GenomeNet

Database: UniProt
Entry: S7NTD6_MYOBR
LinkDB: S7NTD6_MYOBR
Original site: S7NTD6_MYOBR 
ID   S7NTD6_MYOBR            Unreviewed;       572 AA.
AC   S7NTD6;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   24-JAN-2024, entry version 46.
DE   RecName: Full=microtubule-severing ATPase {ECO:0000256|ARBA:ARBA00038871};
DE            EC=5.6.1.1 {ECO:0000256|ARBA:ARBA00038871};
DE   AltName: Full=60S ribosomal protein L21 {ECO:0000256|ARBA:ARBA00035327};
GN   ORFNames=D623_10019013 {ECO:0000313|EMBL:EPQ20130.1};
OS   Myotis brandtii (Brandt's bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC   Myotis.
OX   NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ20130.1, ECO:0000313|Proteomes:UP000052978};
RN   [1] {ECO:0000313|Proteomes:UP000052978}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23962925; DOI=10.1038/ncomms3212;
RA   Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA   Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA   Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA   Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA   Krogh A., Wang J., Gladyshev V.N.;
RT   "Genome analysis reveals insights into physiology and longevity of the
RT   Brandt's bat Myotis brandtii.";
RL   Nat. Commun. 4:2212-2212(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1)
CC         alpha/beta tubulin heterodimers.; EC=5.6.1.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00036378};
CC   -!- SIMILARITY: Belongs to the AAA ATPase family.
CC       {ECO:0000256|ARBA:ARBA00006914, ECO:0000256|RuleBase:RU003651}.
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL21 family.
CC       {ECO:0000256|ARBA:ARBA00008427}.
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DR   EMBL; KE164790; EPQ20130.1; -; Genomic_DNA.
DR   AlphaFoldDB; S7NTD6; -.
DR   eggNOG; KOG0740; Eukaryota.
DR   Proteomes; UP000052978; Unassembled WGS sequence.
DR   GO; GO:0031090; C:organelle membrane; IEA:UniProt.
DR   GO; GO:0005840; C:ribosome; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0006412; P:translation; IEA:InterPro.
DR   Gene3D; 1.10.8.60; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   Gene3D; 1.20.58.80; Phosphotransferase system, lactose/cellobiose-type IIA subunit; 1.
DR   Gene3D; 2.30.30.70; Ribosomal protein L21; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR041569; AAA_lid_3.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR003960; ATPase_AAA_CS.
DR   InterPro; IPR007330; MIT_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001147; Ribosomal_eL21.
DR   InterPro; IPR036948; Ribosomal_eL21_sf.
DR   InterPro; IPR015415; Spast_Vps4_C.
DR   InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR   PANTHER; PTHR23074; AAA DOMAIN-CONTAINING; 1.
DR   PANTHER; PTHR23074:SF86; SPASTIN; 1.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF17862; AAA_lid_3; 1.
DR   Pfam; PF01157; Ribosomal_L21e; 1.
DR   Pfam; PF09336; Vps4_C; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00745; MIT; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF50104; Translation proteins SH3-like domain; 1.
DR   PROSITE; PS00674; AAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU003651};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW   Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU003651};
KW   Reference proteome {ECO:0000313|Proteomes:UP000052978}.
FT   DOMAIN          105..174
FT                   /note="MIT"
FT                   /evidence="ECO:0000259|SMART:SM00745"
FT   DOMAIN          354..466
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   REGION          195..289
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        195..209
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        222..236
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        265..285
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   572 AA;  63814 MW;  3774284F0EEE47E5 CRC64;
     MTNTKGKRRG TRYMHFRKHG VVPLATYMRI YKKGDIVDIK GMGTVQKGMP QKCYHGKTES
     VYNVTQHAVG IIVNKQVKGK VLAKRILHIE HIKHSMSRHS FLKRVKENDQ KKKEAKEKAG
     QKEQAMEWYK KGIEELEKGI AVIVTGQGEQ CERARRLQAK MMTNLVMAKD RLQLLEKLQP
     VLQFSKSQTD VYNDSTNLTC RNGQLQSESG AVPKRKDPLT HPSNSLPRSK TVMKAGSTGL
     SGHHRAPSCS GLSMVSGVRQ GPGPATATHK STPKTNRTNK PSTPTTAARK KKDLKNFRNV
     DSNLANLIMN EIVDNGTAVK FDDVAGQELA KQALQEIVIL PSLRPELFTG LRAPARGLLL
     FGPPGNGKTM LVGEGEKLVR ALFAVARELQ PSIIFIDEVD SLLCERREGE HDASRCLKTE
     FLIEFDGVQS AGDERVLVMG ATNRPQELDE AVLRRFTKRV YVSLPNEETR RLLLKNLLCK
     QGSPLTQKEL AQLARMTDGY SGSDLTALAK DAALGPIREL KPEQVKNMSA NEMRNIRLSD
     FTESLKKIKR SVGPQTLEAY IRWNKDFGDT TV
//
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