ID S7XJ48_SPRLO Unreviewed; 762 AA.
AC S7XJ48;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE RecName: Full=Eukaryotic translation initiation factor 5B {ECO:0000256|ARBA:ARBA00013824};
DE AltName: Full=Translation initiation factor IF-2 {ECO:0000256|ARBA:ARBA00032478};
GN ORFNames=SLOPH_1985 {ECO:0000313|EMBL:EPR79054.1};
OS Spraguea lophii (strain 42_110) (Microsporidian parasite).
OC Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Spraguidae;
OC Spraguea.
OX NCBI_TaxID=1358809 {ECO:0000313|EMBL:EPR79054.1, ECO:0000313|Proteomes:UP000014978};
RN [1] {ECO:0000313|Proteomes:UP000014978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=42_110 {ECO:0000313|Proteomes:UP000014978};
RX PubMed=23990793; DOI=10.1371/journal.pgen.1003676;
RA Campbell S.E., Williams T.A., Yousuf A., Soanes D.M., Paszkiewicz K.H.,
RA Williams B.A.P.;
RT "The genome of Spraguea lophii and the basis of host-microsporidian
RT interactions.";
RL PLoS Genet. 9:E1003676-E1003676(2013).
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC {ECO:0000256|ARBA:ARBA00007733}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPR79054.1}.
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DR EMBL; ATCN01000420; EPR79054.1; -; Genomic_DNA.
DR AlphaFoldDB; S7XJ48; -.
DR STRING; 1358809.S7XJ48; -.
DR VEuPathDB; MicrosporidiaDB:SLOPH_1985; -.
DR HOGENOM; CLU_002656_3_3_1; -.
DR InParanoid; S7XJ48; -.
DR OrthoDB; 169393at2759; -.
DR Proteomes; UP000014978; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR CDD; cd03703; aeIF5B_II; 1.
DR CDD; cd01887; IF2_eIF5B; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR Gene3D; 3.40.50.10050; Translation initiation factor IF- 2, domain 3; 1.
DR InterPro; IPR029459; EFTU-type.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR015760; TIF_IF2.
DR InterPro; IPR023115; TIF_IF2_dom3.
DR InterPro; IPR036925; TIF_IF2_dom3_sf.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43381:SF4; EUKARYOTIC TRANSLATION INITIATION FACTOR 5B; 1.
DR PANTHER; PTHR43381; TRANSLATION INITIATION FACTOR IF-2-RELATED; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF14578; GTP_EFTU_D4; 1.
DR Pfam; PF11987; IF-2; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF52156; Initiation factor IF2/eIF5b, domain 3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000313|EMBL:EPR79054.1};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000014978}.
FT DOMAIN 179..391
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 1..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..81
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 762 AA; 86448 MW; 141C772E3C8686E1 CRC64;
MDEKNGAGQT TDTKSQKKPK FVRKKKQKGN KQQDVVQKKD VISVPTEKEV VIENKEESTN
EIKKEEKKEK ETEKIEPVKQ GGRRRGPNIA MIKKLAEQKQ KQEEELKKLK KQQEEEDLER
IRKIEEEKKL AIEKQKKEKE ERELENKMKK MKLRNFLVRE KVKTVKKIEK IEEEIETDLK
SPICCILGHV DTGKTKLLDK LRETDVQGSE AGGITQQIGA TFFPVKELKR KFNVPENNLP
GILIIDTPGH ETFSNLRSRG SSLCDIAILV VDILHLLENQ TLESIELLKR RKTPFIIALN
KIDRIYGWKS TNFAGFTESF EKQTDVTKEE FKRQMNDTIV KFSEIGLNTT LFSENNNEKQ
FVSIVPTSAI TGEGIPDLIS TILKLSESFM STKMKYKDEV QCTILEVKEI DGYGSTIDVI
LSNGILRKGD KIAVCGFDGP IITNIKSLLV PKALKEIRVK GEYMQKSEVK ASLGVKIAAL
NLENAVAGSR IVIVKNNEEE AKKEVMQDLQ NVISKVKTEE IGVHLQSSTL GSLEALVEFV
TSSNIPIATV GVGKLNKKDI VRASIMAEKS IEYSPLLCFD IKIDKEISEI AEKYNIKIFC
EKIVYNLLDK YKEYSANLRN KMKDAAKSST IFPCELEILP NCVFNKRSPL VLGVEVKRGI
LKIGTVLCII RKNVLGLGTV TSIENNKKAT EKAVVGDKVA IKIEIGSNET PRLFGRHFVQ
EDLLYSWINR KSIDSLKKNF KEELCDDDWM LVIELKNKLD II
//