ID S7NPL6_MYOBR Unreviewed; 961 AA.
AC S7NPL6;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Phosphoinositide 3-kinase adapter protein 1 {ECO:0000313|EMBL:EPQ19714.1};
GN ORFNames=D623_10025724 {ECO:0000313|EMBL:EPQ19714.1};
OS Myotis brandtii (Brandt's bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ19714.1, ECO:0000313|Proteomes:UP000052978};
RN [1] {ECO:0000313|Proteomes:UP000052978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23962925; DOI=10.1038/ncomms3212;
RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA Krogh A., Wang J., Gladyshev V.N.;
RT "Genome analysis reveals insights into physiology and longevity of the
RT Brandt's bat Myotis brandtii.";
RL Nat. Commun. 4:2212-2212(2013).
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DR EMBL; KE164716; EPQ19714.1; -; Genomic_DNA.
DR AlphaFoldDB; S7NPL6; -.
DR eggNOG; ENOG502QS94; Eukaryota.
DR Proteomes; UP000052978; Unassembled WGS sequence.
DR GO; GO:0005762; C:mitochondrial large ribosomal subunit; IEA:InterPro.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 6.20.130.20; Mitochondrial ribosomal protein L55; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR017893; DBB_domain.
DR InterPro; IPR041340; PIK3AP1_TIR.
DR InterPro; IPR018615; Ribosomal_mL55.
DR InterPro; IPR044884; Ribosomal_mL55_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR16267; BANK1/PIK3AP1 FAMILY MEMBER; 1.
DR PANTHER; PTHR16267:SF12; PHOSPHOINOSITIDE 3-KINASE ADAPTER PROTEIN 1; 1.
DR Pfam; PF14545; DBB; 1.
DR Pfam; PF09776; Mitoc_L55; 1.
DR Pfam; PF18567; TIR_3; 1.
DR SMART; SM01282; DBB; 1.
DR PROSITE; PS51376; DBB; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:EPQ19714.1};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000052978};
KW Transferase {ECO:0000313|EMBL:EPQ19714.1}.
FT DOMAIN 32..169
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT DOMAIN 205..341
FT /note="DBB"
FT /evidence="ECO:0000259|PROSITE:PS51376"
FT REGION 169..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 554..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 679..698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 722..814
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 679..694
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 741..769
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 961 AA; 109013 MW; 2057508FDEC25AB6 CRC64;
MPVEALSPEV LKDKKIHVIK SLEGLHNIRV FRRCDILLVY SPDAEEWCQY LQDLFLSSRQ
VRGQKTLTYR LGPDTFFSAE DLTFFLSTRC IVVLLSAELV QHFGQPAQLP LLQRAFHPPQ
RMVRLLCGVQ NSKEFLDFFP EWAHWQELTC DDEPETYVAA VKKAISEDSG CDSVTDTETE
DEKVPPYSKQ QSLPLETSPG NLMVVQPDRI RCGAETTVYI IVRCKLDERV TTEAEFSPED
SPSIRVEGKL ENEYTVSVKA PALSSGNVSL KIYSGDLVVC EARISYYTDM EEIGNLLSNA
ANPVEFMCQA FKIVPYNTET LDKLLTESLK NNIPASGLHL FGINQLEEED MMTNQRDEEL
PTLLHFAAKY GLKNLTALLL TCPGALQAYS VANKHGHYPN TIAEKHGFRD LRQFIDEYVE
TVDMLKSHIK EELMQGEEAD DVYESMAHLS TDLLMKCSLN PGCDEELYES MAAFVPDATE
DLYVEMLQAS TSNPIAGESF SRNTKDSMIR KFLEGNNVGI ATLEKEPFHH DPEDVYHTVE
DDEAFSLDLA SRPPVPVPRP EASASGAHQV PDNEPYISKG KFFAEKSQER PGNFYVSSES
IRKEPPVRPW RDRPPSSIYD PFAGMKTPGQ RQLITLQEQV KLGIVNVDEA VLHFKEWQLN
QKKRSESFRF QQENLKRLRD SITRRQREKQ KTGKQTALEI TVPIRHSQLL PSKVEIGVYE
SGPRKSVFPP RTELRRGDWK TDSTSSTASS TSNRSSTRSL LSVSSGMEGD NEDNEVPEVT
RSRSPGPLQV DGTPTLPIDR PPRVPPRAAS QRPTLVAEWG QEGIMMIFVV EDRRGMAVVG
SMLGLLQQHV VIGAAPVVRC LHISSRWADS SRASLTRVHR QAYARLYPML LVKQDGSTIH
IRYREPRRML AMPVDLDALS PEERRARFRK REAQLRGKEE QQPELLDNFD LERYKQFWTK
K
//
