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Database: UniProt
Entry: S9V805_9TRYP
LinkDB: S9V805_9TRYP
Original site: S9V805_9TRYP 
ID   S9V805_9TRYP            Unreviewed;       780 AA.
AC   S9V805;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   15-FEB-2017, entry version 11.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=STCU_09631 {ECO:0000313|EMBL:EPY19085.1};
OS   Strigomonas culicis.
OC   Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae;
OC   Strigomonadinae; Strigomonas.
OX   NCBI_TaxID=28005 {ECO:0000313|EMBL:EPY19085.1, ECO:0000313|Proteomes:UP000015354};
RN   [1] {ECO:0000313|EMBL:EPY19085.1, ECO:0000313|Proteomes:UP000015354}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23560078;
RA   Motta M.C., Martins A.C., de Souza S.S., Catta-Preta C.M., Silva R.,
RA   Klein C.C., de Almeida L.G., de Lima Cunha O., Ciapina L.P.,
RA   Brocchi M., Colabardini A.C., de Araujo Lima B., Machado C.R.,
RA   de Almeida Soares C.M., Probst C.M., de Menezes C.B., Thompson C.E.,
RA   Bartholomeu D.C., Gradia D.F., Pavoni D.P., Grisard E.C.,
RA   Fantinatti-Garboggini F., Marchini F.K., Rodrigues-Luiz G.F.,
RA   Wagner G., Goldman G.H., Fietto J.L., Elias M.C., Goldman M.H.,
RA   Sagot M.F., Pereira M., Stoco P.H., de Mendonca-Neto R.P.,
RA   Teixeira S.M., Maciel T.E., de Oliveira Mendes T.A., Urmenyi T.P.,
RA   de Souza W., Schenkman S., de Vasconcelos A.T.;
RT   "Predicting the Proteins of Angomonas deanei, Strigomonas culicis and
RT   Their Respective Endosymbionts Reveals New Aspects of the
RT   Trypanosomatidae Family.";
RL   PLoS ONE 8:E60209-E60209(2013).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EPY19085.1}.
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DR   EMBL; ATMH01009631; EPY19085.1; -; Genomic_DNA.
DR   EnsemblProtists; EPY19085; EPY19085; STCU_09631.
DR   Proteomes; UP000015354; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 2.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000015354};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000015354};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    474    498       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    519    536       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    604    625       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    637    661       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    699    723       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   780 AA;  88924 MW;  95E0BF5CF6A33683 CRC64;
     MSWTTERCSG LWRSEDMVRL NIIIQREVLH DTIFKIGLMG KVQFLDMDDG AAAFSKPYTN
     EIRRCEDLQR KLRVVEEHIL QEPPTLLEKY NDIEMSASVG ELREATLEGQ LDNIDERVEA
     LLTDLMAMVT SLEGLQNEMN NNQQLITLYR RMQSLMNGEA EGSRLSVTDT RSTSFLSSPV
     LTSFSSLSSF NTVIGLVNTA QADVLYRICY RVTRGNALIL IYNEPDPFVD PKTGERNVAL
     SSFIILSSSQ RMVQRIYKLI GGLKTIIYAL DEVSTRGAAL SEQAEELARR AADHRDSGDG
     LSATHVRVTL TTGGGSTNQD QWSHASVASP VDRVHSNLQS SAQLQQAMDT IRQRKQDLLL
     HWYEEHRLYK TIVRLEKTIL TTMNLCAVSG ATCTASVWIP CRYESMLEQA LHEAVYASGE
     VHSIITRHVH QTRPPTYYET NKFTSSFQSI VDSYGMARYK EVNPGVFTII TFPYLFGIMY
     GDIGHGILLL CISLFFIYKE RSWTGQPLNE IIGMIFGGRY LLLLMSLFAT YMGFLYNDFF
     GFSVNIFKSG YTWPSLETRN KSEHTMYPSN PNGLPSVKPP HVYVFGLDVA WAETENKLEF
     YNSVKMKCAV VVGVTQMFAG VILSLNNHIY NKDWLRIAFL TVPEFLFLLV TFGYMSILII
     VKWCTTWEST HDAPSLLETM TNFFLQPTSL SNPLFAGQMG LQIFFLLVAL LMVPLMLCGM
     PVIEYRKYQR YLARQRKWRF RTWTSCGMTR PSPPSGRRRA RSPWRPAMMR SKRKAPRPSW
//
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