR DNAVEIFLTN
GRTLLLALDS TKVRDDVYHS ILNNDLPNLL EYGNITALTN LWYTGQITNF EYLTHLNKHA
GRSFNDLMQY PVFPFILADY VSETLDLGDP SVYRNLSKPI AVQYKEKEDR YVDTYKYLEE
EFRKGAREDD PLPPVQPYHY GSHYSNSGTV LHFLVRMPPF TRMFLAYQDQ SFDIPDRTFH
SMNTTWRLSS FESMTDVKEL VPEFFYLPEF LVNREGFDFG LRQNGERVNH VNLPPWARND
PRLFILIHRQ ALESDHVSQN ICQWVDLVFG YKQKGKASVH AINVFHPATY FGMDVSAVED
PVQRRALETM IKTYGQTPRQ LFQAAHVSRP GPRLSLEGEL PAAVGLLVQF AFRETREPVR
EAPHPSPLSW IKGLKWGEYV GSPSAPMPVV CFSQPHGERL GSLQALPTRA ICGLSQNFCL
LVTYSKEQGV RSMNSTDIQW SAILSWGYAD NILRLKSKQS EPPVNFIQSS QQHQVTSCAW
VPDSCQLFTG SRCGVITAYA NRMAGSAPSE IEMESQVHLY GHTEEVTSLF VCKPYSILIS
VSRDGTCIIW DLNRLCYVQT LAGHKSPVTA VSASETTGDI ATVCDSAGGG SDLRLWTVNG
DLVGHVHCRE VICSVAFSNQ PEGVSINVIA GGLENGTVRL WSTWDLKPVR EITFPKSNKP
IVSLTFSCDG HHLYTANSEG TVIAWCRKDQ QRLKQPMFCS FLSSYAAG
//
