ID S8FAE4_9BACT Unreviewed; 616 AA.
AC S8FAE4;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Penicillin-binding protein 2 {ECO:0000313|EMBL:EPT32901.1};
GN Name=mrdA {ECO:0000313|EMBL:EPT32901.1};
GN ORFNames=HMPREF9012_1940 {ECO:0000313|EMBL:EPT32901.1};
OS Bacteroidetes bacterium oral taxon 272 str. F0290.
OC Bacteria; Bacteroidota.
OX NCBI_TaxID=888054 {ECO:0000313|EMBL:EPT32901.1, ECO:0000313|Proteomes:UP000015345};
RN [1] {ECO:0000313|EMBL:EPT32901.1, ECO:0000313|Proteomes:UP000015345}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0290 {ECO:0000313|EMBL:EPT32901.1,
RC ECO:0000313|Proteomes:UP000015345};
RA Durkin A.S., Haft D.R., McCorrison J., Torralba M., Gillis M., Haft D.H.,
RA Methe B., Sutton G., Nelson K.E.;
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPT32901.1}.
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DR EMBL; AUTU01000030; EPT32901.1; -; Genomic_DNA.
DR AlphaFoldDB; S8FAE4; -.
DR PATRIC; fig|888054.3.peg.1989; -.
DR OrthoDB; 9766847at2; -.
DR Proteomes; UP000015345; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:InterPro.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR InterPro; IPR017790; Penicillin-binding_protein_2.
DR NCBIfam; TIGR03423; pbp2_mrdA; 1.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000015345};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 53..222
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 261..585
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 616 AA; 69450 MW; 7546BA678FEDC89E CRC64;
MKKDFDLEKR KYILGGAMIM IVLLYLIRLF DLQIMSSDYK KNADSNAFLH ETLYPSRGVI
YDRNDRLLVY NQPAYDVTVI MKEVTHLDTV DFCQTLKITP DYFKRRLLDI KDRHLNPGYT
PYTHQVLMTQ LSAEECAVFQ EKLFEFPGFY IQRRTIRQYN YNAAAHVLGD IGEVSKTDME
ADDYYVQGDL IGKIGVERSY EEQLRGEKGV EILLRDARGR IQGRYMNGAY DVTPQPGKNL
RLSLDIDLQM LGERLLEGKI GSIVALEPKT GEILCMVSSP SYDPRLMVGR PRGRNHLMLS
KDPWKPLLNR SIMGTYPPGS TFKPSQALVF LQEGIIAPET SYPCYHGFVY AGLRVGCHSH
FSPLPLIPAI ATSCNGYFCW GLYHMMGARK KYGSVQNAMT TWRDYMVSMG YGYPLGVDLP
GEKRGMIPNA QYYDKNYKSA WNGLTVISIS IGQGEVSATP LQIANLSATI ANRGYFITPH
IVRKIEGESI DPLYTTRRYT KVEKQYYEVV AEGMRQAVLG GTCRGANLPG IEVCGKTGTA
QNRGKDHSAF MGFAPMNDPQ IAVAVYVENG GFGAQYGVPI GALIMEQYLN GKLSLASEEM
ADEFQHKRID YGIHER
//
