ID   S7WVD1_9BACT            Unreviewed;       294 AA.
AC   S7WVD1;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=beta-lactamase {ECO:0000256|ARBA:ARBA00012865};
DE            EC=3.5.2.6 {ECO:0000256|ARBA:ARBA00012865};
GN   ORFNames=ADICYQ_3110 {ECO:0000313|EMBL:EPR68038.1};
OS   Cyclobacterium qasimii M12-11B.
OC   Bacteria; Bacteroidota; Cytophagia; Cytophagales; Cyclobacteriaceae;
OC   Cyclobacterium.
OX   NCBI_TaxID=641524 {ECO:0000313|EMBL:EPR68038.1, ECO:0000313|Proteomes:UP000014974};
RN   [1] {ECO:0000313|EMBL:EPR68038.1, ECO:0000313|Proteomes:UP000014974}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M12-11B {ECO:0000313|EMBL:EPR68038.1,
RC   ECO:0000313|Proteomes:UP000014974};
RX   PubMed=23950138;
RA   Shivaji S., Ara S., Singh A., Kumar Pinnaka A.;
RT   "Draft Genome Sequence of Cyclobacterium qasimii Strain M12-11BT, Isolated
RT   from Arctic Marine Sediment.";
RL   Genome Announc. 1:e00642-13(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a beta-lactam + H2O = a substituted beta-amino acid;
CC         Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627,
CC         ChEBI:CHEBI:140347; EC=3.5.2.6;
CC         Evidence={ECO:0000256|ARBA:ARBA00001526};
CC   -!- SIMILARITY: Belongs to the class-A beta-lactamase family.
CC       {ECO:0000256|ARBA:ARBA00009009}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EPR68038.1}.
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DR   EMBL; ATNM01000110; EPR68038.1; -; Genomic_DNA.
DR   RefSeq; WP_020888971.1; NZ_ATNM01000110.1.
DR   AlphaFoldDB; S7WVD1; -.
DR   STRING; 641524.ADICYQ_3110; -.
DR   PATRIC; fig|641524.5.peg.3081; -.
DR   eggNOG; COG2367; Bacteria.
DR   OrthoDB; 9772863at2; -.
DR   Proteomes; UP000014974; Unassembled WGS sequence.
DR   GO; GO:0008800; F:beta-lactamase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030655; P:beta-lactam antibiotic catabolic process; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR045155; Beta-lactam_cat.
DR   InterPro; IPR000871; Beta-lactam_class-A.
DR   PANTHER; PTHR35333; BETA-LACTAMASE; 1.
DR   PANTHER; PTHR35333:SF3; BETA-LACTAMASE2 DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF13354; Beta-lactamase2; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW   Hydrolase {ECO:0000313|EMBL:EPR68038.1}.
FT   DOMAIN          51..266
FT                   /note="Beta-lactamase class A catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF13354"
SQ   SEQUENCE   294 AA;  32454 MW;  CD4D86165A771048 CRC64;
     MNLYLLLPLF LLLSCAGSKE KQDLNQLENG IRDLMQGVEG DFGLAFRLLD DSGKELFINE
     KEVFHAASTM KTPVMIELFK QSAAGKFSLQ DSILIRNEFK SILDGSAYSM DLGVDSQEAL
     YSRIGEKGSR YELMYQMIIK SSNLATNILI EEVGAENVTQ TMRDLGALDI QVLRGVEDLK
     AFEAGLSNTT TALDMMLIME AIAKGKVVGS GNMMEILSDQ HFNGLIPKYL PKTAKIAHKT
     GSITGVQHDA AIVDLVNGKR YVLVILSKNL KDEEVGKESI AKISQLIYTY VVEQ
//