ID S9RD40_9RHOB Unreviewed; 290 AA.
AC S9RD40;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE SubName: Full=2-hydroxy-3-oxopropionate reductase {ECO:0000313|EMBL:EPX76040.1};
DE EC=1.1.1.60 {ECO:0000313|EMBL:EPX76040.1};
GN ORFNames=Salmuc_00693 {ECO:0000313|EMBL:EPX76040.1};
OS Salipiger mucosus DSM 16094.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Salipiger.
OX NCBI_TaxID=1123237 {ECO:0000313|EMBL:EPX76040.1, ECO:0000313|Proteomes:UP000015347};
RN [1] {ECO:0000313|Proteomes:UP000015347}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 16094 {ECO:0000313|Proteomes:UP000015347};
RX PubMed=25197501; DOI=10.4056/sigs.4909790;
RA Riedel T., Spring S., Fiebig A., Petersen J., Kyrpides N.C., Goker M.,
RA Klenk H.P.;
RT "Genome sequence of the exopolysaccharide-producing Salipiger mucosus type
RT strain (DSM 16094(T)), a moderately halophilic member of the Roseobacter
RT clade.";
RL Stand. Genomic Sci. 9:1331-1343(2014).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPX76040.1}.
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DR EMBL; APVH01000061; EPX76040.1; -; Genomic_DNA.
DR RefSeq; WP_020039987.1; NZ_KE557285.1.
DR AlphaFoldDB; S9RD40; -.
DR STRING; 1123237.Salmuc_00693; -.
DR eggNOG; COG2084; Bacteria.
DR HOGENOM; CLU_035117_1_0_5; -.
DR OrthoDB; 9812907at2; -.
DR Proteomes; UP000015347; Unassembled WGS sequence.
DR GO; GO:0008679; F:2-hydroxy-3-oxopropionate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR43060:SF15; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000313|EMBL:EPX76040.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000015347}.
FT DOMAIN 4..160
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 166..285
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 172
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 290 AA; 30348 MW; A458017F5223C603 CRC64;
MAKCAFLGLG VMGYPMAGYL AKAGHEVTVY NRTAAKAEKW VSEYGGASAA TPREAAEGAE
FVMACVGNDD DLREVCTGTD GAFSGMSQGA IFVDHTTVSS MVTEELAAVA HDQGCGFVDA
PVSGGQAGAE NGQLVVMCGG EQAHYDAAAP LIDCYAKLCK RLGGPGAGQL CKMVNQICIA
GLVQGLSEGL AFAEKAGIDG RDVVEVIGGG AAGSWQMVNR YETMLDDKFD HGFAVDWMRK
DLKICLATAD EVGASLPVTA LVDQFYKDVQ KMGGGRWDTS SLIKRLKAFD
//
