ID S9Q5M4_9RHOB Unreviewed; 366 AA.
AC S9Q5M4;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=2-dehydropantoate 2-reductase {ECO:0000256|ARBA:ARBA00019465};
GN ORFNames=Salmuc_00483 {ECO:0000313|EMBL:EPX76651.1};
OS Salipiger mucosus DSM 16094.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Salipiger.
OX NCBI_TaxID=1123237 {ECO:0000313|EMBL:EPX76651.1, ECO:0000313|Proteomes:UP000015347};
RN [1] {ECO:0000313|Proteomes:UP000015347}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 16094 {ECO:0000313|Proteomes:UP000015347};
RX PubMed=25197501; DOI=10.4056/sigs.4909790;
RA Riedel T., Spring S., Fiebig A., Petersen J., Kyrpides N.C., Goker M.,
RA Klenk H.P.;
RT "Genome sequence of the exopolysaccharide-producing Salipiger mucosus type
RT strain (DSM 16094(T)), a moderately halophilic member of the Roseobacter
RT clade.";
RL Stand. Genomic Sci. 9:1331-1343(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH;
CC Xref=Rhea:RHEA:16233, ChEBI:CHEBI:11561, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:15980, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349;
CC EC=1.1.1.169; Evidence={ECO:0000256|ARBA:ARBA00000784};
CC -!- PATHWAY: Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-
CC pantoate from 3-methyl-2-oxobutanoate: step 2/2.
CC {ECO:0000256|ARBA:ARBA00004994}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPX76651.1}.
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DR EMBL; APVH01000046; EPX76651.1; -; Genomic_DNA.
DR RefSeq; WP_020039365.1; NZ_KE557282.1.
DR AlphaFoldDB; S9Q5M4; -.
DR STRING; 1123237.Salmuc_00483; -.
DR eggNOG; COG0240; Bacteria.
DR HOGENOM; CLU_056511_2_0_5; -.
DR OrthoDB; 6135265at2; -.
DR UniPathway; UPA00028; UER00004.
DR Proteomes; UP000015347; Unassembled WGS sequence.
DR GO; GO:0008677; F:2-dehydropantoate 2-reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0015940; P:pantothenate biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR013332; KPR_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003421; Opine_DH.
DR PANTHER; PTHR38015; BLR6086 PROTEIN; 1.
DR PANTHER; PTHR38015:SF1; OCTOPINE_DH DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF02558; ApbA; 1.
DR Pfam; PF02317; Octopine_DH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000313|EMBL:EPX76651.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000015347}.
FT DOMAIN 5..102
FT /note="Ketopantoate reductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02558"
FT DOMAIN 182..324
FT /note="Opine dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF02317"
SQ SEQUENCE 366 AA; 38760 MW; 7FA50350CB7BE52A CRC64;
MSCKVGIAGA GSIAFGSAAL LHQNGHDPML WSPSGASTRV LADAPLTATG AIEAEFSPRV
ATSAQQLAEE NDAILIALPA YGHKAVFDAL APHIRDGQHI IVSSHASLGA LYLMQLLEAR
GVQAPITAWG TTAVTGRRGE GATVKVNTVR KKVDLCTVPE PRSDCALAVC TRLFGDVFVP
REGLLAISLS NLNPQNHLGI ALGNITRMER GETWSQGQNV TPKVGALLEA LDAERLAIAE
SLSLQTKTIF EHFSLSFHVP EASVSEMNQQ MHAQGNGGTG PATADSRYVT EDVPYGLQLT
AVLGRLTGHR AELHEAGISI FSAMYGRDFA AENELLNALE LDGFSLDDLR QAARTGLLRK
TPEPAS
//