ID S7QK59_GLOTA Unreviewed; 732 AA.
AC S7QK59;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Ras GEF {ECO:0000313|EMBL:EPQ60126.1};
GN ORFNames=GLOTRDRAFT_112874 {ECO:0000313|EMBL:EPQ60126.1};
OS Gloeophyllum trabeum (strain ATCC 11539 / FP-39264 / Madison 617) (Brown
OS rot fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Gloeophyllales; Gloeophyllaceae; Gloeophyllum.
OX NCBI_TaxID=670483 {ECO:0000313|EMBL:EPQ60126.1, ECO:0000313|Proteomes:UP000030669};
RN [1] {ECO:0000313|EMBL:EPQ60126.1, ECO:0000313|Proteomes:UP000030669}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11539 {ECO:0000313|EMBL:EPQ60126.1,
RC ECO:0000313|Proteomes:UP000030669};
RX PubMed=22745431; DOI=10.1126/science.1221748;
RA Floudas D., Binder M., Riley R., Barry K., Blanchette R.A., Henrissat B.,
RA Martinez A.T., Otillar R., Spatafora J.W., Yadav J.S., Aerts A., Benoit I.,
RA Boyd A., Carlson A., Copeland A., Coutinho P.M., de Vries R.P.,
RA Ferreira P., Findley K., Foster B., Gaskell J., Glotzer D., Gorecki P.,
RA Heitman J., Hesse C., Hori C., Igarashi K., Jurgens J.A., Kallen N.,
RA Kersten P., Kohler A., Kuees U., Kumar T.K.A., Kuo A., LaButti K.,
RA Larrondo L.F., Lindquist E., Ling A., Lombard V., Lucas S., Lundell T.,
RA Martin R., McLaughlin D.J., Morgenstern I., Morin E., Murat C., Nagy L.G.,
RA Nolan M., Ohm R.A., Patyshakuliyeva A., Rokas A., Ruiz-Duenas F.J.,
RA Sabat G., Salamov A., Samejima M., Schmutz J., Slot J.C., St John F.,
RA Stenlid J., Sun H., Sun S., Syed K., Tsang A., Wiebenga A., Young D.,
RA Pisabarro A., Eastwood D.C., Martin F., Cullen D., Grigoriev I.V.,
RA Hibbett D.S.;
RT "The Paleozoic origin of enzymatic lignin decomposition reconstructed from
RT 31 fungal genomes.";
RL Science 336:1715-1719(2012).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB469296; EPQ60126.1; -; Genomic_DNA.
DR RefSeq; XP_007860602.1; XM_007862411.1.
DR AlphaFoldDB; S7QK59; -.
DR STRING; 670483.S7QK59; -.
DR GeneID; 19299634; -.
DR KEGG; gtr:GLOTRDRAFT_112874; -.
DR eggNOG; KOG3417; Eukaryota.
DR HOGENOM; CLU_002632_1_1_1; -.
DR OMA; TGWWAAM; -.
DR OrthoDB; 1654263at2759; -.
DR Proteomes; UP000030669; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000030669};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 42..103
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 331..465
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 480..716
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 134..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 134..168
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..221
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 732 AA; 82112 MW; CF10714C4F066985 CRC64;
MTRRACADRS SAWQIYHRRR SGQPTSSSPA LPLPSTTTAG EFKIFSVLCL YDFHSDDPDH
LPFRKSEILD VVKTEESGWW AAMRPAHTQV GWVPSAFVRP LTDEMAERLR GLREELRIYD
YEAERLYNAA PTSNFAQLYP PDADSQSDEN PPSRSFPRPS SSAAARTPSA PSRPCAPRPR
PPPTPPTSPM PTCTPPRPTR PPSACAPRPH PSRPCPSRPP SRPKPRPRRR PRGRLAPPGE
GGRLLPDDRS SLSRLSVLVE RSNVAEPDDL SAGEAEELLG GARPHKGRPD KVKQLTGDED
AQRYHNAKVA ALRMPWYLKP DYKEEDVKLN ADGSVLAGTL EALVECLTIE PISKNQDMLY
QNTFLMTFRT FASADRVFDL LVDRYQMDRS FGLTDAQFAE WKEKKLRPTQ KRVLVVLGRW
LEEHRMPADD AHVVPRLQEF LSLIVEPPAL ATTAKLMIAS LERLKRPGRS SHRTELLKMD
PTEVAQQLCV LEYNLYSKIR PQECLDWTKT QMGRTVENLH AFCATYDKLA AWVKTSILDT
DVLGKRADTV EFWIRVAEKS RTFNNLSSFS ALVAALSSAA ISRLHLTMAH VSRSSHLDAL
TKVIEPTGNF AAYRAVLQTV DGPCVPWVGM YLSDLVHIGD QHPDTLKGPA LDRPLINFYK
RQKWADTVSA MLRFQGRPYP FAPDAAILGF IETNLQKAAG KDHSTFWLKS QEVQQSELAH
ADIRKGLEAA GF
//
