ID S7PQJ4_MYOBR Unreviewed; 1919 AA.
AC S7PQJ4;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Echinoderm microtubule-associated protein-like 5 {ECO:0000313|EMBL:EPQ10737.1};
GN ORFNames=D623_10022344 {ECO:0000313|EMBL:EPQ10737.1};
OS Myotis brandtii (Brandt's bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ10737.1, ECO:0000313|Proteomes:UP000052978};
RN [1] {ECO:0000313|Proteomes:UP000052978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23962925; DOI=10.1038/ncomms3212;
RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA Krogh A., Wang J., Gladyshev V.N.;
RT "Genome analysis reveals insights into physiology and longevity of the
RT Brandt's bat Myotis brandtii.";
RL Nat. Commun. 4:2212-2212(2013).
CC -!- FUNCTION: May modify the assembly dynamics of microtubules, such that
CC microtubules are slightly longer, but more dynamic.
CC {ECO:0000256|ARBA:ARBA00003210}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the WD repeat EMAP family.
CC {ECO:0000256|ARBA:ARBA00006489}.
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DR EMBL; KE163073; EPQ10737.1; -; Genomic_DNA.
DR eggNOG; KOG2106; Eukaryota.
DR Proteomes; UP000052978; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 6.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR005108; HELP.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13720:SF16; ECHINODERM MICROTUBULE-ASSOCIATED PROTEIN-LIKE 5; 1.
DR PANTHER; PTHR13720; WD-40 REPEAT PROTEIN; 1.
DR Pfam; PF12894; ANAPC4_WD40; 2.
DR Pfam; PF03451; HELP; 2.
DR Pfam; PF00400; WD40; 10.
DR SMART; SM00320; WD40; 27.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 2.
DR SUPFAM; SSF50978; WD40 repeat-like; 5.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000052978};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 178..209
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 275..307
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 326..405
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT DOMAIN 610..660
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 844..874
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1179..1211
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1293..1352
FT /note="HELP"
FT /evidence="ECO:0000259|Pfam:PF03451"
FT REPEAT 1647..1681
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1691..1771
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
FT REPEAT 1880..1913
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 554..578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 597..617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1215..1244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1285..1305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 560..577
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1919 AA; 213659 MW; 15A97C37C03359D8 CRC64;
MDAFASTIWS ILALHPERVL VATGQVGKEP YICVWDSYTV QTISVLKDVH THGIACLAFD
LDGQRLVSVG LDSKNAVCVW DWKRGKMLSM APGHTDRIFD ISWDLYQPNK LVSCGVKHIK
FWSLCGNALT PKRGVFGKTG DLQTILCLAC ARDELTYSGA LNGDIYVWKG INLIRTIQGA
HTAGIFSMNA CEEGFATGGR DGCIRLWDLT FKPITVIDLR ETDQGYKGLS VRSVCWRGDH
ILVGTQDSEI FEIVVHERKK PFLIMQGHCE GELWALAIHP TKPLAVTGSD DRSVRIWSLV
DHALIARCNM EEPIRCAAVN VDGIHLALGM KDGSFTVLRV RDMTEVVHIK DRKEAIHELK
YSPDGTYLAV GCNDSSVDIY GVSQRYKKMG ECVGSLSFIT HLDWSSDSRY LQTNDGNGKR
LFYRMPGGKE VTNKDETKGV HWASWTCVSG LEVNGIWPKY SDINDINSVD GNYIGQVLVT
ADDYGIVKLF RYPCLRKGAK FRKYIGHSAH VTNVRWSHDH QWVISIGGAD HAVFQWRFIP
ERKLKDALHI APQESLADSN SDESDSDLSD VPELDSEIEQ ETQLTYRRQV YKEDLPQLKE
QYKEKQKSGT SKRRERAPGN SIRLHFVHGY RGYDCRSNLF YTQIGEIVYH VAAVGVIYNR
QQNTQRFYLG HDDDILCLAI HPVKDYVATG QVGRDPSIHI WDTETIKPLS ILKGYHQYGV
CAVDFSADGK RLASVGIDEN HTVVLWDWKK GEKLSIARGS KDKIFVVKMN PYVPDKLITA
GIKHMKFWRR AGGGLVGRKG YIGTLGKNET MMCAVYGWTE EMAFSGTSTG DVCIWRDIFL
VKTVKAHDGP VFSMHALEKG FVTGGKDGVV ALWDDSFERC LKTYAIKRAA LAPGSKGLLL
EDNPSIRAIS LGHGHILVGT KNGEILEVDK SGPITLLVQG HMEGEVWGLA THPYLPICAT
VSDDKTLRIW DLSPSHCMLA VRKLKKGGRC CCFSPDGKAL AVGLCDGSFL MANADTLEDL
VSFHHRKDII SDIRFSPGSG KYLAVASHDS FVDIYNVMSS KRVGICKGAT SYITHIDWDI
RGKLLQVNTG AKEQLFFEAP RGKRQTIPRM EVEKIGWASW TSVLGLCCEG IWPVIGEVTD
ITASCLTHDK MVLATGDDLG FVKLFRYPAK GKFAKFKRYV AHSTQVTNVR WTCDDSMLVT
LGGADMSLMV WTNEMEGSRE KRPCDSEESD TGSEEDGGYD SDVTRENEIS YTIRALSTNI
RPMFGIKPHL QQKEPSIDER QGIVRPPVSR APPQPEKLQT NNVGKKKRPI EDLMLELVFG
YRGRDCRNNV HYLNDGDDII YHTASIGILH NVATGTQSFY QEHNDDILCL TVNQHPKFIN
IVATGQVGDS ADMSPTAPSV HVWDAVNKQT LAILRCYHSK GVCSVSFSAT GKLLLSVGLD
PEHTVTIWRW QEGAKIASKA GHNQRIFVAE FRPDSDSQFV SVGVKHVKFW TLAGRALLSK
KGLLSTLEDA RMQTMLAVAF GANNLTFTGT ISGDVCVWKD HILCRVVARA HNGPVFAMYT
TLRDGLIVTG GKERPSKEGG AVKLWDQELR RCRAFRLETG QVTDCVRSVC RGRGKILVGT
RNAEIIEVGE KNAACNILVN GHVDGPIWGL ATHPSRDFFL SAAEDGTVRL WDIADKKMLN
KVNLGHAART VCYSPEGDMV AIGMKNGEFI ILLVSSLKIW GKKRDRRCAI HDIRFSPDCR
FLAVGSSENS VDFYDLSLGP TLNRTSYCKD IPSFVIQMDF SADSRYLQVS TGCYKRHVYE
VPSGRHLTDQ AAIDRITWAT WTSILGSEVM GIWSRHAEKA DVNCACVSHS GISLVTGDDF
GMVKLFDFPC PEKFAKHKRF LGHSPHVTNI RFTSGDRHVI SAGGDDCSLF VWKCVHTPH
//
