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Database: UniProt
Entry: S7QFA4_MYOBR
LinkDB: S7QFA4_MYOBR
Original site: S7QFA4_MYOBR 
ID   S7QFA4_MYOBR            Unreviewed;      4902 AA.
AC   S7QFA4;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   10-MAY-2017, entry version 20.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|EMBL:EPQ19932.1};
GN   ORFNames=D623_10022168 {ECO:0000313|EMBL:EPQ19932.1};
OS   Myotis brandtii (Brandt's bat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera;
OC   Vespertilionidae; Myotis.
OX   NCBI_TaxID=109478 {ECO:0000313|EMBL:EPQ19932.1, ECO:0000313|Proteomes:UP000052978};
RN   [1] {ECO:0000313|Proteomes:UP000052978}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23962925; DOI=10.1038/ncomms3212;
RA   Seim I., Fang X., Xiong Z., Lobanov A.V., Huang Z., Ma S., Feng Y.,
RA   Turanov A.A., Zhu Y., Lenz T.L., Gerashchenko M.V., Fan D.,
RA   Hee Yim S., Yao X., Jordan D., Xiong Y., Ma Y., Lyapunov A.N.,
RA   Chen G., Kulakova O.I., Sun Y., Lee S.G., Bronson R.T., Moskalev A.A.,
RA   Sunyaev S.R., Zhang G., Krogh A., Wang J., Gladyshev V.N.;
RT   "Genome analysis reveals insights into physiology and longevity of the
RT   Brandt's bat Myotis brandtii.";
RL   Nat. Commun. 4:2212-2212(2013).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; KE164757; EPQ19932.1; -; Genomic_DNA.
DR   Proteomes; UP000052978; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 3.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000052978};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:EPQ19932.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000052978};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4227   4251       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4454   4474       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4524   4548       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4653   4671       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4714   4735       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4794   4817       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       87    142       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      149    194       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      202    256       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      262    320       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      330    387       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      572    783       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      999   1195       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1241   1453       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3962   3997       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   4902 AA;  555015 MW;  C80241163BD8D896 CRC64;
     MEELEDEVVL QCIANIHKEQ RKFCLAAEGL GNRLCFLEPT SEAKYVPPDL CVCNFVLEQS
     LSVRALQEML ANTGENGGEG AAQGGGHRTL LYGHAILLRH SFSGMYLTCL TTSRSQTDKL
     AFDVGLREHA TGEACWWTIH PASKQRSEGE KVRIGDDLIL VSVSSERYLH LSISNANIQV
     DASFMQTLWN VHPTCSGSSI EEGYLLGGHV VRLFHGHDEC LTIPSTDQND SQHRRIFYEA
     GGAGTRARSL WRVEPLRISW SGSNIRWGQA FRLRHLTTGH YLALTEDQGL LLQDRVKSDT
     KSTAFSFRAS KEIKEKLDSS HKRDIEGMGV PEIKYGDSVC FVQHVASGLW VTYKAQDAKT
     SRLGPLKRKV ILHQEGHMDD GLTLQRCQRE ESQAARIIRN TTALFSQFVS GNNRTAAPVT
     LPIEEVLQTL RDLIAYFQPP EEEMQHEDKQ NKLRSLKNRQ NLFKEEGMLA LVLTCIDRLN
     IYNSVAHFAG IAREESGMAW KEILNLLYKL LAALIRGNRN NCAQFSNNLD WLISKLDRLE
     SSSGILEVLH CILIESPEAL NLIAEGHIKS IISLLDKHGR NHKVLDVLCS LCLCNGVAVR
     ANQNLICDNL LPRRNLLLQT RLINDVTSIR PNIFLGVAEG SAQYKKWYFE LIIDQVDPFL
     TPEPTHLRVG WASSSGYAPY PGGGEGWGGN GVGDDLYSYG FDGLHLWSGR IPRAVASINQ
     HLLKSDDVVS CCLDLGVPSI SFRINGQPVQ GMFENFNTDG LFFPVVSFSA GVKVRFLMGG
     RHGEFKFLPP SGYAPCYEAL LPKEKMRLEP VKEYKRDSEG IRDLLGTTQF LSQASFTPCP
     IDTSQVVLPP HLEKIRDRLA ENIHELWGMN KIELGWTFGK IRDDNKRQHP CLVEFSKLPE
     TEKNYNLQMS TETLKTLLAL GCHIAHVNPA AEEDLKKVKL SKNYIMSNGY KPAPLDLSDV
     KLLPSQEILV DKLAENAHNV WAKDRIKQGW TYGIQQDLKN KRNPRLVPYA LLDERTKKSN
     RDSLREAVRT FVGYGYNIEP SDQELADPAV EKVSIDKIRF FRVERSYAVR SGKWYFEFEV
     VTGGDMRVGW ARPGCRPDIE LGADDQAFVF EGSRGQRWHQ GSGYFGRTWQ PGDVVGCMIN
     LDDASMIFTL NGELLITNKG SELAFADYEI ENGFVPICSL GLSQIGRMNL GMDASTFKFY
     TMCGLQEGFE PFAVNMNRDV AMWFSKRLPT FVNVPKDHPQ IEVMRIDSTM DSPPCLKVTH
     KTFGTQNSDA SMIYLRLSMP VECHSSFTHS PCLDSDAFQK RKQMQELLSQ TTTQCYYAIR
     IFAGQDPSCV WVGWVTPDYH FYSEKFDLNK NCTVTVTLGD ERGRVHESVK RSNCYMVWGG
     DIVATSQRSS RSNVDLEIGC LVDLAMGMLS FSANGRELGT CYQVEPNTKV FPAVFLQPTS
     TSLFQFELGK LKTALPLSAA IFKSEEKNPA PQCPPRLDVQ TIQPVLWSRM PSSFLKVETE
     RVSERHGWVV QCPEPLQMMA LHIPEESRCV DILELCEQED LMQFHYHTLR LYSAVCALGN
     SRVAYALCSH VDLSQLFYAI DNKYLPGLLR SGFYDLLISI HLANAKERKL MMKNEYIIPI
     NSTTRKIRLY PDKSKRHGLP GVGLRTCLKP GFKFSTPCVV MTSEEHQKQS PEIPLDILKT
     KALSMLTEAV QGSGAHIRDP VGGSVEFQFV PVLKLIGTLL VMGVFDDDDV RQILLLIDPS
     VFGEHSGETE EGAEKEEVTQ VEEKAVEAGE KASKEAPVKG LLQTRLPESV KLQMCELLSY
     LCDCELQHRV EAIVAFGDIY VSKLQANQKF RYNELMQALN MSAALTARKT KEFRSPPQEQ
     INMLLNFQLG ENCPCPDEIR EELYDFHEDL LTHCGVPLEG EEEEEEDSSW TGKLRALLQK
     IKGPPKPEKH QPAVEEERCP TTLKELISQT MIRWAQEDQI QDADLIRMMF NLLRRQYDSI
     GELLQALRKT YTISQASVSD TINLLAALGQ IRCLLSVRMG KEEELLMING LGDIMNNKVF
     YQHPNLMRVL GMHETELISQ TMIRWAQEDQ IQDADLIRMM FNLLRRQYDS IGELLQALRK
     TYTISQASVS DTINLLAALG QIRCLLSVRM GKEEELLMIN GLGDIMNNKV FYQHPNLMRV
     LGMHETVMEV MVNVLGAEKS QIAFPKMVAS CCRFLCYFCR ISRQNQKAMF EHLSYLLENS
     SVGLASPSMR GSTPLDVAAS SVMDNNELAL GLEEPDLEKV VTYLAGCGLQ SCPMLLAKGY
     PDVGWNPIEG ERYLSFLRFA VFVNSESVEE NASVVVKLLI RRPECFGPAL RGEGGNGLLA
     AMQGAIKISE NPALDLPSQG YKREVTEDSE DEEEIVHMGN AIMSFYSALI DLLGRCAPEM
     HLIQTGKGEA IRIRSILRSL VPTEDLVGII SIPLKLPSLN KDGSVSEPDM AASFCPDHKA
     SMVLFLDRVY GIKDQTFLLH LLEVGFLPDL RASASLDTVS LSTTEAALAL NRYICSAVLP
     LLTRCAPLFA GTEHYTSLID STLQTIYRLS KGRSLTKAQR DTIEECLLAI CNHLRPSMLQ
     QLLRRLVFDV PQLNEYCKMP LKLLTSHYEQ CWKYYCLPSG WGSYGLAVEE ELHLTEKLFW
     GIFDSLSHKK YDPDLFRMAL PCLSAIAGAL PPDYLDTRIS ATLEKQISVD ADGNFDPKPI
     NTVNFSLPEK LEHIVTKYAE HSHDKWACDK SQSGWKYGIS LDENVKTHPL IRPFKTLTEK
     EKEIYRWPAR ESLKTMLAVG WTVERTKEAE ALVQQRENEK LRSMSQASQG NSYSPAPLDL
     CNVALSRELQ GMVEVIAENY HNIWAKKKKL ELESKGGGSH PLLVPYDTLT AKEKSRDREK
     AQDLFKFLQV NGIVVSRGMK DMELDASSME KRFAYKFLKK ILKYVDSAQE FIAHLEAIVI
     SGKTERSPHD QEIKFFAKVL LPLVDQYFTN HRLYFLSSPL KPLSSSGFAS HKEKEMVASL
     FCKLAALVRH RISLFGSDST TMVSCLHILA QTLDTRTVMK SGSELVKAGL RAFFENAAED
     LEKTSENLKL GKFTHSRTQI KGVSQNINYT TVALLPILTS IFEHVAQHQF GVDLLLGDVQ
     ISCYHILCSL YSLGTGKNIY VERQRPALGE CLASLAAAIP VAFLEPTLNR YNPLSVFNTK
     TPRERSILGV PDTVEEMCPD IPPLERLMKE IHHLAESGAR YTEMPHVIEV ILPMLCNYLS
     YWWEQGPEHL PPSTGPWCTK VTSEHLSVIL GNILKIINNN LGIDEASWMK RIAVYAQPII
     SKARPDLLRS HFIPTLEKLK KKAVKTVQEE EQLKADSKGD TQEAELLILD EFAVLCRDLY
     AFYPMLIRYV DNNRSNWLKS PDADSDQLFR MVAEVFILWC KSHNFKREEQ NFVIQNEINN
     LAFLTGDSKS KMSKSGGQDQ ERKKTKRRGD LYSIQTSLIV AALKKMLPIG LNMCTPGDQE
     LISLAKSRYS CRDTDEEVKE HLRNNLHLQE KSDDPAVKWQ LNLYKDVLKS EEPSNPEKTV
     ERVQRISAAV FHLEQVEQPL RSKKAVWHKL LSKQRKRAVV ACFRMAPLYN LPRQVFCHLL
     YCEPVVGIKK SPRAEEEEEA EAEKQPDPLH QIILHFSRNA LTERSKLEDD PLYTSYSSMM
     AKSCQNGEDE EEEEDKEKTF EEKEMEKQKT LYQQARLHER GAAEMVLQMI SASKGERSPM
     VVETLKLGIA ILNGGNAGVQ QKMLDYLKEK KDAGFFQSLS GLMQSCSVLD LNAFERQNKA
     EGLGMVTEEG THFQNFLRTQ MGNTTTVNII ISTVDYLLRL QESISDFYWY YSGKDIIDES
     GQHNFSKALV VTKQIFNSLT EYIQGPCIGN QQSLAHSRLW DAVVGFLHVF ANMQMKLSQD
     SSQIELLKEL LDLLQDMVVM LLSLLEGNVV NGTIGKQMVD TLVESSTNVE MILKFFDMFL
     KLKDLTSSDT FKEYDPDGKG IISKKEFQKA MEGQKQYTQS EIDFLLSCAE ADENDMFNYI
     DFVDRFHEPA KDIGFNVAVL LTNLSEHMPN DSRLKCLLDP AESVLNYFEP YLGRIEIMGG
     AKKIERVYFE ISESSRTQWE KPQVKESKRQ FIFDVVNEGG EQEKMELFVN FCEDTIFEMQ
     LASQISESDS TDRPEEEEEE DEDSSYTLEI EGEEEDDKSF ESVSAFAMAC ASVKRNVANF
     LKRVTLKNLR KQYRKVKKMT VKELVKVFFS FFWMLFVGLF QLFFTILGGI FQILWNTVFG
     GGLVEGAKNI RVTKILGDMP DPTQFGIHDD VLEAERAEVT ETGITTELVH FLKGEKGDAD
     IMSDLFGFHS KKEGGSKHGP EVGLGDLSEI IGKDEPPTLE STVRKKRKVQ AAEMKAAHDS
     EGKVEPEKAD MEDGEKEETA GEEQAKVLWA EATKKKKRRR GQKVEKPEAF MANFFKGLEI
     YQTKLLHYLA RNFYNLRFLA LFVAFAINFI LLFYKVTEEP LEEEAEDVVN LWHSFSDDEE
     EEAMVFFVLQ ESTGYMAPTL RALAVIHTII SLVCVVGYCC LKVPLVVFKR EKEIARKLEF
     DGLYITEQPS EDDIKGQWDR LVINTPSFPN NYWDKFVKRK VINKYGDLYG AERIAELLGL
     DKNALDFSPV EETKAEAASL VSWLSSIDMK YHIWKLGVVF TDNSFLYLAW YTTMSILGHY
     NNFFFAAHLL DIAMGFKTLR TILSSVTHNG KQLVLTVGLL AVVVYLYTVV AFNFFRKFYN
     KSEDDDEPDM KCDDMMTCYL FHMYVGVRAG GGIGDEIEDP AGDPYEMYRI VFDITFFFFV
     IVILLAIIQG LIIDAFGELR DQQEQVREDM ETKCFICGIG NDYFDTTPHG FETHTLQEHN
     LANYLFFLMY LINKDETEHT GQQQHFAVLE TSATSPPFLS LR
//
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