ID S9TSF3_9TRYP Unreviewed; 1033 AA.
AC S9TSF3;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 22-FEB-2023, entry version 33.
DE SubName: Full=Other hect domain ubiquitin protein ligase E3 {ECO:0000313|EMBL:EPY19494.1};
GN ORFNames=STCU_09426 {ECO:0000313|EMBL:EPY19494.1};
OS Strigomonas culicis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Strigomonadinae; Strigomonas.
OX NCBI_TaxID=28005 {ECO:0000313|EMBL:EPY19494.1, ECO:0000313|Proteomes:UP000015354};
RN [1] {ECO:0000313|EMBL:EPY19494.1, ECO:0000313|Proteomes:UP000015354}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23560078;
RA Motta M.C., Martins A.C., de Souza S.S., Catta-Preta C.M., Silva R.,
RA Klein C.C., de Almeida L.G., de Lima Cunha O., Ciapina L.P., Brocchi M.,
RA Colabardini A.C., de Araujo Lima B., Machado C.R., de Almeida Soares C.M.,
RA Probst C.M., de Menezes C.B., Thompson C.E., Bartholomeu D.C., Gradia D.F.,
RA Pavoni D.P., Grisard E.C., Fantinatti-Garboggini F., Marchini F.K.,
RA Rodrigues-Luiz G.F., Wagner G., Goldman G.H., Fietto J.L., Elias M.C.,
RA Goldman M.H., Sagot M.F., Pereira M., Stoco P.H., de Mendonca-Neto R.P.,
RA Teixeira S.M., Maciel T.E., de Oliveira Mendes T.A., Urmenyi T.P.,
RA de Souza W., Schenkman S., de Vasconcelos A.T.;
RT "Predicting the Proteins of Angomonas deanei, Strigomonas culicis and Their
RT Respective Endosymbionts Reveals New Aspects of the Trypanosomatidae
RT Family.";
RL PLoS ONE 8:E60209-E60209(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPY19494.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ATMH01009426; EPY19494.1; -; Genomic_DNA.
DR AlphaFoldDB; S9TSF3; -.
DR EnsemblProtists; EPY19494; EPY19494; STCU_09426.
DR OrthoDB; 1093891at2759; -.
DR Proteomes; UP000015354; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR045322; HECTD1/TRIP12-like.
DR PANTHER; PTHR45670; E3 UBIQUITIN-PROTEIN LIGASE TRIP12; 1.
DR PANTHER; PTHR45670:SF15; LIGASE, PUTATIVE-RELATED; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW Ligase {ECO:0000313|EMBL:EPY19494.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000015354};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 874..1033
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 269..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 278..296
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1000
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 1033 AA; 113091 MW; 5C955B6204190D17 CRC64;
MDGVLAVIVS LLAKNEHLLL HFPNPFTHKV VSSGAEEPAA ATEGDEAVRV LSNLQWEVSN
AQWSALALLG KLLGAVPVAR GRYEWAFRDT DDMYYCYGAK DAVTLTNAYF ARVPTVELMD
ENDAHDVNLH LMTDTNSRSK IKSQMFFQPV PTQYVLESRL PHVPSAALAE QQVRACPVKA
ELRRALRAMS FGSTPVAALA KMVFLHLVCH DTPQNTEETK AALRNLVATQ SAAVLEHLST
TLVKRDATWA VILHEAGIGE AMQGLWPHAP LESLPRTAGT RKRGRGDERG EPPGRHRPSP
IVESLSRAAG SAPPTPALLP QTTADVELFL KTASFAELFR LLEDLDTVDR GTCEKVVHTA
CALPAGSEAH RTWCTALVAY LLRELQKLSI HGSTLHLLDT VQSDRSVRAV FVCRDAEAAA
SGGAAPSLLF CKNKHPLRVH FSTNWKCDLC GGSSEYGSLA CRTCNYDVCS HCTERALGCV
RANVSATVGD VLESWRENND PNANKKKKKR SHAPSVEGLD LFTRAALFAH TTPVCAVLQQ
QQPLHCAAIG GACACRVTRP HAAGGWAQQP KDSPIFRLLR HFAAFLCEDN AVWRGLIEAV
TSYGALVFTH GVLGLPEPLY SVIDCLRRSL PLAFKCELTR FLAVDCRRYA LQFIADAGVT
LRGTAQGALH SNGLAGKITV PRDNERGALL RLADAFHPSL TLRSKLTFAF EGEEGTGNGP
TQELYAEMSS FFTGCKPMWY VTDDQRTIGL PSRTENRETE FFVCGALTGR AFVDGYTMDV
SYHPLVWTLL RCSDRDGATV SKEQLLHTSS LWALLSELEP TMANSFKQML LASASELELM
GLEDENEQSI KPENVLDFVV GRIKAHFSTT LMNLQAFLLG LLRSVDLSTL FSLSDEELCV
VLGGQDSEEE GAAPLFTEAQ LESVVTEAHG YTAGSKEVKL FTSIVGGDFG RKEQRLFLEF
LTGSSRLPLN GLQGLGRKIT VVKKEMDSKN EATLPSCSTC FLYLKLPPYT SRDIMKQRLL
LAVTEGRKNF SLS
//
