ID S8CIB2_9LAMI Unreviewed; 724 AA.
AC S8CIB2;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=long-chain-alcohol oxidase {ECO:0000256|ARBA:ARBA00013125};
DE EC=1.1.3.20 {ECO:0000256|ARBA:ARBA00013125};
DE Flags: Fragment;
GN ORFNames=M569_07992 {ECO:0000313|EMBL:EPS66779.1};
OS Genlisea aurea.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Lamiales; Lentibulariaceae; Genlisea.
OX NCBI_TaxID=192259 {ECO:0000313|EMBL:EPS66779.1, ECO:0000313|Proteomes:UP000015453};
RN [1] {ECO:0000313|EMBL:EPS66779.1, ECO:0000313|Proteomes:UP000015453}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23855885;
RA Leushkin E.V., Sutormin R.A., Nabieva E.R., Penin A.A., Kondrashov A.S.,
RA Logacheva M.D.;
RT "The miniature genome of a carnivorous plant Genlisea aurea contains a low
RT number of genes and short non-coding sequences.";
RL BMC Genomics 14:476-476(2013).
CC -!- FUNCTION: Long-chain fatty alcohol oxidase involved in the omega-
CC oxidation pathway of lipid degradation.
CC {ECO:0000256|ARBA:ARBA00003842}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a long-chain primary fatty alcohol + O2 = a long-chain fatty
CC aldehyde + H2O2; Xref=Rhea:RHEA:22756, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:16240, ChEBI:CHEBI:17176, ChEBI:CHEBI:77396; EC=1.1.3.20;
CC Evidence={ECO:0000256|ARBA:ARBA00000920};
CC -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00010790}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPS66779.1}.
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DR EMBL; AUSU01003483; EPS66779.1; -; Genomic_DNA.
DR AlphaFoldDB; S8CIB2; -.
DR OrthoDB; 601859at2759; -.
DR Proteomes; UP000015453; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0046577; F:long-chain-alcohol oxidase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR InterPro; IPR012400; Long_Oxdase.
DR PANTHER; PTHR46056; LONG-CHAIN-ALCOHOL OXIDASE; 1.
DR PANTHER; PTHR46056:SF12; LONG-CHAIN-ALCOHOL OXIDASE FAO4B; 1.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR Pfam; PF13450; NAD_binding_8; 1.
DR PIRSF; PIRSF028937; Lg_Ch_AO; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|PIRSR:PIRSR028937-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR028937-2};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000015453};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 268..485
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00732"
FT DOMAIN 580..712
FT /note="Glucose-methanol-choline oxidoreductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05199"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 659
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR028937-1"
FT BINDING 220..235
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR028937-2"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EPS66779.1"
FT NON_TER 724
FT /evidence="ECO:0000313|EMBL:EPS66779.1"
SQ SEQUENCE 724 AA; 79351 MW; 09EBF05328E35737 CRC64;
HTLLKGKKKQ PRRRSSHGFS SSQIQSLAAI CQTLIPPLAD HGNKAAPHSS FFDSPSGSEE
VAELLVKRGV PQAVFVVGLV LWVLSTRLGT LLLCGFTCLD WRSPPFLPTF SELQLSKREA
VLQRWSRQGG TFLPLRITFL LVKIMSFFTF FSRTDENSQN PAWESIGYHI ETPVVVERPL
QRRPLQNGII ETITESSLRQ KGLRVITEED DDDDYLNVDC DVVVVGSGCG GSVAAAILAK
SGHKVVVLEK GHYFAAQDYS GLEGPSLSEL YESGAVLSTL GGELMIMAGS TVGGGSAINW
SACIRTPDHI LDEWSKTHNL PLYRTREYQS AMDAVCERIG VTDACDEEGF QNQVLRRGCE
SLGLKVDSVP RNSPSDHYCG SCGYGCRRGA KRGADSTWLV DAVDNSAVIM TGCKAERFIL
AKDENEKTRK RCIGVIATAE NIEKKLKINA RVTISACGSL STPPLLISSG LKNKNIGRNL
HLHPVSFIWG YFPETDTRLK GTSYEGGIIT SIHKVQSEER KPAVQAIVEA ASLGPGAFSS
LFPWTSRNNM DDRMRKYSRT AVLFTLVRDE GSGEVKKLKQ IQYKLSEVDK ENLKTGMRRA
LRILIAAGAT EAGTFRSDGQ RIWCKGTNDD AVEEFLDTVV AADGPRTKSM FWNIYGSAHQ
MGSCRMGRNE DEGAVDERGE SWEAKGLFVC DGSLLPTAVG VNPMVSILAT AYCVANRIAE
SMKQ
//
