ID   S7PGI1_MYOBR            Unreviewed;       683 AA.
AC   S7PGI1;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-MAR-2024, entry version 46.
DE   SubName: Full=Neuroepithelial cell-transforming protein 1 protein {ECO:0000313|EMBL:EPQ09738.1};
GN   ORFNames=D623_10019431 {ECO:0000313|EMBL:EPQ09738.1};
OS   Myotis brandtii (Brandt's bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC   Myotis.
OX   NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ09738.1, ECO:0000313|Proteomes:UP000052978};
RN   [1] {ECO:0000313|Proteomes:UP000052978}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23962925; DOI=10.1038/ncomms3212;
RA   Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA   Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA   Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA   Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA   Krogh A., Wang J., Gladyshev V.N.;
RT   "Genome analysis reveals insights into physiology and longevity of the
RT   Brandt's bat Myotis brandtii.";
RL   Nat. Commun. 4:2212-2212(2013).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KE162829; EPQ09738.1; -; Genomic_DNA.
DR   AlphaFoldDB; S7PGI1; -.
DR   eggNOG; KOG4305; Eukaryota.
DR   Proteomes; UP000052978; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd13224; PH_Net1; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR001331; GDS_CDC24_CS.
DR   InterPro; IPR037853; Net1_PH.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR46006:SF4; NEUROEPITHELIAL CELL-TRANSFORMING GENE 1 PROTEIN; 1.
DR   PANTHER; PTHR46006; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS00741; DH_1; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000052978}.
FT   DOMAIN          261..443
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          473..588
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          1..50
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          214..233
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          636..683
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        663..683
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   683 AA;  76661 MW;  E84ABC3BF0F4BFDB CRC64;
     MSDCSLGLLP TGKWTSPEGS RTARGMSDCQ LRLNPPGSGP KPAGGHPPRG SRLLLLELQQ
     LLHVHGLGHH SLFCKYPRVV RDPSGDVAVA KRQEAREEPE LGPGTMPLTL ILAHCTCCRH
     SVVLPLLSSA SVESGEAPTV AAALTSHEPN FWKRKRRAKD DDVVSLSSLD LKEPSNKRVR
     PLARVTSLAN LISPVRNGAV RRFGQTIQSF TLRGDNRSPA SAQKWSSRST VPTPAKRRSS
     VLWSEMLDVS MKESLTTKEI KRQEAIYEMS RGEQDLIEDL KLARKAYHDP MLKLSIMSEE
     ELTQIFGDLD AYIPLHEDLL ARLGEATKPS GTIEQIGDIL VNWLPGLNAY KGYCSNQLAA
     KALLDQKKQD PRVQDFLQRC LESPFSRKLD LWSFLDIPRS RLVKYPLLLK EILRHTPKDH
     PDVQLLEEAV LIIQGVLSDI NLKKGESECQ YYIDKLEYLD EKQKDPRIEA SKVLLCHGEL
     KNKNGHKLYI FLFQDILVLT RPVTRNDRHS YQVYRQPIPV QELVLEDLQD GDVRMGGSFR
     GAFSNSDKAK NIFRVRFQDP SPGQSHTLQA NDVFHKQQWF NCIRTAIAPF QQATSSPELQ
     GLPELHEEYE ENNPAAGNIR AQRRSSTVSS VTQVEVDGDT SECGSPVHTA DNIKSVKAHR
     TQSGFRKSRD KAHFSGKRKE TLV
//