ID S9VFE0_9TRYP Unreviewed; 971 AA.
AC S9VFE0;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Protein kinase {ECO:0000313|EMBL:EPY25771.1};
GN ORFNames=STCU_06485 {ECO:0000313|EMBL:EPY25771.1};
OS Strigomonas culicis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Strigomonadinae; Strigomonas.
OX NCBI_TaxID=28005 {ECO:0000313|EMBL:EPY25771.1, ECO:0000313|Proteomes:UP000015354};
RN [1] {ECO:0000313|EMBL:EPY25771.1, ECO:0000313|Proteomes:UP000015354}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23560078;
RA Motta M.C., Martins A.C., de Souza S.S., Catta-Preta C.M., Silva R.,
RA Klein C.C., de Almeida L.G., de Lima Cunha O., Ciapina L.P., Brocchi M.,
RA Colabardini A.C., de Araujo Lima B., Machado C.R., de Almeida Soares C.M.,
RA Probst C.M., de Menezes C.B., Thompson C.E., Bartholomeu D.C., Gradia D.F.,
RA Pavoni D.P., Grisard E.C., Fantinatti-Garboggini F., Marchini F.K.,
RA Rodrigues-Luiz G.F., Wagner G., Goldman G.H., Fietto J.L., Elias M.C.,
RA Goldman M.H., Sagot M.F., Pereira M., Stoco P.H., de Mendonca-Neto R.P.,
RA Teixeira S.M., Maciel T.E., de Oliveira Mendes T.A., Urmenyi T.P.,
RA de Souza W., Schenkman S., de Vasconcelos A.T.;
RT "Predicting the Proteins of Angomonas deanei, Strigomonas culicis and Their
RT Respective Endosymbionts Reveals New Aspects of the Trypanosomatidae
RT Family.";
RL PLoS ONE 8:E60209-E60209(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EPY25771.1}.
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DR EMBL; ATMH01006485; EPY25771.1; -; Genomic_DNA.
DR AlphaFoldDB; S9VFE0; -.
DR EnsemblProtists; EPY25771; EPY25771; STCU_06485.
DR OrthoDB; 169197at2759; -.
DR Proteomes; UP000015354; Unassembled WGS sequence.
DR GO; GO:0005929; C:cilium; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd14008; STKc_LKB1_CaMKK; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR24346:SF77; CALCIUM_CALMODULIN-DEPENDENT PROTEIN KINASE KINASE 1; 1.
DR PANTHER; PTHR24346; MAP/MICROTUBULE AFFINITY-REGULATING KINASE; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000313|EMBL:EPY25771.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000015354};
KW Transferase {ECO:0000313|EMBL:EPY25771.1}.
FT DOMAIN 186..449
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 846..875
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 846..866
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 215
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 971 AA; 108299 MW; 08E965CCAE51C0F7 CRC64;
MQGNRENLGS LHSFTQPKSM DQGTTGGLAL FCNKPKECRG CGSAAVAYMC EKCEDWFVCE
DCRFDRELMD DHDIRHPIVS LVETHCNSSR TFGGDSYSLM TVDGNTSSLF YDPCSVCGQS
IEDTEVVYRC EQCNLIMCER CYKNPANKHE HELRRFKRRA RSSNVPETTL VNKSRSSDGN
KIINDYVVVK VLGQGSFAKV KLVQHIRTRE LFALKILKRK RKQAQSSGIK RSIKTTNVEM
DEDDLLREIA VMKFIDHPNV VQLKEVIEDV DSLRVYIIME YCERGPVHIL GRPPLPISQV
RKYGSDILRG ILHLHSEFLY HRDIKPANCL VDAYDTVKLA DFGTCNSRAK ADTQQTPAFS
TPEQIRGESV IGSVVDSWSF ALTLYQMAFG RLPYSTTSLY VLRNELMSPD PVNIGEDGDA
QLTDLLRRML CKDLSRRLMV EAAATHPFFG LEMDSQRNVR RVSKEVQISS PSNQELYKKA
AQEVRRGKNL NECFHGVKAI RTLRNKEANY AAEKGVANAL EADEEGWLYD LDSNNNSVLE
LEGVNDRSGV STASITDFVQ QASAGALQPD HTTDRAGPEV LALIRKCVEA KDRKLQLLKL
PMGAPPAELS DVAPYVTEMR LSYNGLQRMS LGTFASFSLL KDITITFNKL AVFPEELLQA
PRLLRLDLST NRIADIPPAV ARARFLQRLN LHNNLITQVG TGADGRSVLA SPCLRHVRLS
SNPLRSIPSA LDTTNSLELV MDTIPALTEA WDALVQRCMP DNPPALVVWD DYFPERIRDC
AYPIWVASSN LALYRVHTLT TCAVQHAVLF QCNDTRFPCG FFPSKDLTTY FIKLAARVSM
AIQQTGSNGS NGAASPTRSM GSRGSGTSLG DPAERARHGV AKALRTLPSV VSRSARNQIQ
SYFFISDNLE DSEGGYKKLC DFIREVLQAR ESIIFFMTPG SEGKDARDIA TGALAEIWNE
QTHGTVDQVH G
//
