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Database: UniProt
Entry: S7P3U8_MYOBR
LinkDB: S7P3U8_MYOBR
Original site: S7P3U8_MYOBR 
ID   S7P3U8_MYOBR            Unreviewed;      1621 AA.
AC   S7P3U8;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   10-MAY-2017, entry version 26.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   ORFNames=D623_10034907 {ECO:0000313|EMBL:EPQ02262.1};
OS   Myotis brandtii (Brandt's bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera;
OC   Vespertilionidae; Myotis.
OX   NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ02262.1, ECO:0000313|Proteomes:UP000052978};
RN   [1] {ECO:0000313|Proteomes:UP000052978}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23962925; DOI=10.1038/ncomms3212;
RA   Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA   Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D.,
RA   Hee Yim S., Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N.,
RA   Chen G., Kulakova O.I., Sun Y., Lee S.G., Bronson R.T., Moskalev A.A.,
RA   Sunyaev S.R., Zhang G., Krogh A., Wang J., Gladyshev V.N.;
RT   "Genome analysis reveals insights into physiology and longevity of the
RT   Brandt's bat Myotis brandtii.";
RL   Nat. Commun. 4:2212-2212(2013).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448,
CC       ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; KE161207; EPQ02262.1; -; Genomic_DNA.
DR   Proteomes; UP000052978; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   GO; GO:0006936; P:muscle contraction; IEA:InterPro.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028812; Na_channel_a7su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   PANTHER; PTHR10037:SF269; PTHR10037:SF269; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000052978};
KW   Ion channel {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000313|EMBL:EPQ02262.1};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000052978};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    113    132       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    144    164       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    235    255       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    364    388       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    504    524       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    582    600       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    734    755       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1014   1036       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1122   1149       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1206   1224       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1236   1258       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1270   1288       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1323   1351       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1427   1449       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN     1467   1502       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   1621 AA;  184319 MW;  157D4F637713EBFE CRC64;
     MASPEPKGLV PFTRESLELM EQRIAKKHNE EHEEDLKPNS DLEVGKELPF VYGNLPQGMV
     SEPLEDVDPY YQNKNTFMIL NKKRTIFRFN ATWCTLSPFN SIRRATVKIL QSTFFRLLIL
     ISVLIDCIFM SLTEGPKWGR ELQITLLAIY TFEILVKLIA RGIWTGSFYF FGDPWNWLDF
     SVTLFEHITI YSPLNFTPIF RVARSLRILK IIPLNQGVKS YVGILLQCLK KLTGVIILTL
     FFLIIFSLIG MGFFMGNLKH KCFRWPQENE TETLHNKTRN PCYSRETENF YYLEGERYAL
     LCGNRSDASQ CPEGYACIKT GMNPDNGYTN FDNFGWALLA LFRLMTQDYP EALYHQILYA
     SGKVYMIFFI IISFWFAFYM ASLFLGILAM SYEEEKRTAA EKTKKIETEF QHTLLQEENE
     AAEAKTTQIE MKKRSPTSMI TSLDMLDDAT IRHKEAELFL ANVHGLDVFR LFRVLRIFKL
     GKYWPTFEIL KLTLIKSLVA LKDLILLLYT FLFFSAVVGT KLFGLSYKAY VYNLDKDCQL
     PRWHMGDFFH SFLNVFRILC GEWVETLWDC FDTAGQFSCV PFYMMVILIG NLLGSAISGC
     EQQLWHQLQV RGGWHQQWVR VAAASPGRPS GAGVGEEALR GNRASSGHSH PLMVPSDQDQ
     CRALAVGARG EEALRGNQDS SGRSHPLMVP SDRDQCRALA VGAGRASTGS SLVPLLTCST
     ILLRLTPAMF RKRAMVILYL FLALVISFSS CNAATHAENE EAKNLQCAMA RIKKGICYVL
     SKILCKRLNV PKDTVDNVND THVKENISGH TLSELSNTED VLKDKGKSSG TEKTTVTENE
     SESLIPSPSA SETVPIASGE SDIENLDNKE IQSKSGYGSS KEKVKPSSSS ECSTVDIAIS
     EEEEMINEHE KPKHPKNSYE RRSSPGQISR ESKRGKIWRN IRKTCCKIVE NSFFKCFIGL
     VTLLSTGALV SEGKSQELKL LTSIKFLRAL RVLSQFERMK VVVRALMKTT LPALNVFLVC
     LMIWLAYSII GVHLFAGTFY ECIDPTSGER FPTYEVRNRS ECESLVFNES MPWENAKLNF
     DNVGNGFLSL LQVATFNGWI DIMNSAVDST GVHMQPDFEV NIYMYCYFIG FIIIGLFLPL
     TMLVGVILAN FNKHKIKISS NIFITEKQEK QYLTLKKLMY EDSRKTIPCP GNKFRRFIFD
     LVTSQAFNII IMVLICFQAI TLMIQSDEQS RQMDTAVLWL QILFIILYTG ECVLKLIAFR
     CNYFTSGWNV LDFIVVIFSI TGLLLPLIGE YYLVPPSFLQ LIVLSRIIHI LRPGKGPKVF
     HDLLLPLVLF LPALLNISLL IFLVMFIYAI FGMYNFAYVK KEAGINDVSN FETFGSSMLC
     LFQVTIFAGW DGMLNAIFNS KWSDCDPDKI NPGTQVRGDC GNPIVGIIYF VSYILIAWLI
     IVNMYIVLVM EFVNIASKKT AKTLSEDDFR KFFQVWRRFD PDGTQYIDSS KLSDFAAALD
     APLFMAKPNK GQLVAMDLPM AVGDRIHCLD ILLAFTKRVV GKDVRMEKLL SEMESGFILA
     NPFKITYEPI TTTLKRKQEA VSATIIQRAY KSYRLRQSDK KTSDIHMIDD DREVQATKED
     A
//
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