ID S7UAU2_9BACI Unreviewed; 72 AA.
AC S7UAU2;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Thymidine kinase {ECO:0000256|ARBA:ARBA00012118, ECO:0000256|RuleBase:RU000544};
DE EC=2.7.1.21 {ECO:0000256|ARBA:ARBA00012118, ECO:0000256|RuleBase:RU000544};
DE Flags: Fragment;
GN ORFNames=I656_00998 {ECO:0000313|EMBL:EPR29363.1};
OS Geobacillus sp. WSUCF1.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Geobacillus.
OX NCBI_TaxID=886559 {ECO:0000313|EMBL:EPR29363.1, ECO:0000313|Proteomes:UP000014961};
RN [1] {ECO:0000313|EMBL:EPR29363.1, ECO:0000313|Proteomes:UP000014961}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WSUCF1 {ECO:0000313|EMBL:EPR29363.1,
RC ECO:0000313|Proteomes:UP000014961};
RX PubMed=23950119;
RA Bhalla A., Kainth A.S., Sani R.K.;
RT "Draft Genome Sequence of Lignocellulose-Degrading Thermophilic Bacterium
RT Geobacillus sp. Strain WSUCF1.";
RL Genome Announc. 1:e00595-13(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + thymidine = ADP + dTMP + H(+); Xref=Rhea:RHEA:19129,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17748, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:63528, ChEBI:CHEBI:456216; EC=2.7.1.21;
CC Evidence={ECO:0000256|RuleBase:RU000544};
CC -!- SIMILARITY: Belongs to the thymidine kinase family.
CC {ECO:0000256|ARBA:ARBA00007587, ECO:0000256|RuleBase:RU004165}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPR29363.1}.
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DR EMBL; ATCO01000040; EPR29363.1; -; Genomic_DNA.
DR AlphaFoldDB; S7UAU2; -.
DR Proteomes; UP000014961; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004797; F:thymidine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001267; Thymidine_kinase.
DR PANTHER; PTHR11441; THYMIDINE KINASE; 1.
DR PANTHER; PTHR11441:SF0; THYMIDINE KINASE, CYTOSOLIC; 1.
DR Pfam; PF00265; TK; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU000544};
KW DNA synthesis {ECO:0000256|ARBA:ARBA00022634,
KW ECO:0000256|RuleBase:RU000544};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU000544};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU000544};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000544}.
FT NON_TER 72
FT /evidence="ECO:0000313|EMBL:EPR29363.1"
SQ SEQUENCE 72 AA; 8061 MW; 8E2313590D374D4C CRC64;
MYVMTQSGWL EVICGCMFSG KSEELIRRVR RAQFAKQEVK VFKPTIDNRY SEDAVVSHNG
NSVIAIPVAT PA
//
