ID   S7QAW2_MYOBR            Unreviewed;       705 AA.
AC   S7QAW2;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Klotho {ECO:0000313|EMBL:EPQ18247.1};
GN   ORFNames=D623_10026619 {ECO:0000313|EMBL:EPQ18247.1};
OS   Myotis brandtii (Brandt's bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC   Myotis.
OX   NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ18247.1, ECO:0000313|Proteomes:UP000052978};
RN   [1] {ECO:0000313|Proteomes:UP000052978}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23962925; DOI=10.1038/ncomms3212;
RA   Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA   Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D., Hee Yim S.,
RA   Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N., Chen G., Kulakova O.I.,
RA   Sun Y., Lee S.G., Bronson R.T., Moskalev A.A., Sunyaev S.R., Zhang G.,
RA   Krogh A., Wang J., Gladyshev V.N.;
RT   "Genome analysis reveals insights into physiology and longevity of the
RT   Brandt's bat Myotis brandtii.";
RL   Nat. Commun. 4:2212-2212(2013).
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 1 family.
CC       {ECO:0000256|RuleBase:RU003690}.
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DR   EMBL; KE164498; EPQ18247.1; -; Genomic_DNA.
DR   AlphaFoldDB; S7QAW2; -.
DR   eggNOG; KOG0626; Eukaryota.
DR   Proteomes; UP000052978; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 3.20.20.80; Glycosidases; 2.
DR   InterPro; IPR001360; Glyco_hydro_1.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR10353; GLYCOSYL HYDROLASE; 1.
DR   PANTHER; PTHR10353:SF10; KLOTHO; 1.
DR   Pfam; PF00232; Glyco_hydro_1; 3.
DR   PRINTS; PR00131; GLHYDRLASE1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 2.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000052978};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        675..696
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   705 AA;  82190 MW;  69787438F7004C8B CRC64;
     MTDHNIKECQ KSLDFVLGWF AKPIFIDGDY PESMKNNLSS LLPAFTEPEK KFIKGTADFF
     ALSFGPTLSF QLLDPRMKFR QLESPSLRQL LSWIDLEYNH PQIFIVENSW FVSGTTKRDD
     AKYMYYLKTF IMETLKAIRL DGVNIIGYTA WSLMDGFEWH RGYSIRRGLF YVDFLSQDKK
     LLPKSSALFY QQLIEKNGFP PLPENQPLEG TFPCDFAWGI VDNYIQVDTT LSQFTDPNVY
     LWDVHHSKRL IKVDGLVTKR RKPYCVDFTV IRLQIALLQE MRVTHFHFSL DWALILPLGD
     QSQVNRTVLH YYRCVASELR HANITPVVAL WRPVFPHQGL PEPLAKQGAW ENPQTALAFA
     EYARLCFKDL GSHVKFWITM NEPYTRNMTY SAGHNLLKAH ALAWRLYDEK FRRSQKGKIS
     IALQADWIEP ACPFSPKDKE VAERVLEFDI GWLAEPIFGS GDYPRVMRDW LNHRNNFLLP
     YFTEDEKKLI QGSFDFLAVS HYTTILVDWE KEDPIKYNDY LEVQEMTDIT WLNSPSQVAV
     VPWGLRKVLS WLKLKYGDLP MYIISNGIDD DLQAGQDKLR VYYMQNYVNE ALKAYILDGI
     NLCGYFVFSF NDRTAPKFGL YRYAANQFEP KPSMQHYRKI IDNNGFPGAE TLGRFCSEEF
     TLCTECSFFH TRKTLLAFIA FLLFALIISL SLIFHYSKKG RGNYK
//