ID S9UK10_9TRYP Unreviewed; 684 AA.
AC S9UK10;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 08-NOV-2023, entry version 29.
DE SubName: Full=Calpain-like cysteine peptidase {ECO:0000313|EMBL:EPY29273.1};
GN ORFNames=STCU_04638 {ECO:0000313|EMBL:EPY29273.1};
OS Strigomonas culicis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Strigomonadinae; Strigomonas.
OX NCBI_TaxID=28005 {ECO:0000313|EMBL:EPY29273.1, ECO:0000313|Proteomes:UP000015354};
RN [1] {ECO:0000313|EMBL:EPY29273.1, ECO:0000313|Proteomes:UP000015354}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23560078;
RA Motta M.C., Martins A.C., de Souza S.S., Catta-Preta C.M., Silva R.,
RA Klein C.C., de Almeida L.G., de Lima Cunha O., Ciapina L.P., Brocchi M.,
RA Colabardini A.C., de Araujo Lima B., Machado C.R., de Almeida Soares C.M.,
RA Probst C.M., de Menezes C.B., Thompson C.E., Bartholomeu D.C., Gradia D.F.,
RA Pavoni D.P., Grisard E.C., Fantinatti-Garboggini F., Marchini F.K.,
RA Rodrigues-Luiz G.F., Wagner G., Goldman G.H., Fietto J.L., Elias M.C.,
RA Goldman M.H., Sagot M.F., Pereira M., Stoco P.H., de Mendonca-Neto R.P.,
RA Teixeira S.M., Maciel T.E., de Oliveira Mendes T.A., Urmenyi T.P.,
RA de Souza W., Schenkman S., de Vasconcelos A.T.;
RT "Predicting the Proteins of Angomonas deanei, Strigomonas culicis and Their
RT Respective Endosymbionts Reveals New Aspects of the Trypanosomatidae
RT Family.";
RL PLoS ONE 8:E60209-E60209(2013).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00239}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPY29273.1}.
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DR EMBL; ATMH01004638; EPY29273.1; -; Genomic_DNA.
DR AlphaFoldDB; S9UK10; -.
DR EnsemblProtists; EPY29273; EPY29273; STCU_04638.
DR OrthoDB; 142935at2759; -.
DR Proteomes; UP000015354; Unassembled WGS sequence.
DR GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd00044; CysPc; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR InterPro; IPR022684; Calpain_cysteine_protease.
DR InterPro; IPR015232; DUF1935.
DR InterPro; IPR013780; Glyco_hydro_b.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR InterPro; IPR036310; Smp-1-like_sf.
DR PANTHER; PTHR47047:SF1; CYSTEINE PEPTIDASE, PUTATIVE CYSTEINE PEPTIDASE, CLAN CA, FAMILY C2, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR47047; PUTATIVE-RELATED-RELATED; 1.
DR Pfam; PF09149; DUF1935; 1.
DR Pfam; PF00648; Peptidase_C2; 1.
DR PRINTS; PR00704; CALPAIN.
DR SMART; SM00230; CysPc; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF101601; Smp-1-like; 1.
DR PROSITE; PS50203; CALPAIN_CAT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000015354}.
FT DOMAIN 170..495
FT /note="Calpain catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50203"
FT ACT_SITE 413
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1"
FT ACT_SITE 435
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1"
SQ SEQUENCE 684 AA; 77312 MW; F71D709ABC5120A8 CRC64;
MNKGKIDEFD EGTVVLESKS TYKNGEPVYK GETTPCFDEG LLFRVVETSN NNRWSFYNDT
VNCQMRVQFV FGKESKLKVL ENAQMEELQS GSYRVTVTVY PMETELFVEG EANGYTSNIR
AQPLSEDYLR DMAKQDNQFV KLETAALYNV VGDNAPTDAM VKACVQTGLK FVDFAFPPDQ
KSLQIGSLLK MKVLPWERPC MFLSDANAEQ VRLFRNGVHP ANIDEGDLGD SWLTGAMACL
AEFPDKIRDL FRHPENVEEG KKERANGIYR VTFNKNGWWM NVIVDDYLPV AGGRPKFGRS
KGDPAELWVA ILQKAYAKVF GGYGFIIAGD PLHALQDLSG FPCSSFDNAF VESTINETYE
LFEHLLQYTS TGYQLVFTTP TREAIMSARG AAACGSPAAA EVSFTKANLL LGHTYAVLKV
GYFPQTNLRL LQFRNPWSTS KSDWNGPWNK RDPNWKKFAE IANYFNFDEE DDGTFYMEWP
DVQDYFVGCG VCFLQHPVYD YRCRGTFFQN VPTTCLEISV RRPIILNLML SQEDKRGTDK
AENSPIMISV AHGCGQVSPM RVDLNSGFDN DHPTPEFTFL QSRDVSMFYE FLPQFSPYLV
VPRAMSTYPS LPYTMGLLSP AEIGTDASDV RVAFRALAPE NRVFDNYQNF NCETVATETE
FQAKSPNQFF PDIYVGTILQ TSNQ
//
