ID S7NR63_MYOBR Unreviewed; 1257 AA.
AC S7NR63;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Neural cell adhesion molecule L1 {ECO:0000313|EMBL:EPQ20194.1};
GN ORFNames=D623_10010683 {ECO:0000313|EMBL:EPQ20194.1};
OS Myotis brandtii (Brandt's bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ20194.1, ECO:0000313|Proteomes:UP000052978};
RN [1] {ECO:0000313|Proteomes:UP000052978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23962925; DOI=10.1038/ncomms3212;
RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA Krogh A., Wang J., Gladyshev V.N.;
RT "Genome analysis reveals insights into physiology and longevity of the
RT Brandt's bat Myotis brandtii.";
RL Nat. Commun. 4:2212-2212(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily.
CC L1/neurofascin/NgCAM family. {ECO:0000256|ARBA:ARBA00008588}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KE164798; EPQ20194.1; -; Genomic_DNA.
DR RefSeq; XP_005886195.1; XM_005886133.2.
DR AlphaFoldDB; S7NR63; -.
DR GeneID; 102260104; -.
DR KEGG; myb:102260104; -.
DR CTD; 3897; -.
DR eggNOG; KOG3513; Eukaryota.
DR OrthoDB; 2912783at2759; -.
DR Proteomes; UP000052978; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 5.
DR CDD; cd05876; Ig3_L1-CAM; 1.
DR CDD; cd05867; Ig4_L1-CAM_like; 1.
DR CDD; cd05845; IgI_2_L1-CAM_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 10.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR026966; Neurofascin/L1/NrCAM_C.
DR PANTHER; PTHR44170:SF44; L1 CELL ADHESION MOLECULE; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF13882; Bravo_FIGEY; 1.
DR Pfam; PF00041; fn3; 4.
DR Pfam; PF07679; I-set; 3.
DR Pfam; PF13927; Ig_3; 2.
DR SMART; SM00060; FN3; 4.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 5.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS50835; IG_LIKE; 6.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000052978};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1257
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004554865"
FT TRANSMEM 1122..1144
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 35..129
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 139..226
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 240..328
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 333..421
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 426..514
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 519..608
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 615..713
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 718..811
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 813..919
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 922..1018
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 697..727
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1154..1207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1226..1257
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1154..1185
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1257 AA; 140196 MW; C91C9C1A39BEC7A5 CRC64;
MAVALRYLWP LLLCSPCLFI QIPDEYEGQH VMEPPVITEQ SPRRLVVFPT DEISLKCEAS
GKPEVMFRWT RDGIHFKPNE ELDVTVKQAP HSGSFTIAGN NSNFAQRFQG TYRCFASNDL
GTAMSHEIQL MAEGAPKWPK ETVKPVEVEE GESVILPCHP PPSAEPLRIY WMNSKIMHIK
QDERVTMGQN GNLYFANVLT SDNHSDYICH AHFPGTRTII QKEPIDLRVK ATNSMIDRKP
RLLFPTNASS HLVALQGQPL VLECIAEGFP TPTIKWLRPS GPMPADRVTY QNHNKTLHLL
NVGEEDDGEY RCLAENSLGS DRHAYYVTVE AAPYWLHKPQ SRLYGPGETA RLDCQVQGRP
EPEVTWRING IPVEELPAKD QKYRIQHGAL ILSNVQPSDT MVTQCEARNR HGLLLANAYI
YVVQLPAKIL TPDNETYLAV EGSTAYLLCK VFGAPVPSVQ WLDKEGKTVL QDERFFPYTN
GTLGIRDLQA NDTGHYFCQA ANDQNNVTIV ANLQVKDATR ITQGPQSTIK KKGSRVTFTC
QATFDPSLQQ SITWRRDGRS LQEPGDSDKY FIEDGHLVIH SLDYSDQGNY SCVASTKLDV
VESRAELQVV GSPGPVPQLE LSDRHLLKQS QVRLSWSPAD DHNAPIEKYD IEFEDKEMAP
EKWYSLGKVP GNQTSTTLKL SPYVHYTFRV TAINKYGPGE PSPASETVVT PEAAPEKNPV
DVKGEGNETN NMVITWKPLR WMDWNAPQVQ YRVQWRPQGT RGTWQEQIVS DPFLVVSNTS
TFVPYEIKVQ TINSQGKGPE PQVTIGYSGE DYPQAKPKLE DIKILNASTV LVKWWPVDPA
QVKGHLRGYN LTYSWEGSPK RHSKRHIPES HVVVVPANTT STVLDGLRPY SSYRLELRAF
NSRGLGPPSN TTFSTPEGVP GPPEALHLEC QSDTSLLLHW QPPFSHNGVL TGYVLSCLPL
GDGGEEQLSF NLSDPELRSY NLTNLSPHLQ YRFQLQATTK QGPGEAITRE GGTKTLTGTS
DFGDVSTTVG ENYSVVSWVP KEGQCNFGFQ ILFKPLSDEK MDAIPPQYVS YNQRSYTQWD
LQPGTNYQIQ LLKEAVLLHE TFVTTNGTGR VRLPPPGFTT EGWFIGFVSA IILLLLILLI
LCFIKRSKGG KYSVKDKEDT QVDSEARPMK DETFGEYRSL ESDNEEKAFS SQPSLNGDIK
PLGSDDSLAD YGGSVDVQFN EDGSFIGQYS GKKEKEAAGG NDSSGAASPI NPTGTLE
//
