ID S7PPH6_MYOBR Unreviewed; 991 AA.
AC S7PPH6;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 28-JUN-2023, entry version 36.
DE SubName: Full=Pleckstrin like proteiny domain-containing family G member 5 {ECO:0000313|EMBL:EPQ12748.1};
GN ORFNames=D623_10024036 {ECO:0000313|EMBL:EPQ12748.1};
OS Myotis brandtii (Brandt's bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ12748.1, ECO:0000313|Proteomes:UP000052978};
RN [1] {ECO:0000313|Proteomes:UP000052978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23962925; DOI=10.1038/ncomms3212;
RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA Krogh A., Wang J., Gladyshev V.N.;
RT "Genome analysis reveals insights into physiology and longevity of the
RT Brandt's bat Myotis brandtii.";
RL Nat. Commun. 4:2212-2212(2013).
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DR EMBL; KE163573; EPQ12748.1; -; Genomic_DNA.
DR AlphaFoldDB; S7PPH6; -.
DR Proteomes; UP000052978; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd13244; PH_PLEKHG5_G6; 1.
DR CDD; cd17068; RBD_PLEKHG5; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 3.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR040181; PKHG5/7.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR13217:SF11; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 5; 1.
DR PANTHER; PTHR13217; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 7; 1.
DR Pfam; PF00621; RhoGEF; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50010; DH_2; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000052978}.
FT DOMAIN 388..550
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 570..623
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 120..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 759..927
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 773..793
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 794..822
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 842..868
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 883..897
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 903..926
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 991 AA; 110927 MW; 8A78EDEA8C38BF83 CRC64;
MCLYWKKRGA YELEALPSAL AGLELGAVER FSWSSTLDII EDLGDAGSLA EEKGLRCQNP
DCMDKGRAAK VCHHADCQQL HRRGPLNLCQ ACDSKFHSAM HYDGHVRFDL PPQGSVLARN
VSTRSCPPRT SPAVDLEEEE ESSVDGKGDR KSTGLKLSKK KARRRHTDDP SKECFTLKFD
LNVDIETEIV PAVKKKALGE VLLPIFERKG IALGKVDIYL DQSNTPLSLT FEAYRFGGHY
LRVKAKPGDE GKVEQGVKDS KSLSLPILQP AGAPRFFGGN DSWKNRAASR FSGFFSSGPS
ASVFAQCQRL RPVVSFQEVD KMEQLEGKLH AYGLFGLPRL PRRLRFDHDS WEEEGDEEED
EDDACLWLED SWRDLIDGHE KLTRRQCHQQ EAVWELLHTE ASYIKKLRVI TNLFLCCLLN
LQESGLLCEK ARRTRALLQP GDLLKGFKMF GSLFKPYIRY CMEEEGCMEY MRSLLRDNDL
FRAYVTWAEK HQQCQRLKLS DMLAKPHQRL TKYPLLLKSV LRRTDEPRAK EAVITMISSV
ERFIHHVNAC MRQRQERQRL AAVVSRIDAY ELSDMLAKPH QRLTKYPLLL KLMLRKRDEP
RAKEAVITMI SSVERFIHHV NACMWQRQER QQLAAVVSCM DAYEVVEGSN DEVDKLLKEF
LHLDLTAPIP GASPEETRQL LLEGSLRMKE GKDSKMDVYC FLFTDLLLVT KAVKKAERTK
VIRPPLLVDK IVCRELRDPG EEPAPCPWAR ANQLQQLRAQ EHGGSQQHLQ SLEEEEDEQE
DEEEDEEDEE GGESSTSATS SPTILRKSSN SLDSQHCASD GSTETLAMVV LEPGETLSSP
EFEGGPFSSQ SDEMSLSTTA SSVTPTSELL ALGPGDGRSC SMDSAYGTLS PTSLQDFATP
APVVEPAPQP LDLPQAPSPP PSPCLRRRRT PVQLLPCLPH LLKSKSEATQ GVPPAPSRSL
SELCLAAALP PPPPHPCPAA ALPAPPAQVQ I
//
