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Database: UniProt
Entry: S7P5S3_MYOBR
LinkDB: S7P5S3_MYOBR
Original site: S7P5S3_MYOBR 
ID   S7P5S3_MYOBR            Unreviewed;      1427 AA.
AC   S7P5S3;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   10-MAY-2017, entry version 29.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   ORFNames=D623_10031111 {ECO:0000313|EMBL:EPQ02972.1};
OS   Myotis brandtii (Brandt's bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera;
OC   Vespertilionidae; Myotis.
OX   NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ02972.1, ECO:0000313|Proteomes:UP000052978};
RN   [1] {ECO:0000313|Proteomes:UP000052978}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23962925; DOI=10.1038/ncomms3212;
RA   Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA   Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D.,
RA   Hee Yim S., Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N.,
RA   Chen G., Kulakova O.I., Sun Y., Lee S.G., Bronson R.T., Moskalev A.A.,
RA   Sunyaev S.R., Zhang G., Krogh A., Wang J., Gladyshev V.N.;
RT   "Genome analysis reveals insights into physiology and longevity of the
RT   Brandt's bat Myotis brandtii.";
RL   Nat. Commun. 4:2212-2212(2013).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; KE161298; EPQ02972.1; -; Genomic_DNA.
DR   Proteomes; UP000052978; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR008052; Na_channel_a4su_mammal.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   Pfam; PF00520; Ion_trans; 3.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01665; NACHANNEL4.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000052978};
KW   Ion channel {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000313|EMBL:EPQ02972.1};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000052978};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    129    156       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    168    191       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    203    227       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    248    276       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    335    361       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    596    614       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    635    657       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    663    683       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    712    738       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    836    859       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    917    935       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    947    965       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    977    998       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1061   1089       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1162   1188       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      139    365       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      375    590       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN      594    868       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      916   1197       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   1427 AA;  160220 MW;  D7F68887BA2D05EB CRC64;
     MASEWRVSKD EGPPSLWTTT RLSAGHEPPR GNGLHAHHPA GPQAKAAQAL EDAEAGGDPA
     HGKDCNGSLD TSPGEKGPPR PSCSADSAIS DAMEELEEAH QKCPPWWYKC AHKVLIWNCC
     APWMKFKNII HLIVMDPFVD LGITICIVLN TLFMAMEHYP MTEEFDHVLS VGNLVFTGIF
     TAEMVLKLIA LDPYEYFQQG WNIFDSIIVT LSLVELGLAN VQGLSVLRSF RLLRVFKLAK
     SWPTLNMLIK IIGNSVGALG NLTLVLAIIV FIFAVVGMQL FGKSYKECVC KIASDCSLPR
     WHMHDFFHSF LIIFRILCGE WIETMWDCME VAGQAMCLTV FLMVMVIGNL VVLNLFLALL
     LSSFSADSLA APDEDGEMNN LQIAIGRIKW GISFAKAFLL GLLHGKILSP KEIILQIGRL
     GEAEEAGEAG EAGESAPEDE KKEPPPKEGD KDLKDNHILN HVGLAHGPTP SIELDHLNFI
     NNPYLTIHVP IASEESDLEM PTEEETDTFS EAEDVKKLPQ SLDRNSSVCS TVDYKPPEED
     AEEQVEENPE GEQPEECFTE ACVQRCPCLY VDVSQGRGKT WWTLRRACFK IVEHNWFETF
     IVFMILLSSG ALAFEDIYIE QRPTIRTILE YADKVFTYIF ILEMLLKWVA YGFKVYFTNA
     WCWLDFLIVG VSIISLVANW MGYSELGPIK SLRTLRALRP LRALSRFEGM RVVVNALLGA
     IPSIMNVLLV CLIFWLIFSI MGVNLFAGKF YYCINTTTSE RFDISEVNNK SECESLMYTG
     QVRWLNVKVN YDNVGLGYLS LLQVATFKGW MDIMYAAVDS REQGEQPQYE VNLYMYLYFV
     IFIIFGSFFT LNLFIGVIID NFNQQKKKMR KDIFMTEEQK KYYNAMKKLG SKKPQKPIPR
     PQNKIQGVVY DFVTKQVFDI VIMILICLNM VTMMVETDDQ SQLKVDILYN INMIFIIIFT
     GECVLKMFAL RHYYFTVGWN IFDFVVVILS IAAYLTSIQL CGDKDVTPCP KTLGGPGLMG
     LALSELIQKY FVSPTLFRVI RLARIGRVLR LIRGAKGIRT LLFALMMSLP ALFNIGLLLF
     LVMFIYSIFG MSNFAYVKKE SGIDDMFNFE TFGNSIICLF EITTSAGWDG LLNPILNSGP
     PDCDPTLENP GSSVKGDCGN PSVGICFFCS YIIISFLIVV NMYIAIILEN FNVATEESGE
     PLCEDDFEMF YETWEKFDPD ATQFIEYSRL SDFVDTLQEP LRIAKPNKIK LITLDLPMVP
     GDKIHCLDIL FALTKEVLGD SGEMDALKET MEEKFMAANP SKVSYEPITT TLRRKHEEVC
     AIKIQRAYRR HLLQRSVKQA SYMYRHSQDG SGDGAPEKEG LIVNTMSKLY GPENGDSDVQ
     GKGEETGSTG DAGPAMGLTP ISPSDAALPP SPPPGQTVRP GVKESLV
//
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