ID S7P1S6_MYOBR Unreviewed; 414 AA.
AC S7P1S6;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Heterogeneous nuclear ribonucleoprotein F {ECO:0000256|ARBA:ARBA00044148};
GN ORFNames=D623_10002118 {ECO:0000313|EMBL:EPQ01437.1};
OS Myotis brandtii (Brandt's bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ01437.1, ECO:0000313|Proteomes:UP000052978};
RN [1] {ECO:0000313|Proteomes:UP000052978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23962925; DOI=10.1038/ncomms3212;
RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA Krogh A., Wang J., Gladyshev V.N.;
RT "Genome analysis reveals insights into physiology and longevity of the
RT Brandt's bat Myotis brandtii.";
RL Nat. Commun. 4:2212-2212(2013).
CC -!- FUNCTION: Component of the heterogeneous nuclear ribonucleoprotein
CC (hnRNP) complexes which provide the substrate for the processing events
CC that pre-mRNAs undergo before becoming functional, translatable mRNAs
CC in the cytoplasm. Plays a role in the regulation of alternative
CC splicing events. Binds G-rich sequences in pre-mRNAs and keeps target
CC RNA in an unfolded state. {ECO:0000256|ARBA:ARBA00043862}.
CC -!- SUBUNIT: Identified in the spliceosome C complex. Interacts with AGO1,
CC AGO2, TBP and TXNL4/DIM1. {ECO:0000256|ARBA:ARBA00044002}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm
CC {ECO:0000256|ARBA:ARBA00004642}.
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DR EMBL; KE161047; EPQ01437.1; -; Genomic_DNA.
DR AlphaFoldDB; S7P1S6; -.
DR eggNOG; KOG4211; Eukaryota.
DR Proteomes; UP000052978; Unassembled WGS sequence.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd12729; RRM1_hnRNPH_hnRNPH2_hnRNPF; 1.
DR CDD; cd12731; RRM2_hnRNPH_hnRNPH2_hnRNPF; 1.
DR CDD; cd12506; RRM3_hnRNPH_CRSF1_like; 1.
DR Gene3D; 3.30.70.330; -; 3.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR012996; Znf_CHHC.
DR PANTHER; PTHR13976:SF32; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN F; 1.
DR PANTHER; PTHR13976; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED; 1.
DR Pfam; PF00076; RRM_1; 2.
DR Pfam; PF08080; zf-RNPHF; 1.
DR SMART; SM00360; RRM; 3.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 3.
DR PROSITE; PS50102; RRM; 2.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Reference proteome {ECO:0000313|Proteomes:UP000052978};
KW Ribonucleoprotein {ECO:0000313|EMBL:EPQ01437.1};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 110..187
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 288..365
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
SQ SEQUENCE 414 AA; 45671 MW; E6F850904D77568D CRC64;
MLGPEGGEGF VVKLRGLPWS CSIEDVQNFL SGCIIHDGSA GIHFIYTREG RQSGEAFVEL
ESEDDVKMAL KKDRESMGHR YIEVFKSHRT EMDWVLKHSG PNSADTANDG FVRLRGLPFG
CTKEEIVQFF SGLEIVPNGI TLPVDPEGKI TGEAFVQFAS QELAEKALGK HKERIGHRYI
EVFKSSQEEV RTYSDPPLKF MSVQRPGPYD RPGTARRYIG IVKQAGLDRM RSGAYSAGYG
GYEEYSGLSD GYGFTADMFG RDLSYCLSGV YDHRYGDGEF TVQSTTGHCV HMRGLPYKAT
ENDIYNFFSP LNPVRVHIEI GPDGRVTGEA DVEFATHEEA VAAMSKDRAN MQHRYIELFL
NSTTGASNGA YSSQMMQGMG VSAQSTYSGL ESPSVSGCYG AASYRGQNSM TGYD
//
