ID S7RX58_GLOTA Unreviewed; 1152 AA.
AC S7RX58;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=Insulin-degrading enzyme {ECO:0008006|Google:ProtNLM};
GN ORFNames=GLOTRDRAFT_119876 {ECO:0000313|EMBL:EPQ57929.1};
OS Gloeophyllum trabeum (strain ATCC 11539 / FP-39264 / Madison 617) (Brown
OS rot fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Gloeophyllales; Gloeophyllaceae; Gloeophyllum.
OX NCBI_TaxID=670483 {ECO:0000313|EMBL:EPQ57929.1, ECO:0000313|Proteomes:UP000030669};
RN [1] {ECO:0000313|EMBL:EPQ57929.1, ECO:0000313|Proteomes:UP000030669}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11539 {ECO:0000313|EMBL:EPQ57929.1,
RC ECO:0000313|Proteomes:UP000030669};
RX PubMed=22745431; DOI=10.1126/science.1221748;
RA Floudas D., Binder M., Riley R., Barry K., Blanchette R.A., Henrissat B.,
RA Martinez A.T., Otillar R., Spatafora J.W., Yadav J.S., Aerts A., Benoit I.,
RA Boyd A., Carlson A., Copeland A., Coutinho P.M., de Vries R.P.,
RA Ferreira P., Findley K., Foster B., Gaskell J., Glotzer D., Gorecki P.,
RA Heitman J., Hesse C., Hori C., Igarashi K., Jurgens J.A., Kallen N.,
RA Kersten P., Kohler A., Kuees U., Kumar T.K.A., Kuo A., LaButti K.,
RA Larrondo L.F., Lindquist E., Ling A., Lombard V., Lucas S., Lundell T.,
RA Martin R., McLaughlin D.J., Morgenstern I., Morin E., Murat C., Nagy L.G.,
RA Nolan M., Ohm R.A., Patyshakuliyeva A., Rokas A., Ruiz-Duenas F.J.,
RA Sabat G., Salamov A., Samejima M., Schmutz J., Slot J.C., St John F.,
RA Stenlid J., Sun H., Sun S., Syed K., Tsang A., Wiebenga A., Young D.,
RA Pisabarro A., Eastwood D.C., Martin F., Cullen D., Grigoriev I.V.,
RA Hibbett D.S.;
RT "The Paleozoic origin of enzymatic lignin decomposition reconstructed from
RT 31 fungal genomes.";
RL Science 336:1715-1719(2012).
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
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DR EMBL; KB469298; EPQ57929.1; -; Genomic_DNA.
DR RefSeq; XP_007863251.1; XM_007865060.1.
DR AlphaFoldDB; S7RX58; -.
DR STRING; 670483.S7RX58; -.
DR MEROPS; M16.008; -.
DR GeneID; 19300590; -.
DR KEGG; gtr:GLOTRDRAFT_119876; -.
DR eggNOG; KOG0959; Eukaryota.
DR HOGENOM; CLU_004639_1_2_1; -.
DR OMA; WIFDEMK; -.
DR OrthoDB; 129328at2759; -.
DR Proteomes; UP000030669; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR001431; Pept_M16_Zn_BS.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR032632; Peptidase_M16_M.
DR PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR Pfam; PF16187; Peptidase_M16_M; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 5.
DR PROSITE; PS00143; INSULINASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000030669};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 49..183
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 270..444
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT DOMAIN 456..760
FT /note="Peptidase M16 middle/third"
FT /evidence="ECO:0000259|Pfam:PF16187"
FT DOMAIN 765..948
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT REGION 208..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1127..1152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..240
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1152 AA; 129970 MW; 777E3F4B4EE1850A CRC64;
MVDHANWRHV PASGTRPPYR VFTKPIDKSQ QDDREYRIIE LQNGLQATVI HDAKADKAAA
SLDVAVGHLY DPDDMPGLAH FCEHLLFMGT EQFPRENEYS EYLSKNAGSS NAYTATSNTN
YYFNVSTPAL AGALARFAAF FHCPLFAPSC TSRELNAVDS EHKKNHQSDM WRIFQLNKHL
SKPGHVWRKF GSGNRESLSQ VAKELKQKGL LNGTNGKNTN SIKVNGNGSA SARSSLAPSP
VPSRLPSPAP SEASANSELE ADGGAIGRET RRRLVEWWSK EYCAGRMRLC VIGKESLDEL
CELVATLFSP IPNRGQESLP MINDHPFGSE EKGTLVAVQT IMDFHVLEIS FPLAYQPPFW
RYKPANFLAH FVGHEGPGSL HSYLKNKGWI TSLSAGAQNL ARGFGMFKVT VHMTQDGFQN
YRSIMLATYK YLNMLRSSEL PAWHSREIST IASIRFRFAE KRRPDDYAVW VAEHMAWPVP
RELVISAPQL TWPWDEPGAQ KDANGSWIGE KEVREILNGL KVDNGRAVLM ARQAEHEKVA
GNGVALDWQT EPWYGTGYRV VRLDEQFTRE AQSPNQLQEL FLPGPNEFIP TNLDVDKRDV
AEPLEHPHLI RDTPLSTLWF KKDDRFWVPK ARVAIDVRSP LANPTPRSVV MTKLFGRLVT
DSLTEYTYDA DLAGLSYDVI THGLGIWVIV SGYNDKVPVL TRRVFEAIKH LTIVPERLEV
FKEQVKREWQ NFFLGQSYGM SDYFGRYLLT ERQWTLQEML PEIASVTADE VQSHAKQLLS
EVNMRMLVTG NVHKEDAVHI AELAESILKS SPLPASSVIE RSLILPEASN HVWSIPVPNP
NQTNSALTYY LHVGDLTDEQ LRVISSLLAQ ILSEPAFNVL RTQEQLGYIV SCSQWHLAGD
SQKGLRIVIQ SERPPHYLES RVNAFLNNMR RAIEEMSEEE FAEQKQGLER KWTEKPKNLS
EETNRFWMHI DSGYYDFLRR FRNAELLRSV TKQDVLDLFD SRIHPSAPKR AKLSVHLRSQ
KPPPKKVSLA AMAAFEDLVR SAGMPVEKDA WKEEFDGSEG EPLLADFTKH WQGILASEST
TAGLSEEITK NLLASIPKVV EQHPAQVSEE TSTDVLEGVT FIKDPKTFKS SLQPSPDPRP
AGEWKDTTAA KL
//
