ID S7Q3W8_MYOBR Unreviewed; 652 AA.
AC S7Q3W8;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Double-stranded RNA-specific editase 1 {ECO:0000313|EMBL:EPQ15582.1};
GN ORFNames=D623_10014961 {ECO:0000313|EMBL:EPQ15582.1};
OS Myotis brandtii (Brandt's bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ15582.1, ECO:0000313|Proteomes:UP000052978};
RN [1] {ECO:0000313|Proteomes:UP000052978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23962925; DOI=10.1038/ncomms3212;
RA Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA Krogh A., Wang J., Gladyshev V.N.;
RT "Genome analysis reveals insights into physiology and longevity of the
RT Brandt's bat Myotis brandtii.";
RL Nat. Commun. 4:2212-2212(2013).
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DR EMBL; KE164160; EPQ15582.1; -; Genomic_DNA.
DR AlphaFoldDB; S7Q3W8; -.
DR eggNOG; KOG2777; Eukaryota.
DR Proteomes; UP000052978; Unassembled WGS sequence.
DR GO; GO:0004000; F:adenosine deaminase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd19895; DSRM_RED1_rpt1; 1.
DR CDD; cd19898; DSRM_RED1_rpt2; 1.
DR Gene3D; 3.30.160.20; -; 2.
DR InterPro; IPR002466; A_deamin.
DR InterPro; IPR044458; ADAR2_DSRM_1.
DR InterPro; IPR044459; ADAR2_DSRM_2.
DR InterPro; IPR014720; dsRBD_dom.
DR PANTHER; PTHR10910:SF58; DOUBLE-STRANDED RNA-SPECIFIC EDITASE 1; 1.
DR PANTHER; PTHR10910; EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN; 1.
DR Pfam; PF02137; A_deamin; 1.
DR Pfam; PF00035; dsrm; 2.
DR SMART; SM00552; ADEAMc; 1.
DR SMART; SM00358; DSRM; 2.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 2.
DR PROSITE; PS50141; A_DEAMIN_EDITASE; 1.
DR PROSITE; PS50137; DS_RBD; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000052978};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266}.
FT DOMAIN 126..192
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 298..347
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 419..630
FT /note="A to I editase"
FT /evidence="ECO:0000259|PROSITE:PS50141"
FT REGION 1..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..33
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 652 AA; 71389 MW; DB4BF7F765742E6D CRC64;
MASPVTGTLT MGTFFSIMGR RYKRRRRKRS ERKDRNSLRQ SRNPPKYFAM DLEDEENLSS
SSTEAKDSCS VDPGPPGDSA PGPADSYLLP NGGGGSVGRK RPLDEGSNGH AKFRLKKRRR
APGPALPKNA LMQLNEIKPG LQYTLLSQTG PVHAPLFVIS VEVNGQVFEG SGPTKKKAKL
QAAEKALRSF VQFPNASEAH LAMGRSLSAN TDFTSDQADF PDALFNGFET PDRSEVPFYM
GSNGGDDSFS SSGDLSLSAS PVPPNLVQPP LPVLPPFPPP AGKNPVMILN ELRPGLKYDF
LSESGESHAK NFVMSVVVDG QFFEGSGRNK KLAKARAAQS ALATIFNLHL DQTPSRQPIL
SEGLQLHLPQ VLADAVARLV LDKFGDLTDN FTSPHARRKV LAGIVMTTGT DVKDAQVICV
STGTKCINGE YMSDRGLALN DCHAEIISRR SLLRFLYTQL ELYLNKEDQK KSIFQKSERG
GFRLKDTVQF HLYISTSPCG DARIFSPHEP ILEEPADRHP NRKARGQLRT KIESGEGTIP
VRSNASIQTW DGVLQGERLL TMSCSDKMAR WNVVGIQGSL LSIFVEPIYF SSIILGSLYH
GDHLSRAMYQ RISNIEDLPP LYTLNKPLLS GKYPIVTSPL PDKLMCSAAS CG
//
